Worldwide Systematic Review of <i>GSTM1</i> and <i>GSTT1</i> Null Genotypes by Continent, Ethnicity, and Therapeutic Area

Nakanishi, Giovana; Pita-Oliveira, Murilo; Bertagnolli, Laísa S; Torres-Loureiro, Sabrina; Scudeler, Mariana M; Cirino, Heithor S; Chaves, Maria Laura; Miwa, Bruno; Rodrigues‐Soares, Fernanda

doi:10.1089/omi.2022.0090

Cited by 9 publications

(12 citation statements)

References 93 publications

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“…Also, it was reported that women who are HPV-positive and who carry both null genotypes present an increased risk of cervical carcinoma developing before the age of 40 years [69]. Our results do not show an association of GSTM1 or double mutants with cervical cancer or precursor lesions; GST-null mutants have been reported to be associated with oncologic diseases in general, though [70].…”

Section: Discussioncontrasting

confidence: 75%

Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes

Inácio,

Aguiar,

Rodrigues

et al. 2023

Antioxidants

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Human papillomavirus (HPV) infection is a necessary but not sufficient factor for the development of invasive cervical cancer (ICC) and high-grade intraepithelial lesion (HSIL). Oxidative stress is known to play a crucial role in HPV infection and carcinogenesis. In this study, we comprehensively investigate the modulation of HPV infection, HSIL and ICC, and ICC through an exploration of oxidative stress-related genes: CβS, MTHFR, NOS3, ACE1, CYBA, HAP, ACP1, GSTT1, GSTM1, and CYP1A1. Notably, the ACE1 gene emerges as a prominent factor with the presence of the I allele offering protection against HPV infection. The association of NOS3 with HPV infection is perceived with the 4a allele showing a protective effect. The presence of the GSTT1 null mutant correlates with increased susceptibility to HPV infection, HSIL and ICC, and ICC. This study also uncovers intriguing epistatic interactions among some of the genes that further accentuate their roles in disease modulation. Indeed, the epistatic interactions between the BB genotype (ACP1) and DD genotype (ECA1) were shown to increase the risk of HPV infection, and the interaction between BB (ACP1) and 0.0 (GSTT1) was associated with HPV infection and cervical lesions. These findings underscore the pivotal role of four oxidative stress-related genes in HPV-associated cervical lesions and cancer development, enriching our clinical understanding of the genetic influences on disease manifestation. The awareness of these genetic variations holds potential clinical implications.

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Section: Discussioncontrasting

confidence: 75%

Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes

Inácio,

Aguiar,

Rodrigues

et al. 2023

Antioxidants

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“…otype may be associated with susceptibility to certain tumors [45,48]. In our study, we found that the proportion of individuals with GSTT1 polymorphisms (present) in thyroid cancer patients was lower than that in the normal control group, but without statistical significance (Mean difference = 1.10, 95 % CI: 0.89-1.36, p = 0.37).…”

Section: Discussionmentioning

confidence: 48%

“…Literature reports have shown that the distribution of the GSTM1 null genotype frequency differs among different ethnic groups and populations in different regions [44]. In Western populations, the frequency of the GSTM1 null genotype is approximately 31-58 % [45]. In this study, the proportion of GSTM1 polymorphisms (present) in thyroid cancer patients was slightly lower than that of the normal control group, but without statistical significance (Mean difference = 0.85, 95 % CI: 0.71-1.01, p = 0.06).…”

Section: Discussionmentioning

confidence: 99%

“…GSTT1 primarily metabolizes small molecules such as vinyl epoxide, 1,3-butadiene, and monohalomethane found in tobacco smoke 47 . Toxicological studies have demonstrated that individuals with a GSTT1 null genotype are more likely to produce tissue-specific mutagens, suggesting that the GSTT1 null genotype may be associated with susceptibility to certain tumors 45 48 . In our study, we found that the proportion of individuals with GSTT1 polymorphisms (present) in thyroid cancer patients was lower than that in the normal control group, but without statistical significance (Mean difference=1.10, 95% CI: 0.89–1.36, p=0.37).…”

Section: Discussionmentioning

confidence: 99%

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Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis

Yang,

Liu,

Zhu

et al. 2023

Horm Metab Res

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Thyroid cancer is the most common malignant tumor of the endocrine system, and its incidence is increasing worldwide each year. This study aimed to explore the association between XRCC1, GSTM1, and GSTT1 polymorphisms in the model of thyroid cancer. The experiment was conducted by searching PubMed, Embase, and Web of Science, with the last search performed in March 2022. A total of 12 studies were included in this meta-analysis, with sample sizes ranging from 211 to 1124. The proportion of XRCC1 polymorphisms (rs25489, GG) in thyroid cancer was slightly lower than that of the normal control group, but the difference was not statistically significant (Mean difference=1.13, 95% CI: 0.99–1.28, p=0.08). The proportion of XRCC1 polymorphisms (rs25489, GA) in thyroid cancer was significantly lower than that of the normal control group (Mean difference=1.32, 95% CI: 1.16–1.52, p<0.00001). The proportion of XRCC1 polymorphisms (rs25489, AA) in thyroid cancer was slightly lower than that of the normal control group, but again, the difference was not statistically significant (Mean difference=0.78, 95% CI: 0.61–1.01, p=0.06). Similarly, the proportion of XRCC1 polymorphisms (rs25487, GG) and (rs25487, GA) in thyroid cancer was lower than that of the normal control group, but the differences were not statistically significant (p=0.22 and p=0.49, respectively). In conclusion, this study found that the proportion of XRCC1 polymorphisms (rs25489, AA) in thyroid cancer was lower than that of the normal control group.

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“…Many of them are characterized by genetic polymorphism that affects the functional activity of their alleles. There is evidence that the null allele of glutathione-S-transferase, which has an extended deletion, is associated with lung cancer, bladder cancer, breast cancer, and the development of endometriosis [ 14 ]. Many case-control studies revealed the associations of single nucleotide polymorphisms (SNPs) of genes participating in xenobiotic detoxification and antioxidant protection with a broad spectrum of multifactorial diseases.…”

Section: Introductionmentioning

confidence: 99%

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova,

Khamdiyeva,

Garshin

et al. 2023

Toxics

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The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms of genes involved in pesticide metabolism, detoxification, and antioxidant protection. Some of the selected polymorphisms also relate to susceptibility to cancer and cardiovascular, respiratory, and immune system diseases in individuals exposed to pesticides for a long time. For a case-control study of a unique cohort of people exposed to organochlorine pesticides for 10 years or more were chosen, a control cohort was selected that matched with the experimental group by the main population characteristics. PCR-PRLF and genome-wide microarray genotyping (GWAS) methods were used. We identified 17 polymorphisms of xenobiotic detoxification genes and 27 polymorphisms of antioxidant defense genes, which had a significantly high statistical association with the negative impact of chronic pesticide intoxication on human health. We also found 17 polymorphisms of xenobiotic detoxification genes and 12 polymorphisms of antioxidant defense genes that have a protective effect. Data obtained added to the list of potential polymorphisms that define a group at high risk or resistant to the negative effects of pesticides.

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Worldwide Systematic Review of GSTM1 and GSTT1 Null Genotypes by Continent, Ethnicity, and Therapeutic Area

Cited by 9 publications

References 93 publications

Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes

Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes

Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

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