Marburg experiment on surgical research: A five-years' experience on the cooperation between clinical and theoretical surgeons

Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

“…The study ran from April 30th, 1973 till September 9th, 1973, and, at the exception of the radiological and microscopical examinations it was carried out exclusively by our working group for gastric disease. This group for the purposes of the study, consisted of two clinical surgeons, two theoretical surgeons (for definition see Lorenz et al, 1976a), four technicians and one medical student.…”

Histamine and stress ulcer: New components in organizing a sequential trial on cimetidine prophylaxis in seriously Ill patients and definition of a special group at risk (severe polytrauma)

“…In three sessions of our weekly seminar for training in surgical research [63] questions, design, methods, risks and ethical problems of the trial were discussed with all clinicians and basic research scientists in the Department who finally agreed, tn two additional meetings the nurses and technicians of the intensive care unit and the anesthesiologists were informed and convinced in the same way.…”

“…For the trial period an executive group was defined consisting of 6 clinical and 2 theoretical surgeons [63]. It included the 2 academic members of the small working group for stress ulcer [63], the chairmen of the 2 Units, 2 consultants and 2 senior registrars.…”

“…It included the 2 academic members of the small working group for stress ulcer [63], the chairmen of the 2 Units, 2 consultants and 2 senior registrars. To reduce observer variation [43] all members of the group had been trained in systematic follow-up [91] and endoscopy during a 3-year prospective trial [92].…”

“…Because of the expectedly high lethality rate the team met every fortnight to decide whether the trial should be continued or stopped. Furthermore, the staff of the clinic was informed and motivated again and again in our weekly seminar for training in surgical research [63].…”