Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives

Abstract

Luteolin is a 3′, 4′, 5, 7 tetra hydroxyl flavonoid that exits in many plants, fruits, and vegetable. Many methods of extraction, isolation, and purification are being used, and therapeutic properties are being under discussion due to its valuable role in nutrition and human health. In this review, we have summarized conventional and novel extraction techniques from most recent research on luteolin, its derivatives, and its biological activities. Maceration, soxhlet, reflux, hydrodistillation, ultrasound‐assisted extraction, microwave‐assisted extraction, ultrasound microwave‐assisted extraction, enzyme‐assisted extraction, supercritical fluid extraction, and high‐speed counter‐current chromatography extraction techniques are being used for isolation and purification of these phytochemicals. The anti‐inflammatory, anti‐cancer, antioxidant, antiviral, heart protective, neurological impairments protection, anti‐aging, and whiting properties have been discussed in this review. The literature suggests luteolin and its derivative has many promising health benefits and its therapeutic activity is strongly associated with isolating and purifying solvents and extraction techniques. Practical applications This review aims to highlight the sources, novel extraction techniques, and pharmaceutical properties of luteolin. This review provides enough knowledge about how to get maximum extraction yield of luteolin using the novel extraction techniques. Because its therapeutic activity is strongly associated with isolating and purifying solvents and techniques.

Thermo-Ultrasound-Based Sterilization Approach for the Quality Improvement of Wheat Plantlets Juice

“…Moreover, it was also noted that the impact was more obvious in the case of the US45-30 and US45-45 treatments. The reduction in TFC might be associated with the higher treatment temperature applied during processing as it causes the decomposition of functional compounds [29,30]. Our outcomes concerning a decrease in bioactive compounds are in line with the search of Rawson et al [16], who described that these compounds reduced with increase in treatment temperature from 25 to 45 • C in watermelon juice treated TU.…”

Pulsed Electric Field-Assisted Ethanolic Extraction of Date Palm Fruits: Bioactive Compounds, Antioxidant Activity and Physicochemical Properties

“…This difference might be due permeabilization of plant cells by PEF application to yield more fruit extracts production, increase the extractability and enhance the intracellular metabolites extraction [33]. The presence of some enzymes can affect the TPC which are responsible for phenolic biosynthesis, and the induction of these enzymes activity can increase the accumulation of TPC [34,35]. As given in Table 1, the TFC results showed a significant increase in the TFC of DPFE (DPFE3 > DPFE2 > DPFE1) as compared to untreated extract.…”

Novel processing techniques and spinach juice: Quality and safety improvements

“…The conventional thermal techniques are less energy cost‐effective, environment‐friendly, and processing losses. But novel technologies (PEF and US) require very low operating energy and accelerate the processes (Siddeeg et al., 2019b), improve the quality of products, and eliminate or reduce disadvantageous impacts on the environment (Ahmad et al., 2019; Manzoor et al., 2019b; Zhang, Wang, Zeng, Han, & Brennan, 2019). These nonthermal techniques ensure a notable decrease in microbial activity, higher shelf life and safe consumption of food products (Ahmed et al., 2019; Zia, Khan, Zeng, Shabbir, & Aadil, 2019).…”