Male PCOS equivalent and nutritional restriction: Are we stepping forward?

Guardo, Federica Di; Cerana, Maria Cecilia; D’Urso, Gisella; Genovese, Fortunato; Palumbo, Marco

doi:10.1016/j.mehy.2019.03.003

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…At the moment, there is a paucity of data regarding anti-androgen therapy in women with PCOS in the context of COVID-19; hence, this is an additional aspect of the PCOS management which should be studied during this pandemic. Of note, a male PCOS equivalent syndrome has been proposed, which is characterized by early-onset androgenic alopecia in combination with one or more manifestations such as worse gonadal steroidogenesis, decreased sex hormone binding globulin (SHBG), and increased dehydroepiandrosterone sulphate (DHEAS) circulating levels, as well as insulin resistance, T2DM, obesity, and hypertension [36,37]. As such, there is a potential analogy between women with PCOS and a male PCOS equivalent syndrome that are both linked to coexisting comorbidities (e.g., T2DM, obesity, and hypertension) which, as aforementioned, predispose to severe COVID-19.…”

Section: Hyperandrogenismmentioning

confidence: 99%

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Kyrou

Karteris

Robbins

et al. 2020

BMC Med

100

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Background: In women of reproductive age, polycystic ovary syndrome (PCOS) constitutes the most frequent endocrine disorder. Women with PCOS are considered to typically belong to an age and sex group which is at lower risk for severe COVID-19. Main body: Emerging data link the risk of severe COVID-19 with certain factors such as hyper-inflammation, ethnicity predisposition, low vitamin D levels, and hyperandrogenism, all of which have known direct associations with PCOS. Moreover, in this common female patient population, there is markedly high prevalence of multiple cardio-metabolic conditions, such as type 2 diabetes, obesity, and hypertension, which may significantly increase the risk for adverse COVID-19-related outcomes. This strong overlap of risk factors for both worse PCOS cardiometabolic manifestations and severe COVID-19 should be highlighted for the clinical practice, particularly since women with PCOS often receive fragmented care from multiple healthcare services. Comprehensively informing women with PCOS regarding the potential risks from COVID-19 and how this may affect their management is also essential. Conclusion: Despite the immense challenges posed by the COVID-19 outbreak to the healthcare systems in affected countries, attention should be directed to maintain a high standard of care for complex patients such as many women with PCOS and provide relevant practical recommendations for optimal management in the setting of this fast moving pandemic.

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Section: Hyperandrogenismmentioning

confidence: 99%

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Kyrou

Karteris

Robbins

et al. 2020

BMC Med

100

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“…Some males with women relatives/siblings suffering from polycystic ovarian syndrome (PCOS) are reported to have the same hormonal, clinical, and metabolic alterations as PCOS patients which marked with higher prevalence of hyperinsulinemia, hypertriglyceridemia, hypertension, and dyslipidemia leading to cardiovascular disease and DM II. It suggests that they may inherit the genes responsible for PCOS susceptibility [11].…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance and testosterone level in Indonesian young adult males

Kurniawan

Adnan

Windarwati

et al. 2020

Romanian Journal of Internal Medicine

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AbstractIntroduction. Central obesity is characterized by the accumulation of abdominal fat which may lead to several diseases including insulin resistance. The prevalence of central obesity is higher in male and the incidence in young adult males is increased. Central obesity is also related to low testosterone levels. The research aimed to assess the relationship between the testosterone levels and insulin resistance of young adult males with central obesity.Methods. This was a cross-sectional study, the subjects were young adult males of 18 to 25 years old. The central obesity consisted of 50 samples and non-central obesity comprised 70 samples. The examination of testosterone and insulin was performed by the ECLIA method, glucose used the enzymatic method, the insulin resistance was calculated by using the HOMA-IR index.Results. The mean of the testosterone level in central obesity was lower than non-central obesity (5.24 + 1.17 vs 7.18 + 1.54 ng/mL, p < 0.001). HOMA-IR index in central obesity was higher than non-central obesity (4.29 + 2.23 vs 2.46 + 1.72, p < 0.001). Testosterone levels had negative correlation with HOMA-IR (r = –0.470, p < 0.001). There was significant difference in HOMA-IR among the quartiles of testosterone levels.Conclusion. There is negative correlation between testosterone level with HOMA-IR, the lower the testosterone level the higher the insulin resistance in young adult males.

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“…Interestingly, recent studies identified a male PCOS equivalent syndrome in males related to women with PCOS. These males present with similar metabolic, clinical, and hormonal alterations as in PCOS women, which emphasizes a strong genetic component involved in the etiology of PCOS apart from lifestyle, ethnic origin, race, and other environmental factors [4,6]. PCOS and metabolic syndrome share common metabolic and cardiovascular complications, as insulin resistance is the potential pathogenetic mechanism for both [4].…”

Section: Introductionmentioning

confidence: 91%

Significance of Homocysteine Levels in the Management of Polycystic Ovarian Syndrome: A Literature Review

Kondapaneni¹,

Gutlapalli²,

Poudel³

et al. 2020

Cureus

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Polycystic ovarian syndrome (PCOS) is a complex disorder involving cardiovascular, metabolic, endocrine, and reproductive systems. Even though the exact etiology is not clear, many studies suggest genetic and environmental factors play a role. Homocysteine (Hcy) is considered to be an independent risk factor for atherogenic and thrombotic components of various systems. Many studies in the past have evaluated Hcy levels in the PCOS population. This article aims to elaborate on the importance of Hcy levels in the overall management of PCOS. We conducted a PubMed data search using combined keywords PCOS and homocysteine levels and manually screened relevant articles for the review while avoiding duplication of data. After the literature review, we analyzed the relationship between homocysteine levels and various components of PCOS. Most of the studies identified a statistically significant elevation in Hcy levels in PCOS women with insulin resistance, androgen excess, elevated markers of cardiovascular risk, recurrent pregnancy loss, and metformin treatment. We also examined studies that focused on treating hyperhomocysteinemia (Hhcy) in PCOS women. However, because of the limited sample sizes and various inclusion criteria used for subjects in the studies, their clinical implication is unclear in routine practice. Furthermore, we encourage clinicians to follow up on Hcy levels in PCOS women at high risk for any complications in their management course. We believe an observational study on a larger scale in a welldefined PCOS population would be useful to uncover the prevalence of elevated Hcy levels in PCOS women, which would help pave the way for establishing treatment guidelines on serum Hcy levels in PCOS management.

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Male PCOS equivalent and nutritional restriction: Are we stepping forward?

Cited by 8 publications

References 43 publications

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Insulin resistance and testosterone level in Indonesian young adult males

Significance of Homocysteine Levels in the Management of Polycystic Ovarian Syndrome: A Literature Review

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