Maternal plasma lipid concentration in first and second trimester of pregnancy and risk of preeclampsia

Jašović-Siveska, Emilija; Milkovski, Daniel

doi:10.15406/ogij.2019.10.00458

Cited by 4 publications

(5 citation statements)

References 16 publications

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“…In this review, we found that the mean serum total cholesterol level was significantly higher in preeclamptic women as compared to normotensive pregnant women (221.84 ± 47.61 and 190.43 ± 40.55), respectively and its pooled SMD was (SMD = 0.82, 95% CI: 0.35, 1.29). Similar results were reported in the studies conducted in China and India [ 36 , 37 ]. The plasma cholesterol level increases during pregnancy in response to an increase estrogen induced hepatic synthesis or failure of lipoprotein lipase to clear the plasma lipids.…”

Section: Discussionsupporting

confidence: 91%

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

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Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

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Section: Discussionsupporting

confidence: 91%

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

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“…The FFA/albumin ratio is increased in women with preeclampsia leading to further lipolytic activity, thereby more endothelial FFA uptake and esterification to TG [ 2 ]. The previous study shows an increase in proatherogenic lipids like TG, small dense low-density lipoprotein (LDL), and decreased high-density lipoprotein (HDL); with progression, pregnancy may lead to preeclampsia [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to HTG-induced preeclampsia contributing to the increased number of spontaneous delivery of preterm births. Also increased TG level leads to a greater risk for large-for-gestational-age babies [ 19 ]. In this group, we found that 5.6% of neonates have macrosomia, which is significantly higher compared to high TG level mothers to lower TG level mothers (p < 0.032).…”

Section: Discussionmentioning

confidence: 99%

Complications of Hypertriglyceridemia in Pregnancy and Its Impact on Neonates: a Hospital-Based Study From Odisha

Dash¹,

Tiwari²,

Dash³

et al. 2022

Cureus

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Objective Hypertriglyceridemia (HTG) in pregnancy causes an increased risk for maternal and fetal complications. But, reports on the impact of HTG in pregnancy on maternal and fetal outcomes are scarce in developing countries. We aim to determine the maternal and neonatal complications of HTG in pregnancy. Materials and methods This prospective observational study was conducted on 150 pregnant women with HTG in the department of obstetrics and gynecology, KIMS, Bhubaneswar, from December 2019 to November 2020. Measurement of triglycerides during the first trimester, second trimester, and delivery was done. Maternal complications and neonatal outcomes in HTG mothers and mothers with normal triglyceride levels were compared. Results Out of 150 HTG cases, hypothyroidism, preeclampsia, acute pancreatitis, and sickle cell crisis occurred in 41 (27.3%), 22 (14.7%), six (4%), and three (2%) cases, respectively. The triglyceridemia (TG) levels raised from 133.7±48.2 mg/dl in the first trimester to 232.8±151.0 mg/dl in the third trimester. There is a significant increase in TG levels at the time of delivery compared to the first and second trimesters (p< .001). Out of 140 neonates, 30 (21.4%) were preterm, eight (5.7%) had intrauterine growth restriction (IUGR), and four (6.06%) were macrosomic. Intrauterine death, preterm, and macrosomia are significantly associated with maternal HTG compared to normal mothers (p < .032). All mortalities were due to acute pancreatitis (6; 4%) among mothers and four intrauterine fetal death. Conclusion There is a steady increase in TG levels in the successive trimesters of pregnancy. Gestational severe hypertriglyceridemia causes life-threatening complications. HTG-induced acute pancreatitis needs to be managed aggressively to prevent maternal death. Neonates of HTG mothers suffer from complications like prematurity, IUGR, and macrosomia.

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“…Abnormal pre-pregnancy body weight is associated with higher risk of PE, through changing lipid metabolism pattern and immune dysregulation. This metabolic maladaptation is a typical manifestation of preeclampsia which occurred before the incidence of the clinical symptoms of the disease 9,14 . Lipid induced alterations could play a signi cant role in endothelial dysfunction and disease progression 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of maternal serum lipid profiles and clinical chemistry parameters in the prediction of pre-eclampsia in pregnant women attending ANC and delivery services

Tesfa

Munshea

Nibret

et al. 2023

Preprint

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Pre-eclampsia (PE) is a pregnancy related metabolic syndrome which adversely influence the mother and their newborn infants. Besides, lack of study in our population, some studies also reporting discrepancies in the association of lipid profiles and clinical chemistry parameters with the risk of PE. Hence, this study was designed to evaluate the diagnostic potential of serum lipid profiles and clinical chemistry parameters with PE. Institution-based case-control study was performed at Bahir Dar city governmental hospitals. The study participants were selected through simple random sampling and the socio-demographic data were collected by interview-administered questionnaire. Five ml of venous blood were collected to evaluate lipid profile and clinical chemistry parameters. Descriptive statistics, chi-squared test, multivariable logistic regression and Mann-Whitney U test were utilized for analysis of variables. ROC and combined ROC curve analysis were executed to check the diagnostic accuracy at 95% CI. A total of 336 study participants (168 cases and 168 controls) were included. The median concentrations of serum triglyceride (229 (180-293.75) vs 194 (158.5–255)), total cholesterol (196 (167.25–224) vs 185.5 (158.5-212.75)), ALT (23(20–32) vs 21 (20–25)) and AST (35 (23.25-45) vs 24 (20–35)) values were significantly increased in cases as compared with normal controls. However, the median concentrations of serum total protein (6.7(6.1–7.4) vs 7.1 (6.7–7.6)) and serum calcium (7.6 (7.1–7.9) vs 7.9(7.5–8.3)) were significantly decreased in cases than controls. Positive correlations were observed between blood pressure and serum levels of triglyceride, total cholesterol, ALT & AST values while negative correlations were shown between blood pressure and HDL-cholesterol, total protein and serum calcium values. The combined ROC curve analysis of serum lipid profiles and clinical chemistry parameters showed a moderate prediction potential of PE. Hence, serum lipid profiles and clinical chemistry parameters were utilized as the diagnostic biomarkers of PE. However, to generate tangible evidence on the roles of lipid profiles and clinical chemistry parameters in PE pathogenesis and to include them as routine diagnostic biomarker multi-center prospective studies will be warranted.

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Maternal plasma lipid concentration in first and second trimester of pregnancy and risk of preeclampsia

Cited by 4 publications

References 16 publications

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Complications of Hypertriglyceridemia in Pregnancy and Its Impact on Neonates: a Hospital-Based Study From Odisha

Evaluation of maternal serum lipid profiles and clinical chemistry parameters in the prediction of pre-eclampsia in pregnant women attending ANC and delivery services

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