Insulin resistance and testosterone level in Indonesian young adult males

Kurniawan, Liong Boy; Adnan, Endy; Windarwati, .; Mulyono, Budi

doi:10.2478/rjim-2020-0004

Cited by 6 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study found an inverse association between pre‐diabetic and diabetic HOMA‐IR categories and both TT and SHBG concentrations in men. This result is supported by other studies with similar findings (Kurniawan et al, 2020; Quan et al, 2021; Reddy & Yadav, 2021; Ye et al, 2017). However, the relationships became non‐significant, except for the relationship between pre‐diabetic HOMA‐IR levels and SHBG, after adjustment for other variables.…”

Section: Discussionsupporting

confidence: 88%

“…The present study found a significant inverse association between insulin and both TT and SHBG, even after adjusting for other variables. This finding is consistent with several cross-sectional studies (Kurniawan et al, 2020;Leutner et al, 2022;Osuna et al, 2006;Pasquali et al, 1995;Phillips et al, 2003) and an 8-year longitudinal study (Oh et al, 2002), which found testosterone concentrations to be inversely associated with insulin concentrations over the duration of the study. Even though insulin is not a clinical condition, elevated insulin concentrations, hyperinsulinemia, may be indicative of IR and the future development of metabolic syndrome (Wilcox, 2005) (Ling et al, 2016) (Sung et al, 2011).…”

Section: Insulinsupporting

confidence: 92%

See 1 more Smart Citation

Examining the associations between testosterone and biomarkers as men age

Smith

Bekele

Lopresti

et al. 2023

American J Hum Biol

View full text Add to dashboard Cite

ObjectivesTestosterone concentrations in men decline with advancing age. However, the cause of the decline is yet to be fully elucidated. Therefore, the aims of this study were to examine the associations between chronic diseases such as obesity and type 2 diabetes mellitus (T2DM) with total testosterone (TT) and sex hormone‐binding globulin (SHBG), using a large nationally‐representative data set (National Health and Nutrition Examination Survey; NHANES).MethodsNHANES is a cross‐sectional survey, physical examination, and laboratory evaluation of a nationally‐representative sample of a non‐institutionalized United States population. Male participants aged ≥18 years during the NHANES 2013–2014 and NHANES 2015–2016 survey periods were selected for this analysis. The analysis included the following data: body mass index (BMI), oral glucose tolerance test (OGTT), homeostatic model assessment of insulin resistance (HOMA‐IR), insulin, glucose, and age.ResultsAn overweight or obese condition was significantly inversely associated with TT and SHBG, even after adjusting for other variables. Several variables associated with T2DM (OGTT, HOMA‐IR, insulin, and glucose) were also inversely associated with TT; however, only the associations between OGTT and insulin with TT remained significant after adjusting for the other variables. Insulin and HOMA‐IR levels were significantly inversely associated with SHBG; however, only the association between SHBG and pre‐diabetic HOMA‐IR levels remained significant after adjusting for the other variables. OGTT became significantly associated with SHBG after adjusting for the other variables. Age was significantly inversely associated with TT, but positively associated with SHBG, even after adjusting for other variables.ConclusionThe results of the present study, which is the largest to date, indicate that a marker of obesity, BMI, and some markers of T2DM are both independently and significantly inversely associated with TT and SHBG.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Insulinsupporting

confidence: 92%

Examining the associations between testosterone and biomarkers as men age

Smith

Bekele

Lopresti

et al. 2023

American J Hum Biol

View full text Add to dashboard Cite

show abstract

“…Testosterone is known to improve insulin sensitivity [27]. Low testosterone concentrations are associated with higher insulin resistance [28]. Even in lower normal range, they are related to a higher risk of diabetes development [29].…”

Section: Testosterone and The Insulin Sensitivitymentioning

confidence: 99%

Testosterone Deficiency as One of the Major Endocrine Disorders in Chronic Kidney Disease

et al. 2022

View full text Add to dashboard Cite

Reduced testosterone concentration is nowadays thought to be one of the main endocrine disorders in chronic kidney disease (CKD). It is caused by the dysfunction of the hypothalamic-pituitary-gonadal axis. The role of testosterone is multifactorial. Testosterone is responsible not only for reproductive processes, but it is a hormone which increases bone and muscle mass, improves lipid profile, insulin sensitivity, erythropoiesis, reduces blood pressure, and ameliorates mood and perception. The implications of hypogonadism in CKD are infertility and loss of libido, reduction of muscle mass and strength, disorders in bone mineralization, the development of sarcopenia and protein energy wasting (PEW), progression of atherosclerosis, increased visceral adiposity, insulin resistance, and anaemia. Reduced testosterone serum concentrations in CKD are associated with increased mortality rate. Testosterone supplementation improves sexual functions, reduces the level of inflammatory markers and blood pressure, stimulates muscle protein synthesis, improves insulin sensitivity and lipid profile, and increases muscle mass, bone mineral density, and haemoglobin concentration. It positively affects mood and well-being. The modes of testosterone supplementation are intramuscular injections, subcutaneous pellets, and percutaneous methods—patches and gels. Successful kidney transplantation may improve gonadal function and testosterone production, however, half of men with low testosterone concentrations before kidney transplantation do not restore hormonal function.

show abstract

“…Cellular alterations caused by obesity, such as oxidative stress, inflammation, and DNA damage accumulation are the potential driving factors for the aging process (20). Epidemiologic studies show that obese men have lower testosterone compared to lean men in diverse ethnic population (21)(22)(23)(24). Recent studies suggest that obesity is related to age-related decline in testosterone.…”

Section: Introductionmentioning

confidence: 99%

Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone

Luo

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

IntroductionAge-related decline in testosterone is associated with Leydig cell aging with impaired testosterone synthesis in aging. Obesity accelerates the age-related decline in testosterone. However, the mechanisms underlying the Leydig cell aging and the effects of obesity on Leydig cell aging remain unclear.MethodNatural aging mice and diet-induced obese mice were used to assess the process of testicular Leydig cell senescence with age or obesity. Bioinformatic analysis of the young and aged human testes was used to explore key genes related Leydig cell aging. Leydig cell-specific p38 MAPK knockout (p38LCKO) mice were used to further analyze the roles of p38 MAPK in Leydig cell aging. The levels of testosterone and steroidogenic enzymes, activity of p38 MAPK, aging status of Leydig cells, and oxidative stress and inflammation of testes or Leydig cells were detected by ELISA, immunoblotting, immunofluorescence, and senescence-associated β-galactosidase (SA-β-Gal) staining analysis, respectively.ResultThe serum testosterone level was significantly reduced in aged mice compared with young mice. In the testis of aged mice, the reduced mRNA and protein levels of LHCGR, SRB1, StAR, CYP11A1, and CYP17A1 and the elevated oxidative stress and inflammation were observed. KEGG analysis showed that MAPK pathway was changed in aged Leydig cells, and immunoblotting displayed that p38 MAPK was activated in aged Leydig cells. The intensity of SA-β-Gal staining on Leydig cells and the number of p21-postive Leydig cells in aged mice were more than those of young mice. Similar to aged mice, the testosterone-related indexes decreased, and the age-related indexes increased in the testicular Leydig cells of high fat diet (HFD) mice. Aged p38LCKO mice had higher levels of testosterone and steroidogenic enzymes than those of age-matched wild-type (WT) littermates, with reduced the intensity of SA-β-Gal staining and the expression of p21 protein.ConclusionOur study suggested that obesity was an important risk factor for Leydig cell aging. p38 MAPK was involved in Leydig cell aging induced by age and obesity. The inhibition of p38 MAPK could delay Leydig cell aging and alleviate decline in testosterone.

show abstract

Insulin resistance and testosterone level in Indonesian young adult males

Cited by 6 publications

References 19 publications

Examining the associations between testosterone and biomarkers as men age

Examining the associations between testosterone and biomarkers as men age

Testosterone Deficiency as One of the Major Endocrine Disorders in Chronic Kidney Disease

Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone

Contact Info

Product

Resources

About