Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

Histamine and stress ulcer: New components in organizing a sequential trial on cimetidine prophylaxis in seriously Ill patients and definition of a special group at risk (severe polytrauma)

“…In the prophylaxis and treatment of acute gastroduodenal lesions, however, the advantages of cimetidine have only been suggested by the results of animal experiments [14, 86, I00], clinical case reports [6,24,75,94], retrospective trials and prospective trials using either historical controls [13,52,82,107] or patients from highly selected groups [25,26,30,42,76,112]. Since histamine H2-receptors in acid secretion [9] and microcirculation [41] and histamine release from intra-and extragastric cellular stores [64,65,105,106] are likely to play an important role in the pathogenesis of acute as well as chronic gastroduodenal ulceration it could be expected that therapy using H2-receptor antagonism could offer clinical advantages to patients likely to or developing stress ulcerations.…”

“…(2) "Acute ulceration": within the next hour after detecting the clinical symptoms of bleeding or perforation urgent endoscopy using a transportable endoscopy unit [105] or X-rays for showing free air in the abdomen were performed in all cases. If lesions were detected they were characterized by assessing their type [90], number, bleeding activity [34], localization and expansion.…”

Marburg experiment on surgical research: A five-years' experience on the cooperation between clinical and theoretical surgeons

“…On the contrary, there was increasing integration between the clinical and basic-science parts of the research in the teams. It became more and more impossible for publications to be written solely by either the clinical or the theoretical surgeon when, for example, problems of clinical diagnosis coincided with problems of clinicalchemical measurements (Troidl et al, 1976). An essential step from cooperation to integration has thus been made, there is increasing evidence that this process is selfperpetuating in each small working team.…”

“…organising the collection of samples of blood or tissue in the clinic, but the making of appointments with volunteers and the sampling at endoscopy proved a way out of the dilemma (Lorenz et al, t976a; Troidl et al, 1976).…”

“…When we discovered that in contrast to guineapigs human subjects were to be understood as historical beings we felt almost as if we had broken through intellectually into a new dimension. For example, while analysing the data about the histamine content of the gastric mucosa of control subjects and of patients with duodenal ulcer (Troidl et al, 1976) was exemplified this problem by the following question: -Is a patient still a normal subject when his case history once showed a gastritis? If not, where can control subjects be found, considering that gastritis occurs so often?…”