1996
DOI: 10.1159/000218803
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A Rational Approach to the Therapy of Cutaneous T–Cell Lymphomas

Abstract: Cutaneous T-cell lymphomas (CTCL) comprise a heterogeneous group of rare diseases that are characterized by a clonal accumulation of T lymphocytes (mainly CD4+) in the skin. The diagnosis is established using an adapted Kiel classification. For staging the present TNM system can be applied, although it is certainly not optimized yet. The choice of treatment modalities depends on the extent and the aggressiveness of CTCL (low- or high-grade lymphoma) and on the individual situation of the patient. A stage-adapt… Show more

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Cited by 24 publications
(12 citation statements)
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“…4 IFN-␣, alone or in combination with retinoids or psoralen plus ultraviolet A irradiation, is helpful, especially in early disease. 5 Interferons are known for their pleiotropic effects. Besides the up-regulation of major histocompatibility complex molecules and the inhibition of cell proliferation and tumor growth, IFN can induce resistance to viral replication in all cells.…”
Section: Introductionmentioning
confidence: 99%
“…4 IFN-␣, alone or in combination with retinoids or psoralen plus ultraviolet A irradiation, is helpful, especially in early disease. 5 Interferons are known for their pleiotropic effects. Besides the up-regulation of major histocompatibility complex molecules and the inhibition of cell proliferation and tumor growth, IFN can induce resistance to viral replication in all cells.…”
Section: Introductionmentioning
confidence: 99%
“…Therapeutic approaches include stage-dependent selection of PUVA (psoralen and ultra violet A), retinoids, interferon ␣-2a in combination with acitretin or PUVA (5)(6)(7)(8), various immunomodulators (9), electron radiation (10), or extracorporeal photopheresis (11). These methods are successful in early, but not in the aggressive, later stages of the disease.…”
mentioning
confidence: 99%
“…In the overall analysis, there was no impact of aggressive treatment on disease-free or overall survival [18]. Therefore, a rather mild stage-adapted therapy is recommended for MF [19]. In early stages, local treatment approaches such as topical steroids, PUVA (psoralen plus UVA), locally applied cytostatic drugs such as mechlorethamine [20], BCNU [21], electron beam radiotherapy, or soft X-ray therapy [19] can be used.…”
Section: Therapy Of Cutaneous T-cell Lymphomas (Ctcl) Mycosis Fungoidmentioning
confidence: 99%