Lymphomatoid papulosis update. A historical perspective

In search of prognostic indicators for lymphomatoid papulosis: A retrospective study of 123 patients

“…Further studies are necessary to determine if different patterns of immune response might be acting in each subtype to halt the progression to lymphoma and/or to coordinate the skin homing mechanisms of atypical lymphocytes. [25][26][27][28][30][31][32] These findings suggest that a positive TCRGR (OR 5.7) and a diagnosis of mixed-type LyP (OR 4.33) may be prognostic tools that can help predict which patients have disease that is more prone to progress to lymphoma. Our findings also suggest that the CD8 phenotype is not necessarily a poor prognostic sign.…”

“…[25][26][27][28][29][30][31][32] The trafficking of lymphocytes to the skin, a key feature of immune surveillance, is accomplished by a coordinated sequence of events involving chemokineinduced migration of leukocytes into target tissues and the homing of lymphoma cells to the skin. 25,26 In MF, the pattern of expression has been correlated with tumor phase and progression.…”

Persistent agmination of lymphomatoid papulosis: An equivalent of limited plaque mycosis fungoides type of cutaneous T-cell lymphoma

“…4 A condition that may coexist with MF is ''lymphomatoid papulosis'' (LyP) a term coined by Macaulay. 5,6 LyP has many histologic features in common with MF but the clinical features are distinctly different. Morphologically, LyP lesions tend to be 4-to 20-mm papulonodules that often ulcerate, self-heal, and scar.…”

A Rational Approach to the Therapy of Cutaneous T–Cell Lymphomas

“…usually, has a good prognosis despite its cytomorphologic relationship to the respective group of nodal high-grade malig nant lymphomas. From a viewpoint integrating molecular biololgy, histology, and clinical features, CTCL include a spectrum of clonal T-cell accumulations in the skin having clinically benign, possible prelymphomatous diseases at one end (clonal dermatitis [5], small plaque parapsoriasis ['an abortive lymphoma') [6], lymphomatoid papulosis ('latent lymphoma') [7] and definitely aggressive lymphomas on the other (MF after transformation into high-grade lymphoma) [5],…”