Marine microbial alkaline protease: An efficient and essential tool for various industrial applications

Marine Microbial Fibrinolytic Enzymes: An Overview of Source, Production, Biochemical Properties and Thrombolytic Activity

“…Even though these enzymes have been characterized from a wide range of different sources, microbial fibrinolytic enzymes are considered attractive tools due to their features, such as enhanced specificity [8], low production cost [8], comparatively high yield [28] and the possibility to be genetically modified by recombinant DNA technology and protein engineering approaches [29]. Marine ecosystems serve as a reservoir of microorganisms producing important therapeutic metabolites, especially enzymes [30][31][32][33][34][35][36][37][38][39], but they remain largely unexplored to date. Due to the wide biodiversity of the marine environment, marine microorganisms can provide a diverse array of enzymes for biotechnological development, with possible improved pharmacological properties and lesser side effects [40].…”

Identification and Verification of the Prodigiosin Biosynthetic Gene Cluster (BGC) in Pseudoalteromonas rubra S4059

“…Previous proteomic analysis on P. rubra S4059 ( 20 ) (data are available via ProteomeXchange with identifier PXD023249) indicated that the strain produced several proteases that may have the same antibacterial function as that described in P. piscicida ( 25 ). Further studies with the molecular weight cutoff and protein analyses found that the antimicrobial activities may also be due to extracellular proteases/peptidases, which were often secreted by marine bacteria and reported with potent antibacterial activity ( 31 – 33 ).…”

Exoproduction and Biochemical Characterization of a Novel Thermophilic Serine Protease From Ornithinibacillus Caprae L9T With Hide-dehairing Activity

“…Enzymatic dehairing, which has been proved to be the most cost-effective and eco-friendly process, exerts tremendous potential in obtaining high-quality leather (Wang et al 2009). This phenomenon has increased the attention toward the exploitation of enzyme-producing microorganisms (Barzkar 2020). So far, a variety of extracellular proteases have been reported and characterized from different microorganisms, including fungi like Paecilomyces marquandii (Gradisar et al 2005), and bacteria, such as Bacillus subtilis (Dettmer et al 2013), Lactobacillus curvatus (Sun et al 2019), Nocardiopsis dassonvillei (Sharma et al 2020) and Streptomyces koyangensis (Ben Elhoul et al 2015).…”