Corticolimbic circuit structure moderates an association between early life stress and later trait anxiety

Abstract

Each participant was scanned using one of the two identical research-dedicated GE MR750 3T scanner equipped with high-power high-duty-cycle 50-mT/m gradients at 200 T/m/s slew rate, and an eight-channel head coil for parallel imaging at high bandwidth up to 1 MHz at the Duke-UNC Brain Imaging and Analysis Center. For dMRI data, following an ASSET calibration scan, diffusion-weighted images were acquired across two consecutive 2-min 50-s providing full brain coverage with 2 mm isotropic resolution and 15 diffusion-weighted directions (echo time (TE) = 84.9 ms, repetition time (TR) = 10,000 ms, b value = 1,000 s/mm 2 , field of view (FOV) = 240 mm, flip angle = 90°, matrix = 128 × 128, slice thickness = 2 mm). For fMRI data, first a semi-automated high-ordershimming program was used to ensure global field homogeneity. A series of 34 interleaved axial functional slices aligned with the anterior commissure-posterior commissure plane were acquired for full-brain coverage using an inverse-spiral pulse sequence to reduce susceptibility artifacts (TR/TE/flip angle=2000 ms/30 ms/60; FOV=240mm; 3.75×3.75×4mm voxels; interslice skip=0). Four initial radiofrequency excitations were performed (and discarded) to achieve steady-state equilibrium. To allow for spatial registration of each participant's data to a standard coordinate system, high-

White matter integrity moderates the relation between experienced childhood maltreatment and fathers’ behavioral response to infant crying

“…As such, the UF plays an important role in “valence‐based biasing of decisions” and in the incorporation of reward and punishment history into memory‐dependent processes (Von der Heide et al., 2013 ). Likewise, higher structural integrity of the UF has previously been shown to protect against the well‐documented relation between childhood maltreatment and later anxiety and stress resilience (Kim et al., 2019 ). Additionally, activity and connectivity of the prefrontal cortex has recently been found to be an important differential susceptibility marker for the effects of environmental influences on child development (Crone et al, 2020 ).…”

Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood

“…To be eligible for the DNS, all participants were free of: (1) medical diagnoses of cancer, stroke, head injury with loss of consciousness, untreated migraine headaches, diabetes requiring insulin treatment, chronic kidney or liver disease, or lifetime history of psychotic symptoms; (2) use of psychotropic, glucocorticoid, or hypolipidemic medication; and (3) conditions affecting cerebral blood flow and metabolism (e.g., hypertension) [ 77 ]. Neither past nor present diagnosis of Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition (DSM-IV) Axis I or select Axis II disorders (borderline and antisocial personality disorders) were exclusion criterion because the DNS seeks to establish broad variability in multiple behavioral phenotypes related to psychopathology [ 79 ]. Categorical diagnoses were assessed by trained staff using the electronic Mini International Neuropsychiatric Interview [ 80 ] and Structured Clinical Interview for the DSM-IV subtests [ 81 ].…”

Neurobiological Correlates of Resilience During Childhood and Adolescence: A Systematic Review

“…All other studies that investigated the neural correlates of resilience to internalizing problems (Keding et al, 2021;Lu et al, 2017), including trait anxiety (M. J. Kim et al, 2019), reported null findings.…”

“…Two studies investigated the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) to anterior temporal regions. Of these studies, Chahal et al (2021) found that higher UF fiber density and crosssection (a measure of fiber bundle compactness and width) were associated with lower internalizing symptoms in adolescents with high early life stress, whilst Kim et al (2019) found a null effect for UF fractional anisotropy (FA; a measure of the fraction of diffusion that is directionally dependent). Ohashi et al (2019) examined white matter network structure using graph theory and found no difference in global network architecture between resilient and susceptible youths, but resilient youths did show decreased nodal efficiency and centrality in the amygdala as compared to both susceptible youths and healthy controls.…”