&lt;p&gt;The role of salivary sIgA as protection for dental caries activity in Indonesian children&lt;/p&gt;

Soesilawati, Pratiwi; Notopuro, Harianto; Yuliati, Yuliati; Ariani, Maretaningtias Dwi; Firdauzy, Muhammad Alwino Bayu

doi:10.2147/ccide.s194865

Cited by 14 publications

(24 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These molecules include those related to the immune system such as immunoglobulins, antimicrobial peptides, and proteins of the complement system [ 12 ]. For example, IgA and cathelicidin LL-37 concentrations have been shown to be related to oral health [ 13 , 14 ]. IgA acts as the first immunological defence agent on the surface of the oral mucosa and teeth because it interferes with bacterial colonization and neutralizes toxins, viruses, and other types of microorganisms [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Díaz

Simón-Soro

Forero

et al. 2021

Journal of Oral Microbiology

View full text Add to dashboard Cite

Background: Electrolytes, proteins, and other salivary molecules play an important role in tooth integrity and can serve as biomarkers associated with caries. Objective: To determine the concentration of potential biomarkers in children without caries (CF) and children with caries (CA). Methods: Unstimulated saliva was collected, and the biomarkers quantified in duplicate, using commercial Enzyme Linked Immunosorbent Assay (ELISA) kits to determine IgA, fibronectin, cathelicidin LL-37, and statherin levels, as well as colorimetric tests to detect formate and phosphate. Results: Significantly higher concentrations of statherin was detected in the CF group (Median: 94,734.6; IQR: 92,934.6–95,113.7) compared to the CA2 group (90,875.0; IQR: 83,580.2–94,633.4) (p = 0.03). Slightly higher median IgA (48,250.0; IQR: 31,461.9–67,418.8) and LL-37 levels (56.1; IQR 43.6–116.2) and a lower concentration of formate were detected in the CF group (0.02; IQR 0.0034–0.15) compared to the group with caries (IgA: 37,776.42; IQR: 33,383.9–44,128.5; LL-37: 46.3; IQR: 40.1011–67.7; formate: 0.10; IQR: 0.01–0.18), but these differences were not statistically significant. Conclusion: The fact that these compounds have been identified as good markers for caries among European adults highlights the difficulty of identifying universal biomarkers that are applicable to all ages or to different populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Díaz

Simón-Soro

Forero

et al. 2021

Journal of Oral Microbiology

View full text Add to dashboard Cite

show abstract

“…The results of the correlation between salivary s-IgA levels and the severity of dental caries were shown in Figure 5 . Because of the limited number of studies on differences in the severity of caries (only nine studies were included) [ 21 , 25 , 5 , 33 , 36 , 38 , 39 , 41 , 46 ], and the heterogeneity in the studies was greater than 50% ( I 2 >50%), a random-effects model was used ( P <0.001). The results show that when comparing the salivary s-IgA levels of patients with high dental caries and patients with low dental caries ( Figure 5 A), we found that the salivary s-IgA levels of patients with high dental caries were significantly lower than those of patients with low dental caries (SMD = −0.89, 95%CI: [−1.46; −0.31], P =0.003).…”

Section: Resultsmentioning

confidence: 99%

“…The results obtained by the above studies may be due to the small sample size and different criteria for judging dental caries. Besides, it is recommended that salivary s-IgA levels be measured in children over the age of 6, whose immune system is considered complete [ 46 ]. Jafarzadeh et al [ 67 ] found that salivary s-IgA levels increase with age before the age of 60, and slightly decrease in the 61–70 age group.…”

Section: Discussionmentioning

confidence: 99%

“…with acceptable heterogeneity (I 2 =46%).The 22, 25, 27, 5,32,33,34,38,39,44,45,46,47,48 caries-free healthy control group included 265 study subjects and the caries group included 410 study subjects, and the combined meta-analysis of caries activity was performed at lower levels of s-IgA (SMD=-1.23, 95%CI: [-1.48; -0.99], P<0.001). In the sensitivity analysis, the removal of any individual study did not change the overall statistical significance, indicating that the meta-analysis was relatively stable and reliable (Figure 7).…”

mentioning

confidence: 99%

“…over the age of 6, whose immune system is considered complete[46]. Jafarzadeh's et al[67] found that salivary s-IgA levels increase with age before the age of 60, and slightly decrease in the 61-70 age group.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Gong

Wang

et al. 2020

Bioscience Reports

View full text Add to dashboard Cite

Objective: To determine the levels of s-IgA in saliva of caries patients and healthy controls, and to evaluate whether there is a correlation between it and caries by meta-analysis. Methods: The PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, Scopus, Chinese National Knowledge Infrastructure, Wanfang Data, Chongqing VIP database for Chinese Technical Periodicals, and China BioMedical Literature Services System databases were searched initially in April 2020 and repeated in August 2020. Two independent evaluators screened the literature and extracted the data according to the inclusion and exclusion criteria. R 4.0.2 software was used for meta-analysis. I2 test was commonly reflected the heterogeneity. Subgroup analysis and meta-regression analysis explore the sources of heterogeneity. Sensitivity analysis, funnel diagram, Begg’s rank correlation, and Egger’s linear regression were used to determine the possibility of publication bias. Results: The study was reviewed according to the project guidelines for optimal reporting (PRISMA) based on meta-analysis. A total of 30 case–control studies were included, with a total sample size of 1545 patients, including 918 caries patients and 627 healthy controls. Salivary s-IgA levels in caries patients were significantly lower than those in healthy controls (SMD = −0.49, 95%CI: [−0.94; −0.03], P=0.03). In addition, the results of subgroup analysis showed that the significant decrease of salivary s-IgA level was correlated with children patients, mixed dentition and Asian people (children: SMD = −0.45, 95%CI: [−0.89; −0.01], P=0.04; mixed dentition: SMD = −0.61, 95%CI: [−1.24; 0.03], P=0.06; Asian: SMD = −0.62, 95%CI: [−1.17; −0.08], P=0.02). The funnel diagram included in the study was symmetrically distributed, and the sensitivity analysis confirmed the robustness of the results. Conclusion: Salivary s-IgA levels in caries patients were significantly lower than in healthy controls. It has also been demonstrated that salivary s-IgA may be used as an alternative measure to identify subjects at risk of caries susceptibility, suggesting that salivary s-IgA may be a protective factor for dental caries.

show abstract

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Özler

Duruel

Pınar

et al. 2022

Pediatric Pulmonology

View full text Add to dashboard Cite

Purpose: To evaluate the caries status of the Cystic fibrosis (CF) children and adolescents with the comparation of some biochemical markers, secretoryimmunoglobulin-A (sIgA), and antimicrobial peptides in the saliva. Methods:In this cross-sectional descriptive study, the approval Ethics Board was obtained. Unstimulated saliva samples were collected from CF and healthy control children (non-CF) patients. Both groups underwent the same dental and periodontal evaluation scheme of the assessment. Human beta defensin (HBD1), human alpha defensin (HNP-1), cathelicidin (LL-37), sIgA in saliva were evaluated by enzymelinked immunoassay method. A general biochemical analysis was performed.Statistical analysis was performed by using Statistical Package for the Social Sciences Version 20.0 (SPSS Inc.).Results: A total of 21 (9 male, 12 female) CF and 23 (11 male, 12 female) control patients were participated with the mean age of 10.17 ± 3.38 and 9.52 ± 2.15 years, respectively. In control children, DMFT/S (decayed-missing-filled-tooth/surface-inpermanent-dentition), dmft/s (decayed-missing-filled-tooth/surface-in-primarydentition) values were higher; DT (decayed-tooth in permanent dentition), ft (filled-tooth in primary dentition) and plaque index values were statistically significantly higher (p = 0.042, p = 0.005, p = 0.038, respectively) than CF patients. Bicarbonate was higher in control group; sodium, chloride, and total protein were higher in CF group; magnesium, calcium and phosphate levels were similar in each group (p > 0.05). Alpha and beta defensin-1 levels in control group was statistically significantly higher (p = 0.037 and p = 0.020, respectively), while LL37 and sIgA were not statistically significantly higher (p > 0.05) than CF group.Conclusions: Children with CF had lower caries in permanent teeth, filling in primary teeth, and an altered salivary biomarker profile, especially in HNB1, HNP1. Therefore, it is important to conduct periodic oral-dental controls among CF patients during their childhood.

show abstract

<p>The role of salivary sIgA as protection for dental caries activity in Indonesian children</p>

Cited by 14 publications

References 20 publications

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Dental caries and associated salivary biomarkers in patients with cystic fibrosis

Contact Info

Product

Resources

About