Malignancy in Perinatally Human Immunodeficiency Virus-Infected Children in the United States

Kest, Helen; Brogly, Susan B.; McSherry, George; Dashefsky, Barry; Oleske, James M.; Seage, George R.

doi:10.1097/01.inf.0000154324.59426.8d

Cited by 49 publications

(31 citation statements)

References 15 publications

(15 reference statements)

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“…This is in contrast to other reported series [6][7][8][9][10][11][12][13][14] (see Table 2), where there is a striking male predominance (male to female ratio of 9:1). The female component can be explained by the risk group for acquisition of HIV in Sowetan patients which was predominantly heterosexual, with only 1 patient exhibiting vertical transmission.…”

Section: Discussioncontrasting

confidence: 85%

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Human immunodeficiency virus infection and chronic myeloid leukemia

et al. 2012

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Section: Discussioncontrasting

confidence: 85%

“…The association is rarely described, with less than twelve reported cases in the literature [6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Human immunodeficiency virus infection and chronic myeloid leukemia

et al. 2012

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“…In 1990, an association was first made between pediatric HIV infection and an increased incidence of smooth muscle tumors [3]. Currently LMS and LM are recognized as the second most frequent type of malignancy among children with HIV, accounting for approximately 17% of cases [4,5]. Smooth muscle tumors in children with HIV have a predilection for the GI tract and lungs, sites which are rare among HIV-negative children.…”

Section: Discussionmentioning

confidence: 97%

An appendiceal leiomyoma in a child with acquired immunodeficiency syndrome

et al. 2006

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Children with acquired immunodeficiency syndrome (AIDS) are at an increased risk for lymphoproliferative and neoplastic disorders. Included among these are smooth muscle neoplasms such as leiomyomas and leiomyosarcomas. There have been at least 15 reported cases of smooth muscle tumors in the approximately 8,000 children with AIDS, however the incidence in immunocompetent children is only two per ten million. The lesions in children with human immunodeficiency virus infection are usually found in the lung, liver, and gastrointestinal tract. Here, we present an unusual case of a 12-year-old African American girl with vertically acquired AIDS who presented to the pediatric emergency department with severe diffuse abdominal pain. She was ultimately found to have an appendiceal leiomyoma on abdominal exploration, the first reported case. Our report suggests that smooth muscle tumors of the appendix be included in the differential diagnosis of abdominal masses in children with AIDS.

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“…In other study, the incidence of cancer in HIV infected children was highest in patients who received HAART less than 2 years compared to children with more than 2 years of HAART. (Kest et al, 2005) The wasting syndrome has been described in HIV infected children. The relationship between protein-energy malnutrition and adverse effects on the immune system result in immune deficiency states.…”

Section: Category C Organ-specific Diseasesmentioning

confidence: 99%

“…Leiomyosarcoma was the only soft tissue cancer to occur in HIV-infected children whereas various different soft tissues sarcomas occurred in non-infected children. (Kest et al, 2005). Lymphocitic interstitial pneumonia (LIP) is common in HIV-infected children non-treated with HAART.…”

Section: Category B Organ-specific Diseasesmentioning

confidence: 99%