Human immunodeficiency virus infection and chronic myeloid leukemia

Patel, Moosa; Philip, Vinitha; Fazel, Fatima Bibi; Lakha, Atul; Vorog, Alexander; Ali, Nazeer; Karstaedt, Alan; Pather, Sugeshni

doi:10.1016/j.leukres.2012.07.012

Cited by 18 publications

(13 citation statements)

References 23 publications

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“…To date, the literature of hematologic malignancies in South Africa is largely based on hospital‐based studies which report on patient and disease characteristics of leukemias and lymphomas , with a particular focus on the prevalence of HIV and the differences in cancer characteristics between HIV‐positive and ‐negative patients. There is a well‐established association between HIV and several types of hematologic malignancies, including but not restricted to the AIDS‐defining subtypes of NHL .…”

Section: Introductionmentioning

confidence: 99%

Hematologic malignancies in South Africa 2000–2006: analysis of data reported to the National Cancer Registry

et al. 2016

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Little is known about the incidence patterns of hematologic malignancies in Sub‐Saharan Africa, including South Africa. We estimated incidence rates of pathology‐confirmed adult cases of leukemia, myeloma and related diseases (myeloma), Hodgkin lymphoma (HL), and non‐Hodgkin lymphoma (NHL) reported to the National Cancer Registry of South Africa (NCR) between 2000 and2006, by age, gender, and population group (Black, White, Coloured, Asian/Indian). Gender‐specific age‐standardized rates were calculated overall and by population group and incidence rate ratios (IRRs) were estimated using Poisson regression models. Between 2000 and 2006, there were 14662 cases of leukemia, myeloma, HL, and NHL reported to the registry. Incidence rates of reported hematologic malignancies were generally 20–50% higher among males than females. Our analyses suggested marked differences in the rates of reported hematologic malignancies by population group which were most pronounced when comparing the White versus Black population groups (IRRs ranging from 1.6 for myeloma to 3.8 for HL for males and females combined). Challenges related to diagnosis and reporting of cancers may play a role in the patterns observed by population group while the set‐up of the NCR (pathology‐based) could lead to some degree of under‐ascertainment in all groups. This is the first country‐wide report of the incidence of hematologic malignancies in South Africa. Despite challenges, it is important to analyze and report available national cancer incidence data to raise awareness of the cancer burden and to characterize patterns by demographic characteristics so as ultimately to improve the provision of cancer‐related health care.

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Section: Introductionmentioning

confidence: 99%

Hematologic malignancies in South Africa 2000–2006: analysis of data reported to the National Cancer Registry

et al. 2016

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“…Chronic myeloid leukemia (CML) and HIV occurring in association has rarely been described [5]. Indeed, there are less than 50 reported cases in the literature, with more than half of these patients being described from sub-Saharan Africa [5,6].…”

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confidence: 99%

“…Recently, we described the largest reported series of 18 patients with HIV-CML from Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, and Johannesburg, South Africa [5]. This accounts for 7.5% of all the CML patients seen at the Clinical Hematology unit, Department of Medicine at this single centre between January 1991 and June 2011.…”

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Human Immunodeficiency Virus Infection and Chronic Myeloid Leukemia: Is there an Association?

Patel¹

2014

J Leuk

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“…Furthermore, little evidence of the use of dasatinib was found in association with ART therapy in HIV patients as a few ART treated HIV-1 patients also have CML. However, some HIV-infected patients developed CML and then started dasatinib treatment showing good dasatinib adherence and an excellent CML control (Patel et al, 2012; Campillo-Recio et al, 2014).…”

Section: Dasatinib Is Able To Inhibit Hiv Replication: Potential Use mentioning

confidence: 99%

Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection

Climent

Plana

2019

Front. Pharmacol.

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Tyrosine kinase inhibitors (TKIs) of aberrant tyrosine kinase (TK) activity have been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. An area of growing interest is the reported ability of TKIs to induce immunomodulatory effects with anti-tumor and anti-viral activity, which appears to be mediated by directly or indirectly acting on immune cells. In selected cases of patients with CML, TKI treatment may be interrupted and a non-drug remission may be observed. In these patients, an immune mechanism of increased anti-tumor cytotoxic activity induced by chronic administration of TKIs has been suggested. TKIs increase some populations of natural killer (NK), NK-LGL, and T-LGLs cells especially in dasatinib treated CML patients infected with cytomegalovirus (CMV). In addition, dasatinib increases responses against CMV and is able to inhibit HIV replication in vitro. Recent studies suggest that subclinical reactivation of CMV could drive expansion of specific subsets of NK- and T-cells with both anti-tumoral and anti-viral function. Therefore, the underlying mechanisms implicated in the expansion of this increased anti-tumor and anti-viral cytotoxic activity induced by TKIs could be a new therapeutic approach to take into account against cancer and viral infections such as HIV-1 infection. The present review will briefly summarize the immunomodulatory effects of TKIs on T cells, NKs, and B cells. Therapeutic implications for modulating immunity against cancer and viral infections and critical open questions are also discussed.

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Human immunodeficiency virus infection and chronic myeloid leukemia

Cited by 18 publications

References 23 publications

Hematologic malignancies in South Africa 2000–2006: analysis of data reported to the National Cancer Registry

Hematologic malignancies in South Africa 2000–2006: analysis of data reported to the National Cancer Registry

Human Immunodeficiency Virus Infection and Chronic Myeloid Leukemia: Is there an Association?

Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection

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