Magnetic Nanomaterials for Magnetically-Aided Drug Delivery and Hyperthermia

Kalubowilage, Madumali; Janik, Katharine; Bossmann, Stefan H.

doi:10.3390/app9142927

Cited by 29 publications

(15 citation statements)

References 101 publications

(152 reference statements)

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“…This is because of its properties such as nanosize, crystallinity, large specific surface area, superparamagnetism and magnetization value [ 1 ]. Fe 3 O 4 have been studied for many technological applications including magnetic resonance imaging, ferrofluids for audio speakers, magnetic recording media, magnetic targeted drug delivery, magnetic hyperthermia, separation and removal of contaminants [ 1 , 2 ] and nucleic acid separation [ 3 ]. However, the pristine magnetic nanoparticles are chemically active, and can easily oxidize in air to other forms leading to loss in magnetic properties and dispersibility.…”

Section: Introductionmentioning

confidence: 99%

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

et al. 2021

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Nanocomposite film of poly(vinyl alcohol) (PVA) incorporated with bacterial cellulose nanocrystals (BCNCs) and magnetite nanoparticles (Fe3O4) is reported in this study. The BCNC-Fe3O4 nanoparticles and PVA film was prepared by in situ synthesis technique using chemical co-precipitation. Different concentrations of BCNC-Fe3O4 (20%, 40% and 60% w/w) were mechanically dispersed in PVA solution to form the nanocomposite film. Transmission electron microscopy (TEM) analysis of BCNC-Fe3O4 nanoparticles showed irregular particle sizes ranging from 4.93 to 30.44 nm with an average size distribution of 22.94 nm. The presence of characteristic functional groups of PVA, BCNC and Fe3O4 were confirmed by Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis. Scanning electron microscope (SEM) attached energy dispersive spectroscopy (EDS) and vibrating sample magnetometer (VSM) analysis revealed that, the iron content and magnetic property increased with increasing BCNC-Fe3O4 content. The saturation magnetizations (MS) value increased from 5.14 to 11.56 emu/g. The PVA/ BCNC-Fe3O4 at 60% showed the highest Young’s modulus value of 2.35 ± 0.16 GPa. The prepared film could be a promising polymeric nanomaterial for various magnetic-based applications and for the design of smart electronic devices.

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Section: Introductionmentioning

confidence: 99%

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

et al. 2021

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“…184 Since magnetic nanoparticles are drawn to a high magnetic flux density, magnets can manipulate magnet-labeled cells; this has been implemented in tissue engineering. 185 The magnetic chitosan nanoparticles are promising materials for numerous biomedical applications, 186 including target drug delivery and imaging, 187 hyperthermia, 188 stem cell tracking, 189 tracking and magnet sequencing such as fast DNA sequence. 190…”

Section: Application Of Magnetic Chitosan In the Biomedical Industrymentioning

confidence: 99%

Preparation and application of magnetic chitosan in environmental remediation and other fields: A review

Shaumbwa

Liu

Archer

et al. 2021

J of Applied Polymer Sci

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Magnetic chitosan has received considerable attention over the decades due to its low cost, biodegradability, green sources, magnetic intensity. In this review, we reviewed the preparation methods of magnetic chitosan using co-precipitation, cross-linking and electrochemical. Therein cross-linking methodologies involved in the reaction of amino groups are facile to introduce additional reaction groups and improve anti-swelling of chitosan layers, mostly in an acidic environment. Besides, we focused on the applications of magnetic chitosan in various fields such as wastewater treatment, for example, removal of heavy metal ions, organic/inorganic dyes, fluorides, and pesticides. Moreover, magnetic chitosan also reveals great potential application in the field of medical, pharmaceutical, food and electronic screening. Above all, magnetic chitosan is economically and operationally beneficial as it can be easily separated and controlled with an external magnetic field and can be modified to maximize its functions.

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“…The treatment of cancer in 30 patients out of 32 remained successful. [51] • Another attempt was made in 2004 to check the effectiveness of magnetically aiming in the treatment of hepatic carcinomas of four patients. DOX paired with magnetostrictive vehicles was delivered through the hepatic arteries in this study using concurrent magnetic resonant scanning.…”

Section: The Evolution Of Magnetic Drug Deliverymentioning

confidence: 99%

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

Aslam

Shukrullah

Naz

et al. 2021

Part & Part Syst Charact

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encountering non-target tissues, cells, or areas. [2] An overview of the general drug delivery system is given in Figure 1. Over four decades ago, the idea of "magnetized medication delivery" was proposed as a highly potential use of magnetic nanoparticles. Magnetic nanostructures are granules comprising of polymeric materials and medicine together with ferromagnetic components (magnetite). Substances utilized in the creation of nanostructures are sterilizable, harmless, and disposable; good examples include gelatin, ethyl cellulose, albumin, and collagen. [3] The idea of magnetostrictive aiming begins with linking active ingredients to magnetic nanocrystals accompanied by the infusion and assistance of these molecules to a target tissue under the impact of regionalized strong magnetic field and keeping there at site till the completion of the treatment and ultimate disposal. Literature shows six kinds of magnetic substances, i.e., antiferromagnetic, ferromagnetic, superparamagnetic, ferromagnetic, paramagnetic and diamagnetic. [4] The detail of these substances is given in Table 1. Once the external field is withdrawn, paramagnetic components shed magnetic momentum and super-paramagnetic substances turn nonmagnetic, unless an additional field is applied. [5] Nanomaterials may transport huge dosages of medicines to obtain great localized accumulation, preventing cytotoxic and other undesirable side symptoms occurring due to excessive dosing frequency in other regions of the body. In situ investigations showed that real clinical studies are a difficult job due to length management, durability, cytocompatibility, and adhesive coating for drug action as well as other physiologic characteristics. [3,6,7] The details of possible uses of magnetic nanoparticles (MNPs) in biomedical applications are given in Figure 2.The aim of creating or even strengthening administration methods is to deliver medicines to specific areas of the patient's system via a channel that can regulate the therapeutic distribution in terms of a physiologic or biochemical stimulus. Synthetic polymer-based microcapsules, microemulsions, and micelles are reported to be efficient in improving drug selectivity, reducing therapeutic toxicity, enhancing clinical oral bioavailability, and safety of medical products against biological degeneration. [15,16] Magnetically guided drug transportation is a technique in which magnetic pharmaceutical transporters in organisms are controlled by applied magnetic forces to deliver drugs to the desired location. Different magnetic drug delivery systems (MDDSs) are developed to treat a variety of illnesses, particularly cancer and neurological disorders. However, a unique magnetic setup is required in each application for an effective magnetically guided drug aiming to direct the drug-carrying nanocarriers to the intended area. The current and future perspectives of MDDS are investigated in this study by considering their biological functions, deliverable efficiency, complexity, and the nature of the externally applie...

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Magnetic Nanomaterials for Magnetically-Aided Drug Delivery and Hyperthermia

Cited by 29 publications

References 101 publications

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

Preparation and application of magnetic chitosan in environmental remediation and other fields: A review

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

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