Approaches to Malaria Vaccine Development Using the Retrospectroscope

Sardá, Vanessa; Kaslow, David C.

doi:10.1128/iai.00122-09

Cited by 7 publications

(5 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, Southeast Asia has in the last decades been the cradle for the emergence of P. falciparum resistance to chloroquine (Eyles et al 1963;Young et al 1963), sulfadoxine -pyrimethamine (Hofler 1980;Hurwitz et al 1981), mefloquine (Boudreau et al 1982;Smithuis et al 1993), and more recently to artemisinins (Noedl et al 2008;Dondorp et al 2009) and piperaquine (Leang et al 2013;Saunders et al 2014). An important reason for this apparent brake on resistance emergence in regions with high stable transmission is host immunity, which can contribute substantially to parasite clearance of partial resistant parasite and also makes that older children and adults can carry substantial numbers of parasites without causing illness (Sarda et al 2009;Lopera-Mesa et al 2013). Because these individuals will not seek treatment, the associated large asymptomatic reservoir dilutes the selective pressure provided by antimalarial drugs at the population level (White 2004).…”

Section: Origins Of Antimalarial Drug Resistancementioning

confidence: 99%

Antimalarial Drug Resistance: A Threat to Malaria Elimination

Ménard¹,

Dondorp²

2017

Cold Spring Harb Perspect Med

377

339

View full text Add to dashboard Cite

Section: Origins Of Antimalarial Drug Resistancementioning

confidence: 99%

Antimalarial Drug Resistance: A Threat to Malaria Elimination

Ménard¹,

Dondorp²

2017

Cold Spring Harb Perspect Med

377

339

View full text Add to dashboard Cite

“…These data should also be discussed in the context of administering analgesics during the challenge phase of vaccine studies. There are several examples where the potency of vaccines is increased because the challenge organism results in unapparent or subclinical infections, but ultimately results in a vaccine booster [124][125][126][127]. This was demonstrated in studies with the human anthrax vaccine [125].…”

Section: Discussionmentioning

confidence: 98%

The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice

et al. 2019

View full text Add to dashboard Cite

The administration of antipyretic analgesics prior to, in conjunction with, or due to sequelae associated with vaccination is a common yet somewhat controversial practice. In the context of human vaccination, it is unclear if even short-term analgesic regimens can significantly alter the resulting immune response, as literature exists to support several scenarios including substantial immune interference. In this report, we used a live attenuated Yersinia pestis vaccine to examine the impact of analgesic administration on the immune response elicited by a single dose of a live bacterial vaccine in mice. Mice were assessed by evaluating natural and provoked behavior, as well as food and water consumption. The resulting immune responses were assessed by determining antibody titers against multiple antigens and assaying cellular responses in stimulated splenocytes collected from vaccinated animals. We observed no substantial benefit to the mice associated with the analgesic administration. Splenocytes from both C57BL/6 and BALB/c vaccinated mice receiving acetaminophen have a significantly reduced interferon-gamma (IFN-γ) recall response. Additionally, there is a significantly lower immunoglobulin (Ig)G2a/IgG1 ratio in vaccinated BALB/c mice treated with either acetaminophen or meloxicam and a significantly lower IgG2c/IgG1 ratio in vaccinated C57BL/6 mice treated with acetaminophen. Taken together, our data indicate that the use of analgesics, while possibly ethically warranted, may hinder the accurate characterization and evaluation of novel vaccine strategies with little to no appreciable benefits to the vaccinated mice.

show abstract

“…Because the parasite endures a significant numerical bottleneck as it is transmitted between hosts, it is thought the parasite is most vulnerable to immune attack as it cycles between the definitive and intermediate hosts [7]. That protective immunity able to block transmission of the parasite as it passes through these numerical bottlenecks is never acquired [8], despite repeated infections, provides an opportunity to induce novel immune responses through active immunization [9].…”

Section: Circumsporozoite Protein and Rtssmentioning

confidence: 99%

RTS,S: Toward a first landmark on the Malaria Vaccine Technology Roadmap

Kaslow

Biernaux

2015

Vaccine

Self Cite

View full text Add to dashboard Cite

The Malaria Vaccine Technology Roadmap calls for a 2015 landmark goal of a first-generation malaria vaccine that has protective efficacy against severe disease and death, lasting longer than one year. This review focuses on product development efforts over the last five years of RTS,S, a pre-erythrocytic, recombinant subunit, adjuvanted, candidate malaria vaccine designed with this goal of a first-generation malaria vaccine in mind. RTS,S recently completed a successful pivotal Phase III safety, efficacy and immunogenicity study. Although vaccine efficacy was found to be modest, a substantial number of cases of clinical malaria were averted over a 3-4 years period, particularly in settings of significant disease burden. European regulators have subsequently adopted a positive opinion under the Article 58 procedure for an indication of active immunization of children aged 6 weeks up to 17 months against malaria caused by Plasmodium falciparum and against hepatitis B. Further evaluations of the benefit, risk, feasibility and cost-effectiveness of RTS,S are now anticipated through policy and financing reviews at the global and national levels.

show abstract

Approaches to Malaria Vaccine Development Using the Retrospectroscope

Cited by 7 publications

References 109 publications

Antimalarial Drug Resistance: A Threat to Malaria Elimination

Antimalarial Drug Resistance: A Threat to Malaria Elimination

The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice

RTS,S: Toward a first landmark on the Malaria Vaccine Technology Roadmap

Contact Info

Product

Resources

About