Malignant Lymphoma of The Canalicular: A Rare Case Report

Primary Canalicular MALT Lymphoma Masquerading as Chronic Canaliculitis

“…There are several reports of lymphoproliferative tumors involving the lacrimal sac, 1,2,4 however primary lymphoma of the canaliculus is rare, with only 1 prior report available in the literature. 3 In the prior case report the lymphoma type was not reported and the patient was lost to follow-up. Our patient was found to have extranodal marginal zone mucosa-associated lymphoid tissue lymphoma, which is the most common type of lymphoma in the ocular adnexa.…”

“…1,4 Definitive diagnosis largely relies on biopsy with histopathological evaluation. [1][2][3][4] Additional testing with orbital and systemic imaging, such as MRI or PET/CT, is useful for staging the disease. [1][2][3][4] Treatment varies depending on the severity of the disease, but includes the following: radiotherapy, observation after resection/biopsy, therapy with alkylating agents and/ or rituximab, or a combination of the prior listed treatments.…”

“…[1][2][3][4] Additional testing with orbital and systemic imaging, such as MRI or PET/CT, is useful for staging the disease. [1][2][3][4] Treatment varies depending on the severity of the disease, but includes the following: radiotherapy, observation after resection/biopsy, therapy with alkylating agents and/ or rituximab, or a combination of the prior listed treatments. [1][2][3] Despite a lack of data on the prognosis of patients with extranodal marginal zone mucosa-associated lymphoid tissue lymphoma treated only with surgical excision, this disease generally has a good prognosis overall with only 5%-10% of cases showing systemic dissemination.…”

“…[1][2][3] Despite a lack of data on the prognosis of patients with extranodal marginal zone mucosa-associated lymphoid tissue lymphoma treated only with surgical excision, this disease generally has a good prognosis overall with only 5%-10% of cases showing systemic dissemination. 2,3,6 Disease-free rates are 86.4% and 78.7% at the 5-year and 10-year mark, respectively. 7 Fortunately, our patient has done well with primary resection without adjunctive therapy and remains disease-free 12 months later.…”

“…1,2 To date, very few cases of primary canalicular lymphoma have been described in the literature. 3 The following case outlines the clinical course of a patient who was seen at a tertiary urban care center with the diagnosis of primary canalicular lymphoma. Patient consent for publication was obtained.…”