Histamine and stress ulcer: New components in organizing a sequential trial on cimetidine prophylaxis in seriously Ill patients and definition of a special group at risk (severe polytrauma)

Lorenz, W.; Fischer, Marlene; Rohde, H.; Troidl, H.; Reimann, H. J.; Ohmann, Christian

doi:10.1007/bf01478603

Cited by 35 publications

(5 citation statements)

References 59 publications

(41 reference statements)

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“…Diseases with elevated plasma histamine levels have to be considered in patients entering the operating theatre (Table 8). These are mostly emergency cases such as those with poly trauma (LORENZ et al 1980b, LORENZ andDOENICKE 1985a), septic shock (Fig. 6), upper gastrointestinal bleeding (SATfLER et al 1990) and severe intestinal hypoxia, e.g.…”

Section: Surgical Manoeuvres and Other Physical And Chemical Meamentioning

confidence: 98%

Histamine in Anaesthesia and Surgery: Causality Analysis

Lorenz¹,

Dietz²,

Ennis³

et al. 1991

Histamine and Histamine Antagonists

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Section: Surgical Manoeuvres and Other Physical And Chemical Meamentioning

confidence: 98%

Histamine in Anaesthesia and Surgery: Causality Analysis

Lorenz¹,

Dietz²,

Ennis³

et al. 1991

Histamine and Histamine Antagonists

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“…Examples of the latter were those on stress ulcer prophylaxis in polytrauma [16] or on the preanesthetic administration of histamine receptor blockers [17].…”

Section: Contributions To Clinical Trialsmentioning

confidence: 99%

“…The Institute of Theoretical Surgery has been instrumental in designing and supervising a number of controlled clinical trials, some of which were generated as a perceived need to fill in gaps in decision making algorithms. Examples of the latter were those on stress ulcer prophylaxis in polytrauma [16] or on the preanesthetic administration of histamine receptor blockers [17].…”

Section: Contributions To Clinical Trialsmentioning

confidence: 99%

Theoretical surgery: A new specialty in operative medicine

Lorenz

Rothmund

1989

World j. surg.

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Theoretical surgery is defined as a nonoperative decision analysis and clinical and basic research supporting system for surgery. It developed to meet the needs of academic surgeons to coordinate communication with basic science disciplines.This article summarizes the development of this idea at the University of Marburg where theoretical surgery has reached departmental and institutional proportions. Its objectives and methods are described. Central to its operation are permanent working teams of 2 clinical surgeons, 1 basic scientist (theoretical surgeon), 1-2 technicians, and 1-2 students focusing on one problem in a joint interdisciplinary manner. Decision analysis with classification methods and the creation of decision trees and algorithms are central to the operation of this experiment.Lessons learned from this academic experiment and the accomplishments during the past 20 years are summarized on 3 levels of efficacy: performance, changing strategies, and outcome.

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“…Materials and methods of all these trials have been described in previous communications [4,9,10,13]. In Table I.…”

Section: Histamine-release Responses In Clinical Conditionsmentioning

confidence: 99%

“…In a general hospital, these patients will comprise about 30 % of all patients admitted for surgery [9].…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

Anti H1- and anti H2-premedication

Doenicke¹,

Lorenz

1985

Annales Françaises d'Anesthésie et de Réanimation

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Histamine-release responses in clinical conditionsshow a wide range of severity, from a single spot of erythema or a wheal up to a life-threatening reaction or the death of the patient.To demonstrate the efficiency of Hi-and HE-blockade in preventing histamine-induced anaphylactic and anaphylactoid reactions, a series of controlled trials was carried out in patients, volunteers and dogs presenting histamine-release responses of all three grades of severity (table I). Both the histamine-releasing drugs and the histamine H1-and HE-receptor antagonists had to be chosen for these trials according to a series of well-conceived and strict criteria.For the histamine H1-and HE-receptor antagonists, the criteria for selection included potency, selectivity, duration of action, clinical experience with the drug and the availability both for tlae oral and the intravenous routes. For the HE-receptor antagonist, selection was not difficult since, at the time of the first trials, cimetidine was the only available drug on the market. However, the choice of the Hi-receptor antagonist was very difficult.

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Histamine and stress ulcer: New components in organizing a sequential trial on cimetidine prophylaxis in seriously Ill patients and definition of a special group at risk (severe polytrauma)

Cited by 35 publications

References 59 publications

Histamine in Anaesthesia and Surgery: Causality Analysis

Histamine in Anaesthesia and Surgery: Causality Analysis

Theoretical surgery: A new specialty in operative medicine

Anti H1- and anti H2-premedication

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