Low Density Lipoprotein Particle Size is Associated with Glycosylated Hemoglobin Levels Regardless of Plasma Lipid Levels.

Abstract

Weevaluated the influence of the levels of glycosylated hemoglobin (HbAlc) and fasting plasma glucose on the variation in low density lipoprotein (LDL) peak particle size in 210 subjects who were undergoing an annual check-up. Univariate analysis showed that LDLparticle size was significantly and positively correlated with high density lipoprotein (HDL) cholesterol levels, and was inversely correlated with the levels of total plasma cholesterol, triglycerides, fasting glucose, fasting insulin, HbAlc, and body mass index (BMI). Stepwise regression analysis selected four independent contributing variables that could affect LDLparticle size; triglyceride levels, HDL cholesterol levels, LDLcholesterol levels, and HbA1Clevels. Similar regression analysis performed for menand for normotensive subjects showedthat HbAlclevels also independently influenced LDLparticle size. The results indicate that HbAlc levels have a significant effect on LDLparticle size. This suggests that small LDLparticles would be present in subjects with non-insulindependent diabetes mellitus regardless of plasma lipid concentrations.

The Trp64Arg polymorphism of the β3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study

“…This result is consistent with a previous study [27], although the method used in the determination of LDL particle size (at the peak size by electrophoresis using nondenaturing 2% to 16% polyacrylamide gradient gels in plasma samples [28], as originally described by Krauss and Burke [15]) was different. For the LipoPrint System, this is the first description that the area of sdLDL was larger in Arg carriers than in non-Arg carriers, as shown in Table 1.…”

Small Low-Density Lipoprotein Cholesterol Concentration is a Determinant of Endothelial Dysfunction by Peripheral Artery Tonometry in Men

“…In this study, we reported for the first time the close relationship between small LDL cholesterol concentrations and RHI by PAT. Previous studies have shown that a prevalence of small LDL particles is strongly associated with an increase in triglyceride or intermediate density lipoprotein (IDL) cholesterol concentrations 26) , and inversely associated with HDL cholesterol concentrations 27) as characterized in subjects with insulin resistance or metabolic syndrome, but endothelial function assessed by RHI did not exhibit any relationships with them ( Table 3). The present study suggests that RHI is affected by small LDL cholesterol concentrations, but not by the presence of insulin resistance or metabolic syndrome.…”

The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels

“…The LDL particle size was determined by electrophoresis using non-denaturing 4-14% polyacrylamide gradient gels with modified methods (19). In brief, 7.5 ml plasma samples were applied on gels with a final concentration of 20% sucrose and 0.25% bromophenol blue.…”