Maternal hemoglobin concentration and its association with birth weight in newborns of mothers with preeclampsia

Abstract

OBJECTIVE Maternal hemoglobin concentration is inversely related to newborn size presumably through plasma volume constriction. We sought to determine whether birth weight would show an inverse relationship to hemoglobin concentration in a group of infants whose mothers had preeclampsia, where plasma volume constriction is common. METHODS Electronic and paper chart review identified 142 nulliparous women with preeclampsia (excluding HELLP syndrome). Birth weight percentile was determined based on cross-sectional hybrid growth curves. Maximal third trimester maternal hemoglobin concentrations were obtained and standardized to z-scores based on gestational age matched normative data. Birth weight percentile was examined as a function of hemoglobin z-score using appropriate statistics. RESULTS Average gestational age at delivery was 35.9±1.9 weeks. Mean birth weight percentile for infants of preeclamptic mothers was 34±32. Mean hemoglobin z-score for mothers with preeclampsia was 0.3±1.5, significantly higher than a control population (p = 0.04). Maternal hemoglobin z-score was inversely associated with birth weight percentile (r = − 0.18, P = 0.03). CONCLUSION Maternal hemoglobin concentrations are significantly elevated prior to delivery in women with preeclampsia. There is a statistically significant inverse correlation of maternal hemoglobin concentration to birth weight percentile.

Comparative Proteome Profile of Human Placenta from Normal and Preeclamptic Pregnancies

“…Placental dysfunction and increased inflammation are believed to underlie the pathogenesis of severe preeclampsia (PE), which may involve interleukin-induced signaling [54]. In addition, researches have shown that maternal hemoglobin concentrations are significantly changed prior to delivery in women with preeclampsia [55]. In this work, hemoglobin subunit zeta was found down regulated about 4.9 fold.…”

Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring

“…As we did not include pre‐eclampsia or maternal chronic conditions in this analysis, we cannot exclude their possible role in the development of asthma among offspring. However, pre‐eclampsia has been associated merely with high maternal hemoglobin levels during pregnancy . It is unlikely that pre‐eclampsia could explain the detected significant association between the risk of asthma among offspring and low maternal hemoglobin levels and anemia during pregnancy.…”

Association of glutathione S‐transferase theta 1 and glutathione S‐transferase mu 1 gene polymorphism with the risk of pre‐eclampsia during pregnancy in Bangladesh

“…Hemoglobin level is higher in control group when we compare it with the patient group ( P < 0.001). A study showed that maternal z score of hemoglobin was significantly higher in pre‐eclampsia patients compared to controls …”