High Glucose Promotes Epithelial-Mesenchymal Transition, Migration and Invasion in A20 Murine Diﬀuse Large B-Cell Lymphoma Cells Through Increased Expression of High Mobility Group AT-Hook 2 (HMGA2)

Ya, Wang; Tan, Jie; Wu, Hongyan; Yi, Cunjian

doi:10.12659/msm.916195

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…HMGA2 involvement in EMT is very well documented in a variety of tumors, and we have discussed some of its involvement in tumor EMT and migration in connection with NCCs [146,147,[150][151][152][153][154][211][212][213][214][215][216][217][218][219]. HMGA2 is also involved in EMT of crystalline epithelial cells in lens fibrosis; this process apparently uses the same pathway of TGFβ-regulated EMT, recruiting SMAD3, HMGA2, and SNAI [220][221][222].…”

Section: Hmga In Emtmentioning

confidence: 97%

HMGA Genes and Proteins in Development and Evolution

Vignali

Marracci

2020

IJMS

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HMGA (high mobility group A) (HMGA1 and HMGA2) are small non-histone proteins that can bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors to the DNA and contributing to the overall panorama of gene expression tuning. In general, they are abundantly expressed during embryogenesis, but are downregulated in the adult differentiated tissues. In the present review, we summarize some aspects of their role during development, also dealing with relevant studies that have shed light on their functioning in cell biology and with emerging possible involvement of HMGA1 and HMGA2 in evolutionary biology.

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Section: Hmga In Emtmentioning

confidence: 97%

HMGA Genes and Proteins in Development and Evolution

Vignali

Marracci

2020

IJMS

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“…Moreover, EMT enables cells to migrate and invade in cancer 22 . EMT results in the upregulation of mesenchymal markers' expression, containing vimentin, and downregulation of key adherence proteins' expression, containing E-cadherin, which enhances the invasive and migratory properties of tumour cells 12,23 . S100 is a family of low-molecular weight proteins consisting of 25 closely related members in humans 24 .…”

Section: Discussionmentioning

confidence: 99%

Exosomes Secreted by Epidural Adipose-Derived Stem Cells Promote Malignancy and EMT in B Cell Non-Hodgkin Lymphoma by Increasing S100A4 Expression

Wang

Zhu

Zhang

et al. 2021

Preprint

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Our previous study revealed that epidural adipose-derived stem cells (ADSCs) respond to lung cancer cells and are involved in forming premetastatic niches. The biological functions of epidural ADSCs in lymphoma are still unclear. In this study, we first confirmed the B cell lymphoma-promoting effects of epidural ADSC exosomes and then compared differentially expressed genes in lymphoma cells before and after exosome treatment. In ADSC exosome-treated lymphoma cells, S100A4 expression was much higher than that in cells cultured alone. S100A4 levels had a direct relationship with EMT in cells and were also associated with the survival of lymphoma patients. Then, we tested the roles of ADSC exosomes and S100A4 in the lymphoma-promoting impacts of ADSCs. Our results showed that ADSC exosomes could foster the proliferation, EMT and invasion of lymphoma cells, as could the increase in S100A4 expression. S100A4 inhibition in two lymphoma cell lines suppressed the lymphoma cell proliferation’s ADSC exosome-mediated promotion, invasion and EMT in vitro. Moreover, S100A4 inhibition attenuated metastasis and tumour growth, and ADSC exosomes promoted tumour progression, as demonstrated in a nude mouse model of lymphoma. On the basis of these data, ADSC exosomes foster B cell lymphoma progression by increasing S100A4 expression in lymphoma cells.

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Prognostic analysis of prostaglandin D2 synthase in diffuse large B-cell lymphoma

Wang,

Xu,

et al. 2023

Holist Integ Oncol

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Purpose We aimed to analyse the correlation between prostaglandin D2 synthase (PTGDS) and a diffuse large B-cell lymphoma (DLBCL) prognosis. Methods We retrospectively collected two hundred paraffin-embedded tissue specimens that were pathologically diagnosed as DLBCL in the Fujian Tumour Hospital between January 2014 and December 2018. An abundance of paraffin-embedded tumour tissues were obtained. Twenty patients with lymphocyte-rich, benign, tissue-reactive, hypertrophic tonsillitis were selected as controls. Wax blocks were selected for primary cases and the controls were screened by professional pathologists. The levels of prostaglandin D2 synthase (PTGDS) and the EMT-related molecules, E-cadherin and vimentin, were detected by immunohistochemistry in clinical samples. A chi-square test revealed the correlations between PTGDS expression and clinicopathological characteristics, including age, sex, primary site, clinical stage, immunotyping, and International Prognostic Index (IPI) score. The Kaplan–Meier survival analysis was performed, and the diagnostic value was evaluated by receiver operating characteristic (ROC) curve analysis. Results A total of 138 cases (69%) were found to be PTGDS positive (> 30% positive cells). PTGDS staining was negative (< 30% positive cells) in 62 cases (31%). We collected the corresponding clinicopathological information and found that PTGDS expression was not significantly related to the patients’ age, tumour stage, presence of extranodal invasion, or IPI score. According to the follow-up data, patients with low PTGDS expression had poor progression-free survival (PFS) and overall survival (OS), with 2-year PFS and OS rates of 41.7% and 50%, respectively. The 2-year PFS and OS rates of PTGDS-positive patients were 89.3% and 92.9%, respectively (P < 0.0001), and the differences were significant. Conclusion We found that the expression level of PTGDS is significantly correlated with the prognosis of diffuse large B-cell lymphoma.

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High Glucose Promotes Epithelial-Mesenchymal Transition, Migration and Invasion in A20 Murine Diﬀuse Large B-Cell Lymphoma Cells Through Increased Expression of High Mobility Group AT-Hook 2 (HMGA2)

Cited by 7 publications

References 28 publications

HMGA Genes and Proteins in Development and Evolution

HMGA Genes and Proteins in Development and Evolution

Exosomes Secreted by Epidural Adipose-Derived Stem Cells Promote Malignancy and EMT in B Cell Non-Hodgkin Lymphoma by Increasing S100A4 Expression

Prognostic analysis of prostaglandin D2 synthase in diffuse large B-cell lymphoma

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