Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Pandır, Dilek; Ünal, Betül; Baş, Hatice

doi:10.1590/1678-4324-2016150794

Cited by 11 publications

(12 citation statements)

References 33 publications

(34 reference statements)

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“…In the present study, the administration of lycopene for 28 days revealed a reduction of cardiotoxicity in diabetic rats. The protective role of lycopene on cells was seen in previous studies, too Boyacioglu et al, 2016;Lopez-Jornet et al, 2016;Pandir et al, 2016).…”

Section: Stz-caused Dm Induces Oxidative Stress and Then Hyperglycemimentioning

confidence: 53%

“…In fact, it is well documented that increasing oxidative stress initiates DM formation (Bas et al, ; Jaganjac, Tirosh, Cohen, Sasson, & Zarkovic, ). Kalender et al, () and Pandır et al, () indicated a relevance between DM and enhanced MDA content. MDA is used at designated levels of lipid peroxidation (LPO).…”

Section: Discussionmentioning

confidence: 95%

“…Cong et al (2015) and Chen et al (2016) who find eosinophilia in myocardial fibers and edema in connective tissue. Also, chemicals can cause histopathological changes in tissues, such as: liver (Bas, Pandır, & Kalender, 2016), kidneys (Pandir et al, 2016), and testes (Kara, Baş, & Pandır, 2016). Heart is one of the organs that is affected by chemical treatment.…”

Section: Stz-caused Dm Induces Oxidative Stress and Then Hyperglycemimentioning

confidence: 99%

“…It is also observed in environmental factors such as: tobacco and wood smoke, and engine exhaust, (Jackson et al, ). In respect to nutrition, the engagement of furan is a harmful attention for the reason that the high proportions doses of furan are dangerous to the living cell (Baş & Pandır, ; Pandir, Unal, & Bas, ).…”

Section: Introductionmentioning

confidence: 99%

“…However, there are currently a few research works into the protective acts of lycopene opposite furan‐induced cardiotoxicity of the diabetic rat (Pandır et al, ). For this reason, the purpose of this study is to demonstrate the cardio protective and antioxidative role of lycopene on furan‐caused cardiotoxicity models in diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

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Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Saracoğlu¹,

Baş

Pandır

2018

J Food Biochem

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The objective of this current study is to search the impacts of furan and lycopene on a diabetic rat's heart. Diabetes increases prevalence with a sedentary lifestyle and obesity. Furan, a carcinogen, was detected in foods that had undergone thermal treatment. Two groups were formed, such as: the control and diabetic groups. Diabetic groups fall into four allocated groups: control, lycopene, furan, and furan + lycopene. The changes in malondialdehide levels, antioxidant enzymes’ activities, and histopathology of the heart were pointed out. We observed that the changes in both the MDA level and the antioxidant enzymes’ activities were due to diabetes. Furan‐induced increment in MDA levels, but GST, CAT, SOD, and GPx activities showed a decrease. Lycopene influenced these changes positively. In terms of the pathological studies, changes were also observed in diabetic rats. The histological damage in the diabetic furan groups was found to be very serious. Lycopene was protective against furan that caused histopathological changes. Diabetes and furan resulted into heart damages in rats and lycopene showed preventive effects. But this was not a complete protection. Practical applications Furan by product of chlorinated chemical compounds production and chemical processes including combustion, are virtually ubiquitous in the environment. Because of this, furan occur potential risk for human health. Furan is known to exist at higher levels in fatty foods, such as full‐fat milk and dairy products, meat and eggs. They can accumulate in the fatty tissues of animals and humans. Diabetes increase in the prevalence of a sedentary lifestyle and obesity. Diabetes with furan‐induced cardiotoxicity. Foods should not be heated over and over again, especially diabetic heart patients should stay away from this situation.

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Section: Stz-caused Dm Induces Oxidative Stress and Then Hyperglycemimentioning

confidence: 53%