Magnetic resonance imaging determinants of intraindividual variability in the elderly: combined analysis of grey and white matter

Moy, G.; Millet, Philippe; Haller, Sven; Baudois, Sandra; Bilbao, Fabienne de; Weber, Kerstin; Lövblad, Karl-Olof; Lazeyras, François; Giannakopoulos, Pantéleimon; Delaloye, Christophe

doi:10.1016/j.neuroscience.2011.04.028

Cited by 42 publications

(41 citation statements)

References 35 publications

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“…Furthermore, negative relationships between IIV and total WM volume and WM volume in frontal, parietal, and temporal regions (Ullen et al, 2008) have been reported. Recently, Moy et al (2011) tested for associations with both gray matter density and WM integrity in 61 adults aged 22-88 years. Only FA showed an age-independent relationship with IIV, with negative relationships in the splenium of the CC and in the left inferior fronto-occipital fasciculus.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, two recent diffusion tensor imaging (DTI) studies (Fjell et al, 2011;Moy et al, 2011) found relationships between performance variability and the quality of WM and that the strength of these associations increased in older adults. DTI is a neuroimaging technique that is sensitive to the self-diffusion of water molecules and provides quantitative measures of WM microstructural integrity and connectivity (Basser and Jones, 2002;Beaulieu, 2002;Le Bihan, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Becoming Consistent: Developmental Reductions in Intraindividual Variability in Reaction Time Are Related to White Matter Integrity

Tamnes

Fjell²,

Westlye³

et al. 2012

J. Neurosci.

180

177

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Cognitive development is known to involve improvements in accuracy, capacity, and processing speed. Less is known about the role of performance consistency, and there has been virtually no empirical examination of the neural underpinnings of within-person variability in development. In a sample of 92 healthy children and adolescents aged 8 -19 years, we aimed to characterize age-related changes in trial-to-trial intraindividual variability (IIV) of reaction time (RT) and to test whether IIV is related to white matter (WM) integrity as indexed by diffusion tensor imaging. IIV was quantified as the SD of correct RTs in a speeded arrow flanker task, and Tract-Based Spatial Statistics was used to test relationships with diffusion characteristics. Large age-related reductions in IIV in both simple congruent trials and more complex incongruent trials were found. Independently of sex, age, and median RT (mRT), lower IIV was associated with higher fractional anisotropy and lower overall diffusivity. Effects were seen for IIV in one or both trial types in the corticospinal tract, the left superior longitudinal fasciculus, the uncinate fasciculus, the forceps minor, and in the genu and splenium of the corpus callosum. There were no significant associations between mRT and any of the diffusion indices. The findings support the proposition that developmental reductions in IIV reflect maturation of WM connectivity and highlight the importance of considering within-person variability in theories of cognitive development and its neurobiological foundation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Becoming Consistent: Developmental Reductions in Intraindividual Variability in Reaction Time Are Related to White Matter Integrity

Tamnes

Fjell²,

Westlye³

et al. 2012

J. Neurosci.

180

177

View full text Add to dashboard Cite

show abstract

“…WM changes, including volumetric decline, demyelination, hyperintensities, and FA, have been related to increased performance variability in previous studies (Britton et al, 1991;Anstey et al, 2007;Bunce et al, 2007;Walhovd and Fjell, 2007;Ullén et al, 2008;Moy et al, 2011). A recent DTI study yielded inconclusive results in that FA, but not other diffusion parameters, correlated with IIV (Moy et al, 2011). However, mean RT was not controlled for, and thus it is uncertain whether the effect could be explained by increased IIV as a function of increased RT.…”

Section: Wm Characteristics and Iivmentioning

confidence: 99%

Reduced White Matter Integrity Is Related to Cognitive Instability

Fjell

Westlye²,

Amlien³

et al. 2011

J. Neurosci.

121

106

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Increased performance variability has been demonstrated in several groups and conditions, including aging and cognitive decline. Structural brain characteristics underlying this phenomenon have so far been elusive. However, there is reason to expect that disconnectivity in associative pathways, whether caused by immature or degraded white matter (WM) tracts, will increase performance variability by neural noise. The aim of this study was to test whether the quality of WM, measured by diffusion tensor imaging, is related to performance variability in healthy adults. Intraindividual standard deviation of the reaction time (sdRT) across trials and median reaction time (mRT) from 270 participants were obtained from a speeded continuous performance task (Eriksen flanker task) with two conditions (congruent, incongruent). Tract-based spatial statistics was used to test the relationship with diffusion characteristics [fractional anisotropy (FA), mean diffusion (MD), radial diffusion (RD), axial diffusion (AD)]. Robust relationships between sdRT and all diffusion measures were found in most WM areas, independently of mRT, age, and sex. The effects were anatomically more widespread in the congruent than the incongruent condition, covering almost 50% of the voxels for RD and MD, and Ͼ25% of the voxels for FA and AD. Partial betas were in the range 0.45-0.55, and the strength of the relationships increased significantly with age. For mRT, the effects were smaller and unstable across condition. We concluded that performance variability is a likely consequence of individual differences in WM integrity, and that it is a promising behavioral correlate of individual differences in WM microstructure.

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“…Second, we did not find any significant correlations between cognitive tests (including processing speed, attention, working memory and executive function tests) and neuroimaging data (including grey matter and mean diffusivity VBA and fractional anisotropy TBSS) within a group of 16 young healthy controls between the ages of 20 and 34 years in a subset of data from among our previous studies. 42 Finally, a detailed history of cannabis use (including duration and quantity of consumption) for our patients was missing.…”

Section: Limitationsmentioning

confidence: 99%

Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter

Ruef

Curtis

Moy

et al. 2012

J Psychiatry Neurosci

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Magnetic resonance imaging determinants of intraindividual variability in the elderly: combined analysis of grey and white matter

Cited by 42 publications

References 35 publications

Becoming Consistent: Developmental Reductions in Intraindividual Variability in Reaction Time Are Related to White Matter Integrity

Becoming Consistent: Developmental Reductions in Intraindividual Variability in Reaction Time Are Related to White Matter Integrity

Reduced White Matter Integrity Is Related to Cognitive Instability

Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter

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