Lufenuron no tratamento da dermatofitose em gatos?

Abstract

Due to discrepancies regarding the effectiveness of lufenuron in treating dermatophytosis caused by Microsporum canis the effect of this drug was checked in 46 cats (30 with cutaneous lesions and 16 asymptomatic carriers) treated in the Veterinary Hospital of the Federal Rural University of Rio de Janeiro, Brazil. The diagnosis was based on Wood's lamp examination and fungal cultures. Biopsies were only performed in symptomatic animals. The animals were treated with lufenuron (120mg/kg every 21 days), for 4 times. The drug was efficient in 29 of the 30 affected felines and as well as in all of the asymptomatic carriers. The cat that did not respond, had received several dexametazone doses prior to the treatment with lufenuron. The drug was given to one animal during the first stages of pregnancy and no abnormalities or neonatal disorders were found in any of the kittens. None of the treated animals showed side effects. Twenty days after the last administration of lufenuron, 45 of the studied animals (98%) had negative fungal culture. The cost of treating dermatophytosis with lufenuron is a little higher than with ketoconazole, but the drug has some advantages regarding its practicability and security. The correct drug prescription and animal's medication as well as environmental decontamination are very important for the success of the treatment.

Diagnosis and treatment of dermatophytosis in dogs and cats.

“…Fifty seven studies involving either spontaneous ( n = 42) or experimental ( n = 15) M. canis infections in cats and dogs ( n = 2,027) were identified and of these, 30 described Wood's lamp findings . When data were pooled from studies describing the first examination of animals with spontaneous disease, 72% (378 of 523) of animals were Wood's lamp positive . In untreated cats, positive fluorescence varied from 91 to 100%, and in animals with previous treatment fluorescence varied from 39 to 53%.…”

“…In a study from Brazil, 46 Persian and mixed breed cats were treated with 120 mg/kg lufenuron orally every 21 days for 84 days. Except for two cats, all were culture negative at the end of treatment . In a second study from Brazil, 49 dogs and cats were divided into four treatment groups each receiving a different dose of lufenron .…”

Isolation and identification of Trichophyton mentagrophytes as a cause of fungal otitis in cats: Case Report

“…Para o caso em questão, no qual ficou evidenciada a presença do fungo dermatófito Tricophyton mentagrophytes, a literatura recomenda a utilização de fungicidas tais como a griseofulvina, cetoconazol ou itraconazol, via oral por um período de tempo variando de 60 a 90 dias, com avaliações posteriores para definição da cura clínica e suspensão do tratamento (Ramadinha et al, 2010).…”