Machine Learning Analysis of the Relationships Between Gray Matter Volume and Childhood Trauma in a Transdiagnostic Community-Based Sample

Clausen, Ashley; Aupperle, Robin L.; Waller, Darcy A.; Payne, Janelle; Kuplicki, Rayus; Akeman, Elisabeth; Paulus, Martin P.; Bodurka, Jerzy; Simmons, Kyle; Feinstein, Justin S.; Savitz, Jonathan; Cha, Yoon‐Hee; Khalsa, Sahib S.; Victor, Teresa A.

doi:10.1016/j.bpsc.2019.03.001

Cited by 19 publications

(23 citation statements)

References 52 publications

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“…All participants provided written informed consent before they completed the study protocol, in accordance with the Declaration of Helsinki, and they were compensated for participation (ClinicalTrials.gov identifier NCT02450240). A number of previous papers have been published from the larger T1000 data set, [36][37][38][39][40][41][42][43][44][45][46] but none of these papers has included analyses or data from the AAC task.…”

Section: Participantsmentioning

confidence: 99%

Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach

Smith

Kirlić

Stewart

et al. 2021

jpn

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Background: Imbalances in approach-avoidance conflict (AAC) decision-making (e.g., sacrificing rewards to avoid negative outcomes) are considered central to multiple psychiatric disorders. We used computational modelling to examine 2 factors that are often not distinguished in descriptive analyses of AAC: decision uncertainty and sensitivity to negative outcomes versus rewards (emotional conflict). Methods: A previously validated AAC task was completed by 478 participants, including healthy controls (n = 59), people with substance use disorders (n = 159) and people with depression and/or anxiety disorders who did not have substance use disorders (n = 260). Using an active inference model, we estimated individual-level values for a model parameter that reflected decision uncertainty and another that reflected emotional conflict. We also repeated analyses in a subsample (59 healthy controls, 161 people with depression and/or anxiety disorders, 56 people with substance use disorders) that was propensity-matched for age and general intelligence. Results: The model showed high accuracy (72%). As further validation, parameters correlated with reaction times and self-reported task motivations in expected directions. The emotional conflict parameter further correlated with self-reported anxiety during the task (r = 0.32, p < 0.001), and the decision uncertainty parameter correlated with self-reported difficulty making decisions (r = 0.45, p < 0.001). Compared to healthy controls, people with depression and/or anxiety disorders and people with substance use disorders showed higher decision uncertainty in the propensity-matched sample (t = 2.16, p = 0.03, and t = 2.88, p = 0.005, respectively), with analogous results in the full sample; people with substance use disorders also showed lower emotional conflict in the full sample (t = 3.17, p = 0.002). Limitations: This study was limited by heterogeneity of the clinical sample and an inability to examine learning. Conclusion: These results suggest that reduced confidence in how to act, rather than increased emotional conflict, may explain maladaptive approach-avoidance behaviours in people with psychiatric disorders.

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Section: Participantsmentioning

confidence: 99%

Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach

Smith

Kirlić

Stewart

et al. 2021

jpn

Self Cite

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“…Cortical thinning of the OFC has been associated with maltreatment in children (Kelly et al., 2013), and reduced OFC thickness has been reported in adolescents who experienced childhood abuse (Gold et al., 2016). Relatedly, reduced volume of the OFC measured during adulthood has been associated with childhood adversity (Clausen et al., 2019; Dannlowski et al., 2012). Consistent with these individual findings, a voxel-wise meta-analysis of data from 693 children, adolescents, and adults found evidence of reduced OFC volume as a function of childhood maltreatment (Lim et al., 2014).…”

Section: Discussionmentioning

confidence: 99%

Corticolimbic circuit structure moderates an association between early life stress and later trait anxiety

Kim

Farber

Knodt

et al. 2019

NeuroImage: Clinical

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Each participant was scanned using one of the two identical research-dedicated GE MR750 3T scanner equipped with high-power high-duty-cycle 50-mT/m gradients at 200 T/m/s slew rate, and an eight-channel head coil for parallel imaging at high bandwidth up to 1 MHz at the Duke-UNC Brain Imaging and Analysis Center. For dMRI data, following an ASSET calibration scan, diffusion-weighted images were acquired across two consecutive 2-min 50-s providing full brain coverage with 2 mm isotropic resolution and 15 diffusion-weighted directions (echo time (TE) = 84.9 ms, repetition time (TR) = 10,000 ms, b value = 1,000 s/mm 2 , field of view (FOV) = 240 mm, flip angle = 90°, matrix = 128 × 128, slice thickness = 2 mm). For fMRI data, first a semi-automated high-ordershimming program was used to ensure global field homogeneity. A series of 34 interleaved axial functional slices aligned with the anterior commissure-posterior commissure plane were acquired for full-brain coverage using an inverse-spiral pulse sequence to reduce susceptibility artifacts (TR/TE/flip angle=2000 ms/30 ms/60; FOV=240mm; 3.75×3.75×4mm voxels; interslice skip=0). Four initial radiofrequency excitations were performed (and discarded) to achieve steady-state equilibrium. To allow for spatial registration of each participant's data to a standard coordinate system, high-

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“…Relatedly, reduced volume of the OFC measured during adulthood has been associated with childhood adversity (Clausen et al, 2019;Dannlowski et al, 2012). Consistent with these individual findings, a voxel-wise meta-analysis of data from 693 children, adolescents, and adults found evidence of reduced OFC volume as a function of childhood maltreatment (Lim et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Corticolimbic Circuit Structure Moderates an Association Between Early Life Stress and Later Trait Anxiety

Kim

Farber

Knodt

et al. 2019

Preprint

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156 words, Article Body: 3,390 words 1 Figure, 0 Table 1 Supplemental Material 2 AbstractChildhood adversity is associated with a wide range of negative behavioral and neurodevelopmental consequences. However, individuals vary substantially in their sensitivity to such adversity. Here, we examined how individual variability in structural features of the corticolimbic circuit, which plays a key role in emotional reactivity, moderates the association between childhood adversity and later trait anxiety in 798 young adult university students. Consistent with prior research, higher self-reported childhood adversity was significantly associated with higher self-reported trait anxiety.However, this association was attenuated in participants with higher microstructural integrity of the uncinate fasciculus and greater thickness of the orbitofrontal cortex. These structural properties of the corticolimbic circuit may capture a neural profile of relative resiliency to early life stress, especially against the negative effects of childhood adversity on later trait anxiety. More generally, our findings highlight the potential utility in the simultaneous consideration of qualitatively different brain structural measures in explaining complex behavioral associations in future research.

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Machine Learning Analysis of the Relationships Between Gray Matter Volume and Childhood Trauma in a Transdiagnostic Community-Based Sample

Cited by 19 publications

References 52 publications

Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach

Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach

Corticolimbic circuit structure moderates an association between early life stress and later trait anxiety

Corticolimbic Circuit Structure Moderates an Association Between Early Life Stress and Later Trait Anxiety

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