Malaria in gold coast students on their return from the United Kingdom

Colbourne, M. J.

doi:10.1016/0035-9203(55)90017-1

Cited by 10 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding that urban Senegalese display a lower pro‐inflammatory profile compared with rural subjects suggests that immunological changes might be associated with a break from traditional lifestyle and lower exposure to infections. This is supported by the reports of changes in immunological profiles of African migrants in Europe after several years . More recently, Smolen et al .…”

Section: Discussionsupporting

confidence: 62%

“…In addition to the cytokine profiles and activation status, we also investigated the memory phenotypes showing that Senegalese people, especially rural subjects, display more CD45RO + memory CD4 + T cells and CD27 + B cells compared with the Dutch group. This higher level of memory cells in rural subjects is in line with the finding that environment impacts on the immune system . Next to the total memory phenotype, we also defined CD45RO + CD27 + central memory CD4 + T cells and CD45RO + CD27 − effector memory CD4 + T cells as in the study of Kovacs et al .…”

Section: Discussionsupporting

confidence: 57%

“…This is supported by the reports of changes in immunological profiles of African migrants in Europe after several years. 37,38 More recently, Smolen et al 39 have shown, in 2-year-old infants, that cytokine and chemokine production in response to pattern recognition receptor ligands were lower in South African infants compared with Europeans, North Americans and South American infants. In terms of immune responsiveness between low (in Africa) and high (in Europe) income countries, our results are different as we report, if any, a higher immunological response in Senegalese.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Changes in immunological profile as a function of urbanization and lifestyle

et al. 2014

View full text Add to dashboard Cite

Summary Differences in lifestyle and break with natural environment appear to be associated with changes in the immune system resulting in various adverse health effects. Although genetics can have a major impact on the immune system and disease susceptibility, the contribution of environmental factors is thought to be substantial. Here, we investigated the immunological profile of healthy volunteers living in a rural and an urban area of a developing African country (Senegal), and in a European country (the Netherlands). Using flow cytometry, we investigated T helper type 1 (Th1), Th2, Th17, Th22 and regulatory T cells, as well as CD4+ T‐cell and B‐cell activation markers, and subsets of memory T and B cells in the peripheral blood. Rural Senegalese had significantly higher frequencies of Th1, Th2 and Th22 cells, memory CD4+ T and B cells, as well as activated CD4+ T and B cells compared with urban Senegalese and urban Dutch people. Within the Senegalese population, rural paritcipants displayed significantly higher frequencies of Th2 and Th22 cells, as well as higher pro‐inflammatory and T‐cell activation and memory profiles compared with the urban population. The greater magnitude of immune activation and the enlarged memory pool, together with Th2 polarization, seen in rural participants from Africa, followed by urban Africans and Europeans suggest that environmental changes may define immunological footprints, which could have consequences for disease patterns in general and vaccine responses in particular.

show abstract

Section: Discussionsupporting

confidence: 62%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in immunological profile as a function of urbanization and lifestyle

et al. 2014

View full text Add to dashboard Cite

show abstract

“…To this latter point, anecdotal evidence is sometimes invoked to suggest that protective immunity is short-lived and requires ongoing parasite exposure and presumably occasional subclinical parasitosis. Although generally believed to wane within months to a few years of nonexposure, naturally acquired protection against severe malaria may persist for many years despite lack of parasite exposure (11,22,64,99).…”

Section: Immunologymentioning

confidence: 99%

Approaches to Malaria Vaccine Development Using the Retrospectroscope

Sardá

Kaslow

2009

Infect Immun

View full text Add to dashboard Cite

“…Although many people who grew up in countries where malaria is endemic believe themselves to be immune, 7,8 immunity begins to wane within 6 months of departure from the endemic area in the absence of re-exposure. [9][10][11] Thus, malaria should be included in the differential diagnosis of fever for people who were born in or previously lived in areas where malaria is endemic.…”

mentioning

confidence: 99%