In search of prognostic indicators for lymphomatoid papulosis: A retrospective study of 123 patients

Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis

“…Type C has been suggested as a risk factor, whereas type B reportedly plays a protective role [7]. However, in a recent study, only a mixed histological subtype was shown to correlate with increased risk for associated lymphoma in patients with LyP [20]. Older age has also been pointed as a risk factor for association between LyP and another lymphoma in one study [7], but this finding was not confirmed in a more recent and larger one [18].…”

“…Diagnosis may precede or be concomitant with that of LyP, or occur during the course of LyP [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The exact frequency of the association between LyP and another lymphoma remains unclear in the literature. It varies from the commonly cited rates of 10%-20% up to 40% and even 60% in some recent studies [3,[7][8][9][10][11][12][13][14][15][16][17][18][19][20]. This discrepancy led Gruber et al [19] to reassess the cumulative risk of developing an associated lymphoma in patients with LyP on the basis of the largest series [8,[12][13][14].…”

Type D Lymphomatoid Papulosis: An uncommon Variant. A case report and review of the literature

“…The term lymphomatoid papulosis originally was used by Macaulay in 1968 to describe "a self-healing rhythmical paradoxical eruption, histologically malignant but clinically benign" [5][6][7]. Before introduction of the term lymphomatoid papulosis, several cases of continuing self-healing eruptions were diagnosed by some authors as a variety of Mucha-Habermann Disease [6].…”

“…However, the classification system for cutaneous lymphomas has evolved rapidly, and, during consensus meetings in 2003-2004, the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification grouped lymphomatoid papulosis among the indolent cutaneous T-cell lymphomas within the spectrum of CD30-positive lymphoproliferative disorders. The rationale for classifying lymphomatoid papulosis as a cutaneous lymphoma is its association with other malignant lymphoproliferative disorders; however, even today some experts hesitate to classify this chronic skin disease as a true malignancy because of its spontaneous resolution and benign clinical course considering it as a pseudolymphomatous inflammatory process [1,7,8]. It was not until recently that there were just three histological variants of LyP known (A, B and C).…”

“…Some lesions ulcerate and develop a necrotic eschar or crust. Their size varies, but usually do not exceed 2cm [7][8][9][10][14][15][16]. They can be a few or a thousand of them, being in mayority of cases scattered and symmetrically distributed affecting principally trunk and proximal limbs.…”