Association of glutathione S‐transferase theta 1 and glutathione S‐transferase mu 1 gene polymorphism with the risk of pre‐eclampsia during pregnancy in Bangladesh

Abstract

GSTM1 null genotype increases the risk of pre-eclampsia. Combined GSTT1 and GSTM1 null genotype, the risk was even higher.

Lack of association between glutathione S‐transferase M1 and T1 gene polymorphisms and susceptibility to preeclampsia: An updated systematic review and meta‐analysis

“…Two studies were excluded due to repeated data, 35,36 eventually leaving 10 articles with sufficient data about genotype frequencies of both GST M1 and GST T1 deletion polymorphism in women with preeclampsia and healthy pregnant controls, which were included in the final review. [20][21][22][23][24][37][38][39][40][41] A detailed description of the characteristics extracted from the included studies is shown in Table 1. Out of 2831 participants included in this systematic review, 1259 were preeclampsia cases and 1572 were controls.…”

“…Five out of ten researches investigated frequencies of combined GST M1 and GST T1 genotypes. [20][21][22][23][24] Methodological rigor and quality were assessed using the STREGA recommendations. The total quality scores of the included studies ranged from 9 to 18 in the STREGA checklist.…”

“…were classified as medium (grade B), 20,23,[37][38][39]41 while four were scored 17,18 as high-quality studies (grade A). 21,22,24,40 No study was excluded due to low quality.…”

“…19 Several studies have also examined GST T1 and GST M1 deletion polymorphism in PE, with very conflicting results. [20][21][22][23][24] A study on Mexican Mestizo women showed susceptibility to PE among carriers of GST T1 null genotype. 20 Oppositely, a study on Chinese Han population of woman described a protective effect of GST T1 deletion.…”

“…21 GST M1 homozygous deletion was related to increased preeclampsia risk in Serbian and Bangladesh women. 22,23 After the publication of the first meta-analysis on the association between GSTM1 and GSTT1 gene polymorphisms and PE risk, in 2011, 24 several investigations on this topic on different populations were performed. Rather inconsistent results on the link between GST M1 and GST T1 polymorphisms and PE susceptibility were obtained, implying the necessity of an updated meta-analysis.…”