Magnetic bioactive glasses/Cisplatin loaded-chitosan (CS)-grafted- poly (ε-caprolactone) nanofibers against bone cancer treatment

Amini, Zahra; Rudsary, Sam Shekofte; Shahraeini, Seyed Sadegh; Dizaji, Babak Faraji; Goleij, Pouya; Bakhtiari, Ameneh; Irani, Mohammad; Sharifianjazi, Fariborz

doi:10.1016/j.carbpol.2021.117680

Cited by 36 publications

(19 citation statements)

References 55 publications

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“…For instance, Sharifianjazi et al synthesized the composite nanofibers of CS-g-PCL/MBGs and CS-g-PCL/MBGs/Cisplatin in which BGs nanoparticles were prepared using a sol-gel procedure through the molar-ratio chemical composite of 65 SiO 2 -4P 2 O 5 -31CaO. They introduced different values of MBGs and MBGs/Cisplatin (10, and 20 wt.% according to the weight of copolymer) into the solution of CS-g-PCL using further 6 h stirring [ 111 ]. Furthermore, in another work, 3D porous nanocomposite scaffolds were fabricated by chitosan, polylactic acid, and calcium phosphate powders, which were synthesized through the freeze-casting procedure.…”

Section: Synthesis Techniques Of Chitosan Compositesmentioning

confidence: 99%

Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review

et al. 2022

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Chitosan is a biopolymer that is found in nature and is produced from chitin deacetylation. Chitosan has been studied thoroughly for multiple applications with an interdisciplinary approach. Antifungal antibacterial activities, mucoadhesion, non-toxicity, biodegradability, and biocompatibility are some of the unique characteristics of chitosan-based biomaterials. Moreover, chitosan is the only widely-used natural polysaccharide, and it is possible to chemically modify it for different applications and functions. In various fields, chitosan composite and compound manufacturing has acquired much interest in developing several promising products. Chitosan and its derivatives have gained attention universally in biomedical and pharmaceutical industries as a result of their desired characteristics. In the present mini-review, novel methods for preparing chitosan-containing materials for dental and implant engineering applications along with challenges and future perspectives are discussed.

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Section: Synthesis Techniques Of Chitosan Compositesmentioning

confidence: 99%

Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review

et al. 2022

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“…Drug release on demand from a fiber-shaped delivery system was triggered in response to varying pH and temperatures [126]. In such a case, magnetic bioactive glasses complexed with the antitumor drug Cisplatin were doped into the chitosan-grafted poly(εcaprolactone) (PCL) nanofibers.…”

Section: Magnetic Fibersmentioning

confidence: 99%

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

et al. 2022

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Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.

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“…The amino and hydroxyl groups are the points of initiation of the graft copolymerization [ 259 ]. The biodegradable polymers that have been copolymerized with CS are very varied, and the most studied include PLA, polycaprolactone (PCL) [ 260 ], lignocellulosic products, pectin [ 132 ], gelatin [ 261 , 262 , 263 ], silk proteins [ 264 , 265 ], and peptides [ 266 , 267 ]. Cui et al grafted CS on electrospun PLA nanofibers to induce the deposition and growth of HA crystals [ 268 ].…”

Section: Application Of Chitosan Grafted With Biodegradable Polymers ...mentioning

confidence: 99%

Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

Zhu

Zhang

Zhou

2022

IJMS

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In recent years, bone tissue engineering (BTE), as a multidisciplinary field, has shown considerable promise in replacing traditional treatment modalities (i.e., autografts, allografts, and xenografts). Since bone is such a complex and dynamic structure, the construction of bone tissue composite materials has become an attractive strategy to guide bone growth and regeneration. Chitosan and its derivatives have been promising vehicles for BTE owing to their unique physical and chemical properties. With intrinsic physicochemical characteristics and closeness to the extracellular matrix of bones, chitosan-based composite scaffolds have been proved to be a promising candidate for providing successful bone regeneration and defect repair capacity. Advances in chitosan-based scaffolds for BTE have produced efficient and efficacious bio-properties via material structural design and different modifications. Efforts have been put into the modification of chitosan to overcome its limitations, including insolubility in water, faster depolymerization in the body, and blood incompatibility. Herein, we discuss the various modification methods of chitosan that expand its fields of application, which would pave the way for future applied research in biomedical innovation and regenerative medicine.

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Magnetic bioactive glasses/Cisplatin loaded-chitosan (CS)-grafted- poly (ε-caprolactone) nanofibers against bone cancer treatment

Cited by 36 publications

References 55 publications

Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review

Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

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