Luteolin enhances TNF-related apoptosis-inducing ligand’s anticancer activity in a lung cancer xenograft mouse model

Yan, Jiaqi; Wang, Qiong; Zheng, Xuelian; Sun, Hong; Zhou, Yuqiong; Li, Daoxia; Lin, Yong; Wang, Xia

doi:10.1016/j.bbrc.2011.12.055

Cited by 45 publications

(23 citation statements)

References 20 publications

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“…The previous in vitro studies have shown that luteolin induces apoptosis process through TRAIL. The TRAIL inducing sensitization of cells leading to apoptosis in a different type of cells was confirmed by mouse model and cell studies (Yan et al, ).…”

Section: Pharmacological Activities Of Luteolinmentioning

confidence: 84%

Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives

et al. 2019

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Luteolin is a 3′, 4′, 5, 7 tetra hydroxyl flavonoid that exits in many plants, fruits, and vegetable. Many methods of extraction, isolation, and purification are being used, and therapeutic properties are being under discussion due to its valuable role in nutrition and human health. In this review, we have summarized conventional and novel extraction techniques from most recent research on luteolin, its derivatives, and its biological activities. Maceration, soxhlet, reflux, hydrodistillation, ultrasound‐assisted extraction, microwave‐assisted extraction, ultrasound microwave‐assisted extraction, enzyme‐assisted extraction, supercritical fluid extraction, and high‐speed counter‐current chromatography extraction techniques are being used for isolation and purification of these phytochemicals. The anti‐inflammatory, anti‐cancer, antioxidant, antiviral, heart protective, neurological impairments protection, anti‐aging, and whiting properties have been discussed in this review. The literature suggests luteolin and its derivative has many promising health benefits and its therapeutic activity is strongly associated with isolating and purifying solvents and extraction techniques. Practical applications This review aims to highlight the sources, novel extraction techniques, and pharmaceutical properties of luteolin. This review provides enough knowledge about how to get maximum extraction yield of luteolin using the novel extraction techniques. Because its therapeutic activity is strongly associated with isolating and purifying solvents and techniques.

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Section: Pharmacological Activities Of Luteolinmentioning

confidence: 84%

Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives

et al. 2019

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“…These increases of tumor mass iNOS immunoreactivities are considered as secondary changes from immune stimulatory effects of platycodin D related to NK cell activity. In addition, significant increases of tumor mass TNF- α , a representative cytokine involved in tumor necrosis [ 68 ] immunoreactivities were also demonstrated in all three different dosages of platycodin D as compared with tumor-bearing control mice, respectively. Gemcitabine did not influence tumor mass iNOS and TNF- α immunoreactivities in this experiment.…”

Section: Discussionmentioning

confidence: 99%

In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell

Park

Lee

Choi

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Platycodin D is a major pharmacological constituent of Platycodi radix and has showed various pharmacological activities through oxidative stress defense mechanisms. Here, possible antitumor, anticachexia, and immunomodulatory activities of platycodin D were observed on the H520 tumor cell-bearing athymic nude mice after confirming the in vitro cytotoxicity. Platycodin D was orally administered at dose levels of 200, 100, and 50 mg/kg, once a day for 35 days from 15 days after implantation. The results were compared with gemcitabine 160 mg/kg intraperitoneally treated mice (7-day intervals). Platycodin D showed favorable cytotoxic effects on the H520 cells, and also dose-dependently decreased the tumor volumes and weights with increases of apoptotic cells (caspase-3 and PARP immunopositive cells), iNOS and TNF-α immunoreactivities, decreases of COX-2 immunoreactivities in tumor masses. Platycodin D also showed dose-dependent immunostimulatory and anticachexia effects. Gemcitabine showed favorable cytotoxity against H520 tumor cell and related in vivo antitumor effects but aggravated the cancer related cachexia and immunosuppress in H520 tumor cell-bearing athymic nude mice. Taken together, it is considered that oral treatment of platycodin D has potent antitumor activities on H520 cells through direct cytotoxic effects, increases of apoptosis in tumor cells, and immunostimulatory effects and can be control cancer related cachexia.

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“…Baicalein enhances TRAIL-induced death in SW480 colon and PC3 prostate cancer cells [45]. Luteolin reverses TRAIL resistance in CNE1 nasopharyngeal, in HeLa cervical, A549 lung, HT29 colon, SW780 and RT112 bladder, 786O, ACHN and A498 renal cancer cells and HepG2 hepatoma cells [55,56,57,58,59]. …”

Section: Discussionmentioning

confidence: 99%

Novel Structurally Related Flavones Augment Cell Death Induced by rhsTRAIL

Bronikowska

Szliszka

Kostrzewa-Susłow

et al. 2017

IJMS

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TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) was identified as a powerful activator of apoptosis in tumor cells and one of the most promising candidates for cancer therapy with no toxicity against normal tissues. However, many tumor cells are resistant to TRAIL-induced apoptosis. The aim of this work was to analyze the improvement of the anticancer effect of rhsTRAIL (recombinant human soluble TRAIL) by nine flavones: 5-Hydroxyflavone, 6-Hydroxyflavone, 7-Hydroxyflavone and their new synthetic derivatives 5-acetoxyflavone, 5-butyryloxyflavone, 6-acetoxyflavone, 6-butyryloxyflavone, 7-acetoxyflavone and 7-butyryloxyflavone. We examined the cytotoxic and apoptotic effects of rhsTRAIL enhanced by novel structurally-related flavones on SW480 and SW620 colon cancer cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test, the lactate dehydrogenase assay and annexin V-FITC fluorescence staining. We observed a slight difference in the activities of the flavones that was dependent on their chemical structure. Our study indicates that all nine flavones significantly augment cell death by rhsTRAIL (cytotoxicity range 36.8 ± 1.7%–91.4 ± 1.7%; apoptosis increase of 33.0 ± 0.7%–78.5 ± 0.9%). Our study demonstrates the potential use of tested flavones in TRAIL-based anticancer therapy and prevention.

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Luteolin enhances TNF-related apoptosis-inducing ligand’s anticancer activity in a lung cancer xenograft mouse model

Cited by 45 publications

References 20 publications

Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives

Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives

In Vivo and In Vitro Antitumor Effects of Platycodin D, a Saponin Purified from Platycodi Radix on the H520 Lung Cancer Cell

Novel Structurally Related Flavones Augment Cell Death Induced by rhsTRAIL

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