Manifestations of renal cell carcinom

Gibbons, Robert P.; Montie, James E.; Correa, Roy J.; Mason, J. Tate

doi:10.1016/0090-4295(76)90366-6

Cited by 61 publications

(29 citation statements)

References 62 publications

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“…Only 10% of individuals with RCC present with the classic triad of hematuria, pain and a flank mass and these individuals most often have advanced disease. More than 40% of individuals with RCC present with none of these three symptoms [5]. Currently, more than 60% of RCC are detected incidentally in patients not suspected of harboring a genitourinary malignancy.…”

Section: Incidence Risk Factors and Clinical Featuresmentioning

confidence: 99%

Renal cell carcinoma

Cairns

2011

CBM

397

303

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Renal Cell Carcinoma (RCC) has the highest mortality rate of the genitourinary cancers and the incidence of RCC has risen steadily. If detected early, RCC is curable by surgery although a minority are at risk of recurrence. Increasing incidental detection and an ageing population has led to active surveillance as an option for patients with small renal masses. RCC is heterogeneous and comprises several histological cell types with different genetics, biology and behavior. The identification of the genes predisposing to inherited syndromes with RCC has provided much of our knowledge of the molecular basis of early sporadic RCC. Many of the oncogenes and tumor suppressor genes that are mutated leading to pathway dysregulation in RCC remain to be elucidated. Global studies of copy number, gene sequencing, gene expression, miRNA expression and gene methylation in primary RCC will lead towards this goal. The natural history of RCC indicated by candidate precursor lesions, multifocal or bilateral disease, growth rate of small renal masses under surveillance, and high risk populations provide insight into the behavior of this disease. The use of molecular markers for early detection and prognosis merits more attention with ongoing advances in omics technologies. This review focuses on early RCC, that is disease confined within the renal capsule.

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Section: Incidence Risk Factors and Clinical Featuresmentioning

confidence: 99%

Renal cell carcinoma

Cairns

2011

CBM

397

303

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“…It is widely known that up to 70% of pulmonary emboli occur as a complication of lower limb deep vein thrombosis, and ultrasonography examination is the first choice modality for screening venous thrombi. However, abdominal ultrasonography can also be useful for screening venous thrombi (9,10). In the present case, the asymptomatic, large, renal tumor was clearly identified by abdominal ultrasonography examination as a space-occupying phenomenon in the left renal area.…”

Section: Discussionmentioning

confidence: 69%

“…The early symptoms of RCC are uncharacteristic and vary among individuals, which often leads to false and/or misdiagnosis (10). Only 10% of patients with RCC present with the three characteristic clinical symptoms observed during early stages, including hematuria, abdominal pain and an abdominal mass, whereas >40% of patients do not present with these symptoms (10).…”

Section: Discussionmentioning

confidence: 99%

Multiple pulmonary emboli as a result of renal cell carcinoma: A case report

Zeng

Ding

et al. 2016

Oncology Letters

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Abstract. Pulmonary embolism is the most prevalent and potentially fatal complication of deep vein thrombosis. Renal cell carcinoma (RCC) is occasionally associated with pulmonary embolism, occurring as a result of secondary hypercoagulable states or cancer-associated emboli. The current study describes the case of a 43-year-old male that experienced 'squeezing' pain in the chest, considered to mimic acute coronary syndrome. Following a number of diagnostic examinations, the patient was diagnosed with pulmonary embolism, which led to the detection of RCC. The patient did not experience any symptoms until the diagnosis of pulmonary embolism, therefore the asymptomatic tumor was considered as one of the possible causes. Abdominal ultrasonography examination is highly recommended for screening in all patients, particularly those that exhibit uncharacteristic symptoms, to improve the detection and diagnosis of RCC and associated pulmonary emboli.

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“…Vezano uz razvoj dijagnostičkih modaliteta ide i porast broja pacijenata s KB-om koji pri postavljanju dijagnoze nisu imali simptome vezane uz osnovnu bolest. Klasičan trijas simptoma kod pacijenata s KB-om je makrohematurija, palpabilna tvorba i bolovi 9 . No taj trijas se u današnje vrijeme rijetko vidi.…”

Section: Raspravaunclassified

Incidence, clinical evaluation and surgical treatment of patients with renal cell cancer: 40-years of experience in the University Hospital Rijeka

et al. 2017

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Sažetak. Cilj: Ispitati učestalost, kliničku evaluaciju i kirurško liječenje pacijenata s karcinomom bubrega (KB). Pacijenti i metode: Retrospektivnim istraživanjem bili su obuhvaćeni svi pacijenti u Kliničkom bolničkom centru Rijeka koji su između 1. siječnja 1972. i 31. prosinca 2012. godine operirani zbog KB-a. Rezultati: U promatranom razdoblju u našem centru zbog KB-a bilo je operirano 1045 pacijenata. Broj pacijenata se tijekom vremena povećao, s 5 pacijenata godišnje početkom 70-ih godina na preko 50 posljednjih nekoliko godina. Broj asimptomatskih pacijenata povećao se s 6 % na 75 %. Prosječna dob pacijenata bila je 63 godine (raspon 21 -86 godina). Nefrektomija je učinjena u 95,3 % pacijenata, u 2,6 % parcijalna nefrektomija, a u 2,1 % eksplorativna lumbotomija. U promatranom razdoblju 5-godišnje preživljenje bilo je u 64 %, a 10-godišnje preživljenje 47 %. Zaključak: Učestalost KB-a se tijekom posljednja četiri desetljeća višestruko povećala. Novije dijagnostičke metode omogućuju njegovo otkrivanje u ranijoj fazi, a samim time se omogućuje poštednije kirurško liječenje, ne umanjujući onkološki učinak.Ključne riječi: incidencija; karcinom bubrega; nefrektomija; parcijalna nefrektomija; preživljenje Abstract. Aim: To evaluate incidence, clinical evaluation and surgical treatment of our patients with renal cell cancer (RCC). Patients and methods: We retrospectively analyzed all patients with RCC operated in University Hospital Rijeka from January 1 st 1972 to December 31 st 2012. Results: In observed period 1045 patients were operated because of RCC. Number of operated patients has increased during time from 5 in the begining of 70-ties to more than 50 in the few last years. The number of asymptomatic patients has increased from 6% to 75%. The mean age was 63 years (range 21-86). Nephrectomy wasperformed in 95.3% patients, nephron sparing surgery in 2.6% and explorative lumbotomy in 2,1% of patients. The 5-year survival was 64% and 10-year survival 47%. Conclusion: The incidence of RCC substantialy increased during time. The new diagnostic methods found RCC in earlier phase and the nephron sparing surgery can be performed without negative influence on oncological outcome.

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Manifestations of renal cell carcinom

Cited by 61 publications

References 62 publications

Renal cell carcinoma

Renal cell carcinoma

Multiple pulmonary emboli as a result of renal cell carcinoma: A case report

Incidence, clinical evaluation and surgical treatment of patients with renal cell cancer: 40-years of experience in the University Hospital Rijeka

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