Management of Lipids in Patients with Diabetes

Mbue, Ngozi D.; Mbue, John E.; Anderson, Jane

doi:10.1016/j.cnur.2017.07.009

Cited by 10 publications

(8 citation statements)

References 69 publications

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“…On the other hand, T2DM patients usually suffer from dyslipemia, which includes quantitative, qualitative and kinetic lipoprotein abnormalities that, together, result in a shift towards a more atherogenic lipid profile [ 6 , 7 ]. These alterations are generally characterized in man by an increase in the level of very low-density lipoproteins (VLDL), small and dense low-density lipoproteins (LDL), as well as a high content of triglycerides in LDL and high-density lipoproteins (HDL), and an increased susceptibility of LDL to oxidation [ 6 , 8 ]. In previous studies, we observed that dietary cholesterol greatly increased the amount of plasma cholesterol in rodents giving rise to an increase of VLDL and LDL-cholesterol-enriched particles and to a decrease of HDL-cholesterol [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

et al. 2019

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Carob fruit extract (CFE) has shown remarkable in vitro antioxidant properties and reduces postprandial hyperglycemia and hyperlipidemia in healthy animals. Development of functional meat products that contain bioactive components are presented as a great nutritional strategy. Until now, the effect of the consumption of restructured meat enriched with CFE in a murine model of diabetes has not been investigated. The objective of this study was to evaluate the effect on glycemia, lipemia, lipoprotein profile, Ldlr, arylesterase (AE), and very low-density lipoproteins (VLDL) and liver oxidation in streptozotocin-nicotinamide (STZ-NAD) growing Wistar diabetic rats fed restructured meat in the frame of a high cholesterol/high saturated-fat diet. In the present study, three groups (D, ED and DE) were fed cholesterol-enriched (1.4% cholesterol and 0.2% cholic acid) and high saturated-fat diets (50% of total energy from fats and 20.4% from saturated fatty acids). Rats were subjected to a STZ-NAD administration at the 3rd week. Group D did not receive CFE, while ED and DE rat groups received CFE before and after the diabetic induction, respectively. After eight weeks, D rats showed hyperglycemia and hypercholesterolemia, an increased amount cholesterol-enriched VLDL (β-VLDL), IDL and LDL particles and triglyceride-enriched HDL. ED and DE partially blocked the hypercholesterolemic induction with respect to D group (p < 0.001) and improved glycemia, cholesterol levels, lipoprotein profile, Ldlr, plasma AE activity and liver oxidation (p < 0.001). Fecal fat, moisture and excretion were higher while dietary digestibility was lower in ED and DE vs. D counterparts (p < 0.0014). In conclusion, CFE-enriched meat shows, for the first time, hypoglycemic and hypolipidemic effects in STZ-NAD animals fed high cholesterol/high saturated-fat diets. Likewise, it manages to reverse possible diabetes lipoprotein alterations if CFE-enriched meat is consumed before pathology development or improves said modifications if Type 2 Diabetes Mellitus is already established.

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Section: Introductionmentioning

confidence: 99%

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

et al. 2019

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“…As hyperglycemia is the most characteristic feature of T2DM, we analyzed its effects in isolation, which is a simplistic representation of a complex disease process. T2DM is a complicated disease with a series of metabolic changes that include hyperinsulinemia and hyperlipidemia [27]. These other metabolic disorders should be included in future in vivo studies of hyperglycemia on DLBCL.…”

Section: Discussionmentioning

confidence: 99%

High Glucose Promotes Epithelial-Mesenchymal Transition, Migration and Invasion in A20 Murine Diﬀuse Large B-Cell Lymphoma Cells Through Increased Expression of High Mobility Group AT-Hook 2 (HMGA2)

Tan

et al. 2019

Med Sci Monit

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Background Patients with type 2 diabetes mellitus have been reported to be at increased risk of developing non-Hodgkin’s lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common type of high-grade NHL. This study aimed to investigate the effects of high glucose on cell migration, invasion and epithelial-mesenchymal transition (EMT), and the expression of high mobility group AT-hook 2 (HMGA2) in A20 murine DLBCL cells. Material/Methods Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were used to analyze the expression of HMGA2 at the gene and protein level and EMT markers in the A20 murine DLBCL cell line. A transwell assay evaluated cell migration and invasion of A20 cells. Short-interfering RNA (siRNA) was used to knockdown HMGA2 expression. Results High glucose levels upregulated the expression of HMGA2, induced phenotypic changes of EMT, and increased cell migration and invasion in A20 cells. Knockdown of HMGA2 by siRNA effectively inhibited EMT induced by high glucose in A20 cells by directly regulating the Wnt/β-catenin signaling pathway. Conclusions In the A20 murine DLBCL cell line, high glucose upregulated the expression of HMGA2 to induce EMT and promote cell migration and invasion through the Wnt/β-catenin signaling pathway.

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“…Disorders of lipid metabolism (e.g., dyslipidemias) are widely known to play a key role in atherosclerosis and T2DM [38][39][40][41], mainly due to chronic inflammation, which is considered as one of the possible links between both diseases [19]. A systematic review with 57,079 participants demonstrated that patients with low fat intake had small but stable effect by reducing weight, body mass index (BMI), waist circumference, and percentage of body fat compared with those who had higher fat intake [42].…”

Section: Fatsmentioning

confidence: 99%

“…SFAs can be found in both vegetable (e.g., coconut, palm oil) and animal fats (e.g., meat, butter, and cheese). Dietary guidelines generally recommend a low-SFA diet (up to 10% of total calories) [38,39,43]. Dietary SFAs strongly raise total and low-density lipoproteins (LDL) cholesterol levels in blood.…”

Section: Fatsmentioning

confidence: 99%

Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review

et al. 2021

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Cardiovascular disease (CVD) is the most common cause of morbidity and mortality in developed countries. The prevalence of CVD is much higher in patients with type 2 diabetes mellitus (T2DM), who may benefit from lifestyle changes, which include adapted diets. In this review, we provide the role of different groups of nutrients in patients with T2DM and CVD, as well as dietary approaches that have been associated with better and worse outcomes in those patients. Many different diets and supplements have proved to be beneficial in T2DM and CVD, but further studies, guidelines, and dietary recommendations are particularly required for patients with both diseases.

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Management of Lipids in Patients with Diabetes

Cited by 10 publications

References 69 publications

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

High Glucose Promotes Epithelial-Mesenchymal Transition, Migration and Invasion in A20 Murine Diﬀuse Large B-Cell Lymphoma Cells Through Increased Expression of High Mobility Group AT-Hook 2 (HMGA2)

Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review

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