Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Tesfa, Endalamaw; Nibret, Endalkachew; Munshea, Abaineh

doi:10.1371/journal.pone.0243538

Cited by 24 publications

(22 citation statements)

References 43 publications

(88 reference statements)

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“…Our findings are in agreement with the studies of Makedou et al, [18] and Tesfa et al, [19] who reported that pregnant women presented higher oxidized low-density lipoprotein levels than non-pregnant control hence, predisposing them to preeclampsia and other pregnancy complications. Also, the level of oxidized low-density lipoprotein in the first and third trimester (3716±599.86pg/ml and 4031.98±103.50 respectively) was higher in the pregnant women than in the control.…”

Section: Discussionsupporting

confidence: 94%

Assessment of oxidative and cardiovascular changes in pregnant women attending antenatal clinic at Federal Medical Centre, Owerri Nigeria

Eziechile¹,

Oguji²,

Chukwu³

et al. 2022

Int. J. Sci. Res. Arch.

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Background: In pregnancy which is a physiological state that is accompanied by high energy demand, there is an increased intake and utilization of oxygen, hence augmented levels of oxidative changes that are associated with a lot of risks, one of which is cardiovascular diseases. This research aims to investigate the oxidative changes that occur among pregnant women by determining the levels of High Sensitivity c-Reactive Protein (hs-CRP) and Oxidized Low-Density Lipoprotein (OxLDL) in first, second and third trimesters. Materials and Methodology: A total of 60 pregnant women were recruited for the study. Twenty (20) pregnant women each from the three trimesters while Twenty (20) non-pregnant pubertal women without any chronic disease were used as control. 5ml of venous blood was collected from all subjects and analyzed for OxLDL and hs-CRP using an Enzyme-Linked Immunosorbent Assay (ELISA) technique. The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 18. Results: Oxidized Low-Density Lipoprotein (OxLDL) showed mean variations across the groups but was not significant (P>0.05) but Pregnant women in their second trimester showed significant mean variation (P<0.05) (3716.11±599.86) in when compared to non-pregnant women (control) (4305.33±68.90) respectively. Pregnant women in the second trimester showed significantly decreased mean variation (P<0.05) in High sensitivity C-reactive protein (85.09 ±12.38) when compared to non-pregnant women (control) (219.45 ±64.61) respectively. Conclusions: This study shows that there are increases in levels of OxLDL and a decrease in plasma concentration of hs-CRP which are more significant in the second trimester.

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Section: Discussionsupporting

confidence: 94%

Assessment of oxidative and cardiovascular changes in pregnant women attending antenatal clinic at Federal Medical Centre, Owerri Nigeria

Eziechile¹,

Oguji²,

Chukwu³

et al. 2022

Int. J. Sci. Res. Arch.

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“…Similar lipid profile variations in preeclampsia have been reported in other studies [13,14,24,25,26]. A meta-analysis of studies examining lipids in pregnancy documented "increased levels of total cholesterol, triglycerides, low-density lipoprotein and other non-high-density lipoproteins with a significantly reduced level of high-density lipoprotein in the third trimesters in preeclampsia" [27]. These observations were different from that of Olalare et al, [18] who reported no difference.…”

Section: Discussionsupporting

confidence: 66%

Maternal Lipid Profile in Preeclampsia: Case-Control Study

Agbara

Rabiu

Gbadegesin

et al. 2021

JAMMR

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Background: Preeclampsia has continued to be a challenge especially in the areas of understanding the pathogenesis and prevention or treatment of the disease. Previous reports on the relationship between maternal lipids and preeclampsia have varied as its role in the aetiopathogenesis of pre-eclampsia is not clearly defined. This study aimed at comparing the lipid profile in preeclampsia with that in normotensive pregnancy. It also examined for any relationship between an abnormal profile and severe disease. Methods: This was a prospective case-control study. It was conducted among pregnant women who presented for routine antenatal care and those seen in the emergency room of the obstetrics unit of a tertiary institution in Lagos, Nigeria. The duration of the study was 6 months as it took place between May 2015 to October 2015. Pregnant women in their second half of pregnancy, diagnosed to have pre-eclampsia and, who gave consent were consecutively recruited as cases and pregnant women with similar age and gestational age, who had normal blood pressure were also selected as controls within the study period. The Maternal lipid profile was assayed using an enzyme-based assay kit and analysed according to the manufacturer’s instructions. All participants were followed up till delivery. Results: One hundred and seventy pregnant women in the third trimester of pregnancy participated in this study. They were within 18 – 45 years of age. More of the participants were nulliparous. Eighty-five of them had pre-eclampsia and constituted the study group while 85 were normotensive in the control group. The mean age was similar in both groups (control=29.59 ± 4.50 years versus pre-eclampsia=29.73 ± 5.10 years). The gestational ages at blood sampling of the patients in this study ranged between 27 – 40 weeks. The analysis of data revealed that the level of total cholesterol, triglycerides, low-density lipoprotein and very-low-density lipoprotein was higher in the cases compared with the control. This difference was statistically significant because the calculated P-value was <0.05. The level of high-density lipoprotein was lower in those with pre-eclampsia. Serum cholesterol and low-density lipoprotein were significantly higher (P-value= 0.04) in those with severe disease. A significant positive relationship was observed between mean arterial blood pressure and abnormal levels of lipids. Conclusion: An abnormal pattern of lipid profile was observed in women with preeclampsia and this was more marked in those with severe disease. A larger multi-centre study will be required to substantiate this finding.

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“…Serum fatty acid consists of different fatty acid fractions, including long-chain polyunsaturated fatty acid (LCPUFA), monounsaturated fatty acid (MUFA) and saturated fatty acid (SFA), together with all of their fractions. A lipidomic analysis showed a different role of this fatty acid in the pathogenesis of the disease [ 9 – 12 ]. Omega-3 LCPUFA and omega-6 fraction are precursors of prostanoids and leukotrienes involved in inflammation, vasoconstriction, oxidative stress, and platelet aggregation [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis

Herlambang

Puspasari

Maharani

et al. 2022

BMC Pregnancy Childbirth

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Background Preeclampsia is a complication during pregnancy characterised by new-onset hypertension and proteinuria that develops after 20 weeks of gestation. Dyslipidemia in pregnancy is correlated with an increased risk of preeclampsia. However, the dynamic changes in lipid metabolic product, particularly fatty acid fraction, in preeclampsia maternal circulation, are not well understood. This study aimed to investigate fatty acid fraction in preeclampsia maternal blood compared with normotensive normal pregnancy. Methods A total of 34 women who developed preeclampsia and 32 women with normotensive normal pregnancy were included in our case-control study. Maternal blood samples were collected for serum fatty acid fractions analysis and other biochemical parameters. Serum fatty acid fractions included long-chain polyunsaturated fatty acid (LCPUFA), monounsaturated fatty acid (MUFA), saturated fatty acid, and total fatty acid, measured with gas chromatography-mass spectrometry (GC-MS). The mean difference of fatty acid level was analysed using parametric and non-parametric bivariate analysis based on normality distributed data, while the risk of preeclampsia based on fatty acid fraction was analysed using a logistic regression model. Results Women with preeclampsia have lower high-density lipoprotein (53.97 ± 12.82 mg/dL vs. 63.71 ± 15.20 mg/dL, p = 0.006), higher triglyceride (284.91 ± 97.68 mg/dL vs. 232.84 ± 73.69 mg/dL, p = 0.018) than that in the normotensive group. Higher palmitoleic acid was found in women with preeclampsia compared to normotensive normal pregnancy (422.94 ± 195.99 vs. 325.71 ± 111.03 μmol/L, p = 0.037). The binary logistic regression model showed that pregnant women who had total omega-3 levels within the reference values had a higher risk of suffering preeclampsia than those with the higher reference value (odds ratio OR (95% CI): 8,5 (1.51–48.07), p = 0.015). Pregnant women who have saturated fatty acid within reference values had a lower risk for suffering preeclampsia than those in upper reference value (OR (95% CI): 0.21 (0.52–0.88), p = 0.032). Conclusion Overall, palmitoleic acid was higher in women with preeclampsia. Further analysis indicated that reference omega-3 in and high saturated fatty acid serum levels are characteristics of women with preeclampsia.

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Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Cited by 24 publications

References 43 publications

Assessment of oxidative and cardiovascular changes in pregnant women attending antenatal clinic at Federal Medical Centre, Owerri Nigeria

Assessment of oxidative and cardiovascular changes in pregnant women attending antenatal clinic at Federal Medical Centre, Owerri Nigeria

Maternal Lipid Profile in Preeclampsia: Case-Control Study

Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis

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