Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Abstract

Objective: To determine the levels of s-IgA in saliva of caries patients and healthy controls, and to evaluate whether there is a correlation between it and caries by meta-analysis. Methods: The PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, Scopus, Chinese National Knowledge Infrastructure, Wanfang Data, Chongqing VIP database for Chinese Technical Periodicals, and China BioMedical Literature Services System databases were searched initially in April 2020 and repeated in August 2020. Two independent evaluators screened the literature and extracted the data according to the inclusion and exclusion criteria. R 4.0.2 software was used for meta-analysis. I2 test was commonly reflected the heterogeneity. Subgroup analysis and meta-regression analysis explore the sources of heterogeneity. Sensitivity analysis, funnel diagram, Begg’s rank correlation, and Egger’s linear regression were used to determine the possibility of publication bias. Results: The study was reviewed according to the project guidelines for optimal reporting (PRISMA) based on meta-analysis. A total of 30 case–control studies were included, with a total sample size of 1545 patients, including 918 caries patients and 627 healthy controls. Salivary s-IgA levels in caries patients were significantly lower than those in healthy controls (SMD = −0.49, 95%CI: [−0.94; −0.03], P=0.03). In addition, the results of subgroup analysis showed that the significant decrease of salivary s-IgA level was correlated with children patients, mixed dentition and Asian people (children: SMD = −0.45, 95%CI: [−0.89; −0.01], P=0.04; mixed dentition: SMD = −0.61, 95%CI: [−1.24; 0.03], P=0.06; Asian: SMD = −0.62, 95%CI: [−1.17; −0.08], P=0.02). The funnel diagram included in the study was symmetrically distributed, and the sensitivity analysis confirmed the robustness of the results. Conclusion: Salivary s-IgA levels in caries patients were significantly lower than in healthy controls. It has also been demonstrated that salivary s-IgA may be used as an alternative measure to identify subjects at risk of caries susceptibility, suggesting that salivary s-IgA may be a protective factor for dental caries.

The Effect of Oral Probiotics (Streptococcus Salivarius k12) on the Salivary Level of Secretory Immunoglobulin A, Salivation Rate, and Oral Biofilm: A Pilot Randomized Clinical Trial

“…Although plaque accumulation rate is a rapidly changing variable and caries development is a relatively slow process, we found a moderate positive correlation between TQHPI values and the number of decayed teeth. There was no significant correlation between the value of the decay component of DMFT and sIgA level, although some authors hypothesized that the level of salivary sIgA may serve as a predictor of caries resistance in a patient [ 27 , 71 , 72 , 73 ].…”

Periodontal disease in down syndrome: Predisposing factors and potential non‐surgical therapeutic approaches

“…51,52 Salivary components such as pH, buffering capacity, and salivary flow volume play an important role in reducing the harmful effects of metabolites produced by the oral microbiota. 51,53 Adequate Salivary flow can effectively dilute and eliminate the products of bacterial metabolism in the oral cavity. The low salivary flow in DS children may contribute to the accumulation of bacterial products, gingivitis and an increased risk of PD.…”

“…Saliva contains numerous organic and inorganic components that maintain the delicate balance of the oral microbiota and prevent the adhesion and penetration of bacteria into the teeth 51,52 . Salivary components such as pH, buffering capacity, and salivary flow volume play an important role in reducing the harmful effects of metabolites produced by the oral microbiota 51,53 . Adequate Salivary flow can effectively dilute and eliminate the products of bacterial metabolism in the oral cavity.…”

Microbiocenoses and the State of Local Mucosal Immunity of the Oral Cavity of Children and Adolescents with Liver Diseases

“…Тривалий контакт з мікроорганізмами викликає сенсибілізацію організму з подальшим зниженням реактивності. Доведений опосередкований механізми дії sIgA через систему активації фагоцитів з подальшим лізисом патогенних мікроорганізмів [19,23,24]. Дані дослідження теж підтвердили цей факт.…”