Maternal environment and the reproductive function of the offspring

Dupont, Charlotte; Cordier, Anne; Junien, Claudine; Mandon‐Pepin, Béatrice; Lévy, Rachel; Chavatte‐Palmer, Pascale

doi:10.1016/j.theriogenology.2012.06.016

Cited by 64 publications

(48 citation statements)

References 81 publications

(94 reference statements)

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“…Our research suggests more attention should be given to the reproductive capacity of patients with CPT1A deficiency and other inherited defects in mitochondrial fatty acid degradation. Recently, there is increasing evidence that maternal malnutrition during fetal development adversely affects the long-term health of her offspring, including reduced fertility; 24,25 however, underlying mechanisms remain undetermined. Notably, a marked reduction in CPT1 expression was observed in the offspring of rats provided with a malnutrition diet during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Fatty acid degradation plays an essential role in proliferation of mouse female primordial germ cells via the p53-dependent cell cycle regulation

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Fatty acid degradation plays an essential role in proliferation of mouse female primordial germ cells via the p53-dependent cell cycle regulation

et al. 2016

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“…The longstanding developmental origins of adult health and disease hypothesis have received support from recent research of non-genetic influences on offspring, including epigenetic changes (Barouki et al, 2012;Juul et al, 2014). Data suggest an influence of the uterine environment on reproductive health in offspring, through various processes (Jensen et al, 2004;Ravnborg et al, 2011;Dupont et al, 2012). In animal studies, Sertoli cell development and, potentially, sperm production, are affected by maternal nutrition during pregnancy (Olsen et al, 2000;Genovese et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Paternal lifestyle, behavior and environmental exposure may impact offspring as well (McPherson et al, 2014;Soubry et al, 2014). However, evidence from epidemiologic studies of peri-conceptional effects on offspring reproductive function is limited and equivocal (Power et al, 2003;Dupont et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Male birthweight, semen quality and birth outcomes

et al. 2017

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STUDY QUESTION: What are the relations among birthweight (BW), semen parameters and birth outcomes in a population-based sample?SUMMARY ANSWER: BW is unrelated to semen parameters, which are in turn unrelated to birth outcomes. WHAT IS KNOWN ALREADY:In clinical settings, there has been suggestion that semen parameters are related to BW when comparing fertile and infertile men; however, findings have been less clear in more general populations.STUDY DESIGN, SIZE, DURATION: Questionnaire data and semen samples were collected at baseline from 427 male participants of the population-based Longitudinal Investigation of Fertility and the Environment (LIFE) prospective cohort study from 2005 to 2009, who were followed prospectively to assess pregnancy outcomes among 226 singleton births. PARTICIPANTS/MATERIALS, SETTING, METHODS:Men of at least 18 years of age who were married or in a committed relationship and trying to conceive were eligible for participation; physician-diagnosed infertility was an exclusion criterion. Participants were recruited from two geographic areas and semen samples were analyzed for 34 quality parameters categorized as general, motility, morphology, sperm head and sperm chromatin structure using methods including computer-aided semen analysis integrated visual optical system and sperm chromatin structure assay. Linear and mixed models were used for statistical analysis of the relations between men's BW, semen parameters, and BW, gestational age at delivery, birth length, head circumference and ponderal index of singleton births. MAIN RESULTS AND THE ROLE OF CHANCE:No association was observed between male BW and semen parameters or birth outcomes. Few associations were observed between semen parameters and birth outcomes, and the observed statistically significant associations were isolated and without a consistent pattern that would suggest an association between BW and birth outcomes.LIMITATIONS, REASONS FOR CAUTION: Men's BW was self-reported and may be subject to some imprecision. Semen analysis was performed the day after collection, an approach that impacts the assessment of motility and that may limit inference from our analyses of motility measures. In addition, inclusion criteria for selection into the cohort limits generalizability to generally healthy couples trying to conceive and without known subfertility. WIDER IMPLICATIONS OF THE FINDINGS:Despite suggestions from prior studies of male in utero exposures impacting BW and male reproductive health, there appears to be little support for such relations in this generally healthy population.

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“…Cette revue décrit les moyens de préven-tion possible de la programmation périnatale des maladies chroniques de l'adulte. < développementales et même, des troubles du comportement alimentaire, une altération des fonctions de reproduction et le développement de cancers [1]. Un petit poids de naissance peut être le fait d'une naissance prématurée (< 37 semaines de gestation).…”

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“…Elle augmente en partie du fait d'un nombre plus important de naissances prématurées provoquées, de la hausse de l'âge maternel moyen, de l'augmentation du recours à la procréation médicalement assistée et des grossesses multiples liées à ces techniques. Un petit poids de naissance peut aussi être secondaire à un ralentissement de la croissance foetale : on parle alors de retard de croissance intra-utérin (RCIU) lorsque le poids de naissance est inférieur au 10 e percentile 1 . Les premières études épidémiologiques qui montraient un lien entre petit poids de naissance et survenue de maladies chroniques de l'adulte ne distinguaient pas les origines du petit poids de naissance.…”

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