Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate

Panditray, Siddharth; Acharya, Sauvagini; Prusty, Nilamadhab; Dany, Subha S

doi:10.1007/s12070-018-1410-8

Cited by 4 publications

(6 citation statements)

References 36 publications

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“…3 Propranolol is initiated 1 mg/kg/day up to 2-3 mg/kg/day administered in 2 or 3 doses. 3 Many studies in literature have documented the effectiveness of propranolol treatment, generally in younger patients, but also for adults in a study Panditray et al 4 The success of propranolol usage in a 56-year-old patient with an hemangioma in fossa orbitalis has also been documented. 4 Moreover, timolol maleate has been shown to be an effective treatment in the proliferative phase.…”

Section: Discussionmentioning

confidence: 99%

Venous Haemangioma on Neck

İştar¹,

İLHAN²,

KÖSEOĞLU³

et al. 2022

Turkiye Klinikleri J Case Rep

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Hemangiomas are benign vascular tumors. They are categorized histologically as capillary, cavernous, and venous. Both cavernous and venous hemangiomas contain large dilated vessels. However, the vascular channels in venous hemangiomas are characterized by thick fibrous walls containing smooth muscle. On the other hand, cavernous hemangiomas consist of thin-walled vascular spaces lined by flattened endothelial cells. The extremities, head, and neck are the most usual localisations. Various treatments have been discussed in literature such as surgery, medical therapy, sclerotherapy, and cryoablation in case of pain, organ dysfunction or cosmetic reason. The case is here reported of a patient with a venous hemangioma on the neck and the treatment applied. CASE REPORTA 28-year-old female patient was admitted to the hospital due to a smooth mass on the right side of the neck. The mass had been present since childhood and started to become more obvious at the age of 13 years. Throughout the adolescent growing period, the mass continued to enlarge. During pregnancy the growth of the smooth mass accelerated reaching dimensions of 8×5 cm. The mass did not decrease in size after giving birth. The patient presented with aesthetic complaints and pain when bowing her head (Figure 1A,1B).Physical examination showed the mass to be smooth and non-pulsatile. Doppler ultrasound showed that mass was a lobulated vascular malformation. Computed tomography revealed that it contained a lobulated venous mass. There was no sign of arterio-venous fistula (Figure 1C). Informed consent was taken from the patient. Surgery was planned for both the cosmetic and pain symptoms. The patient was evaluated for cardiac pathology with echocardiography, and cranial computed tomography revealed no cerebral vascular pathology.Under general anaesthesia, a skin incision was made anterior of the m. sternocleidomastoideus. The skin and m. platisma were very thin. After wide tissue dissection, 5 thick veins related to the v. jugularis

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Section: Discussionmentioning

confidence: 99%

Venous Haemangioma on Neck

İştar¹,

İLHAN²,

KÖSEOĞLU³

et al. 2022

Turkiye Klinikleri J Case Rep

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“…These efficacy outcomes can be considered similar, with a slight advantage in favour of propranolol therapy. Both drugs showed similar safety profiles, including all side effects that occurred during the pharmacotherapy phase of the study [9].…”

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confidence: 81%

“…One group was prescribed 40 mg/day of propranolol, the other 200 mg daily of itraconazole. Sodium tetradecyl sulfate was also administered [9]. Haemangiomas were located on the tongue, palate, and various locations on the head and neck.…”

mentioning

confidence: 99%

Itraconazole as a new pharmacotherapy method in haemangiomas

Gałązka¹,

Leis²,

Mazur³

et al. 2021

pdia

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“…Treatment options include surgical excision, laser surgery, cryotherapy, chemotherapy agents, corticosteroids, embolization and sclerotherapy. 4,5 Sclerotherapy is the substitution of vascular component by a fibrotic tissue in response to an inflammatory process. 6 It is a viable option owing to its safety, ease of administration, acceptable aesthetic and functional outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…7 It counters the proliferative growth, reduces the volume of hemangioma and initializes the process of regression. 5 Some sclerosants include 3% sodium tetradecyl sulphate, 5% phenol, sodium morrhuate, nitrogen mustard, boiling water, sodium psylliate, sodium citrate, invert sugar, absolute alcohol, hypertonic saline hypertonic dextrose. 2 3% sodium tetradecyl sulphate produces endothelial damage with thrombus formation leading to fibrosis of the lesion which leads to its shrinkage.…”

Section: Introductionmentioning

confidence: 99%

Intralesional 3% sodium tetradecyl sulphate versus hot water in oral cavity hemangioma: a comparative study

Mishra

Acharya

Kar

et al. 2021

Int J Otorhinolaryngol Head Neck Surg

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Background: Oral cavity lesions fall among the few most common presentations in the outpatient department of ENT. Hemangioma in oral cavity though do not usually account for any life threatening or serious condition but hampers day to day activities like chewing, speaking and occasionally bleeding from oral cavity. Timely diagnosis and treatment solves the above problem. Though there are various modalities of treatment ranging from cryosurgery to surgical ablation, sclerotherapy is an evolving, effective and easy method for reduction of the size of lesion and preventing recurrence. It can be done as a day care procedure. The aim was to compare between the efficacy of 3% sodium tetradecyl sulphate and hot water in oral cavity hemangiomas.Methods: A total of 20 patients presenting to the OPD, department of ENT, VIMSAR, Burla, with diagnosis of hemangioma in oral cavity between January 2018 to January 2019 were selected for the study. They were divided into two groups. Group A was administered 3% sodium tetradecyl sulphate whereas group B was administered hot water, both intralesionally, at multiple sites of lesion. Injection were repeated after an interval of 2 weeks for a period of 3-4 months. The results were routinely analysed clinically and statistically and the statistical significance was set at p<0.05.Results: There was a significant improvement (p<0.05) in most of the parameters measured, in group A patients as compared to group B patients.Conclusions: 3% sodium tetradecyl sulphate is a better sclerosing agent than hot water in cases of oral cavity hemangiomas.

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Management of Head and Neck Hemangiomas in Adults: Oral Propranolol Versus Oral Itraconazole in Conjugation with Injection Sodium Tetra Decyl Sulphate

Cited by 4 publications

References 36 publications

Venous Haemangioma on Neck

Venous Haemangioma on Neck

Itraconazole as a new pharmacotherapy method in haemangiomas

Intralesional 3% sodium tetradecyl sulphate versus hot water in oral cavity hemangioma: a comparative study

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