GSTM1 null genotype increases the risk of pre-eclampsia. Combined GSTT1 and GSTM1 null genotype, the risk was even higher.

Background: Pseudomonas aeruginosa is a ubiquitous free-living bacterium and is responsible for severe nosocomial infections, life-threatening infections in immune compromised persons. The bacterium, along with its natural resistance, can acquire resistance to many antibiotics by a variety of methods.Method:Therefore, to compare the antibiotic sensitivity pattern of Pseudomonas aeruginosa, a total of seventeen isolates of P. aeruginosa were isolated from different sources; for example environmental sources, frozen food sources, clinical sources and medical waste materials. Isolates were confirmed to be P. aeruginosa by cultural and biochemical properties.Result:The isolates were tested against seventeen commercially available antibiotics to observe the antibiotic susceptibility patterns. Imipenem and meropenem were the most potent antibiotics (100% sensitivity) followed by amikacin and piperacillin with maximum sensitivity. Among others, gentamicin, ciprofloxacin, levofloxacin and aztreonam were found to be fairly active. A good number of isolates were intermediately resistant to ceftriaxone. The rates of resistance to aztreonam, cefotaxime and ceftazidime were 11.76%, 82.35% and 5.88% respectively. Complete resistance was observed against penicillin, ampicillin, cefixime and cefpodoxime.Conclusion:It can be concluded that the clinical isolates including isolate from medical waste, were multi-drug resistant than environmental and food isolates indicating the risk of transmission of resistance to the environmental isolates of P. aeruginosa.

Worldwide, pre‐eclampsia (PE) ranks as a major obstetric problem leading to substantial maternal and perinatal morbidity and mortality, especially in developing countries. Clinically it appears as a maternal syndrome, including hypertension and proteinuria after second half of pregnancy. PE affected by genetic trait, is associated with oxidative stress due to imbalance between the production of reactive oxygen species and the ability of antioxidant process. The glutathione S‐transferases (GST) are a group of enzymes which are involved in protecting cells from oxidative stress. In our study, we evaluated the risk of developing preeclampsia related to GSTT1 and GSTM1 genotypes. 104 patients having preeclampsia and 200 healthy controls having no history of preeclampsia were recruited for the study after getting written consent from them. DNA was extracted from the blood and Polymerase Chain Reaction (PCR) method was used to identify genotypes of GSTT1 and GSTM1 in study subjects. We used odds ratio to calculate the risk between cases and controls using SPSS 17. Genotype frequency of GSTM1 nul genotype showed significant difference between case and control group (p<0.001). Combined null genotype for GSTT1 and GSTM1 showed significant difference between two groups when compared to combined present genotype for GSTT1 and GSTM1 (p<0.001). There was significant association for GSTM1 null genotype with the development of preeclampsia (p<0.001) and the odds ratio was significantly higher in patients compared to control subjects (OR=4.75; 95% CI=2.17–10.39). For GSTT null genotype, there was increased risk for developing preeclampsia but the association was not significant (OR=1.22; 95% CI=0.58–2.57).In case of GSTT1 and GSTM1 combined genotype, patients having both null genotypes for GSTT1 and GSTM1 showed significance (p<0.001) and higher risk of developing preeclampsia when compared to control subjects (OR=7.64; 95% CI=2.38–24.60). We found a significant association between GSTM1 null genotype and the risk of developing preeclampsia in Bangladeshi population. No risk was found for GSTT1 null genotype and preeclampsia. For combined null genotype of GSTT1 and GSTM1, the risk was even higher relative to the risk of either GSTT1 null or GSTM1 null genotype alone.Support or Funding InformationDear colleague, I hereby, would like to express my motivation with this letter to attend the American Society for Biochemistry and Molecular Biology at San Diego, USA from 21–25 April 2018.The conference topics are relevant to my professional skills, and therefore I would welcome the opportunity to attend this conference having researchers from different countries of the world. I am working as an program coordinator at RHSTEP and at the same working as a predatory PhD student at Department of Biochemistry and Molecular Biology of Dhaka University.As a unique added value of this event, I will find a chance for networking with other scientists from different countries, which is an excellent opportunity for horizontal exchange of knowledge and experience. This networking will expand my opportunities for planning collaborative research projects in future.I have completed my MBBS from Moulana Bhasani Medical College and MPH from American International University, Bangladesh. In case of all three degrees, the medium of instruction was English.Unfortunately I do not have fund to attend this conference and I will apply for a travel grant.My attendance at this training will be very helpful for my carrier development and I would highly appreciate to be one of the selected participants.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

A 30-year-old man, who had no travel history to COVID-19 prone areas whereas he had the characteristics signs and symptoms of COVID-19. Chest X-ray and rRT-PCR revealed his confirmed COVID-19. This study recommends the early identification and management of COVID-19.

Background: Worldwide diarrheal disease is the second leading cause of death in under-five years children. In Bangladesh diarrhoea kills half million under-five children every year second to pneumonia. The study was aimed to assess the domestic hygiene practices and find the factors that risked for diarrheal disease in under-five children among the families that resides in isolated chars of Gaibandha district.Method: A community based cross-sectional study design was employed in 2011 at three unions of Gaibandha district. Random sampling technique was employed to select 322 households that had at least one under-five children. Data was collected using pretested structured questionnaire.Result: A total of 322 children were enrolled. The overall diarrhoea prevalence was 20.8%. About 71% (n=255) of households collected drinking water from improved water sources and only 10.8% (n=17) had been using river water for their cooking. We found a lower prevalence of diarrhoea in children whose mother had a higher education level. More than 60% mothers didn't wash their hands before feeding their children. A good scenario has been observed that babies were breastfed for sufficient time period. Apart from diarrhoea, Otitis media and skin diseases were significantly found in chars babies. About 20% of the babies were found not immunized and 43.2% found immunized and over 40% partially immunized. Half of the families were found deprived from primary health care facilities and there were found only one satellite clinic in the study sites. Conclusion:The level of diarrheal disease variation was varied due to maternal education, socio-economic status, personal hygiene, waste disposal system and public awareness. Thus enhancing community based behavioural change communication that emphasize on personal hygiene and sanitation should be strengthening to reduce childhood diarrhoea.