Management of an outbreak of peste des petits ruminants with antibiotic combined hyperimmune serum therapy

Abstract

Peste des petits ruminants (PPR) is a highly contagious viral disease associated with high morbidity and mortality in goats of Bangladesh. Though there is no known effective drug against PPR virus, Animal Health Research Division (AHRD), Bangladesh Livestock Research Institute (BLRI) has developed a treatment technology “antibiotic combined hyperimmune serum therapy (ACHST)” against the deadly PPR virus. This article described the management of a huge outbreak of PPR by ACHST at goat farm of BLRI regional station, Naikhongchari, Bandarban, a hilly area of Bangladesh. Seventy two goats out of 159 goats were infected with PPR virus naturally. The clinical history and necropsy findings were recorded and nasal swabs were collected for diagnosis of PPR virus by RT-PCR. Thirty goats among 72 goats were died before providing treatment and the rest alive 42 goats were received ACHST. Each of the goats was treated with PPR specific hyperimmune serum @ 4-5ml/goat slow IV for once, Amcicoli-D (Ampicillin trihydrate, Colistin sulfate and Dexamethasone acetate) @ 1ml/10kg body weight daily IM once for 3 days and metronidazole @ 500mg/35kg body weight orally thrice daily for 3 days. After treatment, 38 goats (93.23%) were recovered out of 42 goats. The comparative evaluation of ACHST at different stages of naturally PPR infected goat’s shown highest recovery rate in incubation (100%) and prodromal (100%) phases followed by pneumonic (91.67%) and diarrhoeal (81.25%) phases. It may be concluded that the ACHST could be used as therapeutic interventions for PPR infected goats.Asian J. Med. Biol. Res. June 2015, 1(2): 230-234

Peste des petits ruminants virus infection of Black Bengal goats showed altered haematological and serum biochemical profiles

“…Veterinarians often claim to reduce the mortality of clinical PPR outbreaks to some extent with the help of supportive therapy. Moreover, a recent study shows that supportive therapy in the form of fluid and antibiotics combined with PPR-specific hyperimmune serum can reduce the mortality in PPR-infected goats (Yousuf et al 2015). However, the knowledge of haematological, serum biochemical and electrolyte profiles of clinically PPR-infected goats, which is often altered because of diarrhoea and mucopurulent discharge, is needed to better describe the disease status and formulate appropriate supportive therapy.…”

Camel viral diseases: Current diagnostic, therapeutic, and preventive strategies

“…Out of 42 goats, 38 (93.23%) recovered after receiving an antibiotic and anti-inflammatory protocol of ampicillin trihydrate, colistin sulfate, and dexamethasone acetate IM once daily for 3 days, and metronidazole 500 mg/35 kg body weight orally three times daily for 3 days ( 42 ). Long-acting tetracyclines and topical gentian violet helped resolve the PPR lesions within 3 weeks ( 43 ).…”

Prevalence of peste des petits ruminants and concurrent hematological, liver and kidney function test of Black Bengal goats reared in Jaintapur, Sylhet district in Bangladesh

“…Acute PPR usually has a poor prognosis, especially when combined with secondary bacterial infection, poor nutrition, and other stresses. To prevent secondary bacterial infection, supportive therapy with fluid, electrolytes, and antibiotics can reduce PPR mortality (Yousuf et al, 2015). To develop appropriate supportive treatment, it is necessary to understand changes in the hemato-biochemical parameters of PPR-infected goats (Das et al, 2015).…”