Fatty acid degradation plays an essential role in proliferation of mouse female primordial germ cells via the p53-dependent cell cycle regulation

Teng, Hui; Sui, Xuesong; Zhou, Cheng; Shen, Cong; Yang, Ye; Pang, Zhiyong; Guo, Xuejiang; Huo, Ran

doi:10.1080/15384101.2015.1127473

Cited by 21 publications

(12 citation statements)

References 28 publications

(28 reference statements)

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“…Germ cells are known to have a distinct metabolic profile from somatic cells, and this difference is related to their pluripotent stem cell-like properties, and to the requirements of their migratory properties [85, 86]. Potentially related to this we have found that a Nasonia insulin-like growth factor I mRNA is localized to the oosome.…”

Section: Discussionmentioning

confidence: 93%

Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the waspNasonia vitripennis

Quan

Lynch

2018

Preprint

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BackgroundThe oosome is the germline determinant in the wasp Nasonia vitripennis and is homologous to the polar granules of Drosophila. Despite a common evolutionary origin and developmental role, the oosome is morphologically quite distinct from polar granules. It is a solid sphere that migrates within the cytoplasm before budding out and forming pole cells.ResultsTo gain an understanding of both the molecular basis of the novel form of the oosome, and the conserved essential features of germ plasm, we quantified and compared transcript levels between embryo fragments that contained the oosome, and those that did not. The identity of the localized transcripts indicated that Nasonia uses different molecules to carry out conserved germ plasm functions. In addition, functional testing of a sample of localized transcripts revealed potentially novel mechanisms of ribonucleoprotein assembly and pole cell cellularization in the wasp.ConclusionsOur results demonstrate that numerous novel and unexpected molecules have been recruited in order produce the unique characteristics of the oosome and pole cell formation in Nasonia. This work will serve as the basis for further investigation into the patterns of germline determinant evolution among insects, the molecular basis of extreme morphology of ribonucleoproteins, and the incorporation of novel components into developmental networks.

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Section: Discussionmentioning

confidence: 93%

Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the waspNasonia vitripennis

Quan

Lynch

2018

Preprint

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“…Germ cells are known to have a distinct metabolic profile from somatic cells, and this difference is related to their pluripotent stem cell-like properties, and to the requirements of their migratory properties [80, 81]. Potentially related to this, we have found that a transcript encoding an insulin homolog ( Nv-igf ) is localized to the oosome (Fig.…”

Section: Discussionmentioning

confidence: 94%

Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the wasp Nasonia vitripennis

2019

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Background The oosome is the germline determinant in the wasp Nasonia vitripennis and is homologous to the polar granules of Drosophila. Despite a common evolutionary origin and developmental role, the oosome is morphologically quite distinct from polar granules. It is a solid sphere that migrates within the cytoplasm before budding out and forming pole cells. Results To gain an understanding of both the molecular basis of oosome development and the conserved essential features of germ plasm, we quantified and compared transcript levels between embryo fragments that contained the oosome and those that did not. The identity of the differentially localized transcripts indicated that Nasonia uses a distinct set of molecules to carry out conserved germ plasm functions. In addition, functional testing of a sample of localized transcripts revealed potentially novel mechanisms of ribonucleoprotein assembly and pole cell cellularization in the wasp. Conclusions Our results demonstrate that the composition of germ plasm varies significantly within Holometabola, as very few mRNAs share localization to the oosome and polar granules. Some of this variability appears to be related to the unique properties of the oosome relative to the polar granules in Drosophila, and some may be related to differences in pole formation between species. This work will serve as the basis for further investigation into the patterns of germline determinant evolution among insects, the molecular basis of the unique properties of the oosome, and the incorporation of novel components into developmental networks.

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“…TP53 , gradually upregulated in the IR heart, is key for heart disease progression. A number of studies have suggested that TP53 serves an important role in heart remodeling and heart failure, and is responsible for suppression of hypoxia inducible factor 1-induced angiogenesis, apoptosis of cardiomyocytes and fatty acid metabolism ( 39 – 41 ). Plk2 , upregulated in the day 7 heart, is a member of the serine/threonine protein kinases.…”

Section: Discussionmentioning

confidence: 99%

Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium

et al. 2018

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Acute myocardial infarction induces ventricular remodeling, which is implicated in dilated heart and heart failure. The pathogenical mechanism of myocardium remodeling remains to be elucidated. The aim of the present study was to identify key genes and networks for myocardium remodeling following ischemia-reperfusion (IR). First, the mRNA expression data from the National Center for Biotechnology Information database were downloaded to identify differences in mRNA expression of the IR heart at days 2 and 7. Then, weighted gene co-expression network analysis, hierarchical clustering, protein-protein interaction (PPI) network, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were used to identify key genes and networks for the heart remodeling process following IR. A total of 3,321 differentially expressed genes were identified during the heart remodeling process. A total of 6 modules were identified through gene co-expression network analysis. GO and KEGG analysis results suggested that each module represented a different biological function and was associated with different pathways. Finally, hub genes of each module were identified by PPI network construction. The present study revealed that heart remodeling following IR is a complicated process, involving extracellular matrix organization, neural development, apoptosis and energy metabolism. The dysregulated genes, including SRC proto-oncogene, non-receptor tyrosine kinase, discs large MAGUK scaffold protein 1, ATP citrate lyase, RAN, member RAS oncogene family, tumor protein p53, and polo like kinase 2, may be essential for heart remodeling following IR and may be used as potential targets for the inhibition of heart remodeling following acute myocardial infarction.

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Fatty acid degradation plays an essential role in proliferation of mouse female primordial germ cells via the p53-dependent cell cycle regulation

Cited by 21 publications

References 28 publications

Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the waspNasonia vitripennis

Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the waspNasonia vitripennis

Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the wasp Nasonia vitripennis

Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium

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