The Trp64Arg polymorphism of the β3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study

Tsuzaki, Kokoro; Kotani, Kazuhiko; Fujiwara, Shinji; Sano, Yoshiko; Matsuoka, Yukiyo; Domichi, Masayuki; Hamada, Taku; Shimatsu, Akira; Sakane, Naoki

doi:10.1016/j.metabol.2007.07.012

Cited by 8 publications

(10 citation statements)

References 28 publications

(31 reference statements)

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“…Briefly, after serum samples (25 μL) were photopolymerized, the samples and loading gels were applied to gel tubes and then electrophoresed. The scanning system calculated the mean LDL particle size based on the fractionalized lipoproteins [29]. Furthermore, the d-ROMs values were measured using a kinetic spectrophotometric assay (the F.R.E.E system; Diacron, Italy) with intra- and inter-assay coefficients of variation of 2.1% and 3.1%, respectively [22, 23].…”

Section: Methodsmentioning

confidence: 99%

The Correlation Between Small Dense LDL and Reactive Oxygen Metabolites in a Physical Activity Intervention in Hyperlipidemic Subjects

et al. 2012

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BackgroundSmall dense low-density lipoprotein (sdLDL), which has a small LDL particle size with a greater susceptibility to oxidation, is considered a risk marker for cardiovascular disease (CVD). The diacron reactive oxygen metabolites (d-ROMs) have recently been introduced as a clinically useful oxidative stress-related marker. Physical activity can reduce the CVD risk. The present study investigated the correlation between the changes of the mean LDL particle size and the oxidative stress status, as assessed by the d-ROMs, in a physical activity intervention in hyperlipidemic subjects.MethodsWe performed a 6-month intervention study of 30 hyperlipidemic subjects (12 male/18 female, mean age 64 years), focusing on a moderate physical activity increase. The clinical data, including the atherosclerotic risk factors besides the mean LDL particle size measured with the gel electrophoresis and the d-ROMs, were evaluated pre- and post-intervention.ResultsThe mean LDL particle size was significantly larger in the post-intervention than in the pre-intervention evaluation (26.9 ± 0.3 (SD) vs. 27.1 ± 0.4 nm, P < 0.01), while the d-ROMs levels were significantly reduced in the post-intervention period compared to those at pre-intervention (319 ± 77 vs. 290 ± 73 U. Carr., P < 0.05). A stepwise multiple regression analysis revealed that there was an independent, significant and inverse correlation between the pre- and post-intervention changes of the d-ROMs and the mean LDL particle size (β = -0.55, P < 0.01).ConclusionsThe intervention study suggests that sdLDL and oxidative stress can concomitantly affect the risk of developing CVD and that both factors can improve by even a moderate increase in physical activity among hyperlipidemic subjects.

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Section: Methodsmentioning

confidence: 99%

The Correlation Between Small Dense LDL and Reactive Oxygen Metabolites in a Physical Activity Intervention in Hyperlipidemic Subjects

et al. 2012

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“…A total of 277 Japanese community-dwelling subjects (123 men and 154 women, mean age: 65 13 SD) years, range; 24 − 88 years) in the Koyadaira area of Mima city were enrolled in this study (Table 1), which was approved by the Ethics Committee of Kyoto Medical Center 23) . All subjects gave their written informed consent and were recruited during general health check-ups.…”

Section: Methodsmentioning

confidence: 99%

S447X Polymorphism in the Lipoprotein Lipase Gene and the Adiponectin Level in the General Population: Results from the Mima Study

Fujiwara

Kotani

Sano

et al. 2009

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Aim: Lipoprotein lipase (LPL) plays an important role in lipid metabolism. There is an association between the common S447X polymorphism in the LPL gene and high-density lipoprotein cholesterol (HDL-C) levels, and some association between circulating HDL-C and adiponectin levels has been suggested; however, it is not known whether there is any association between the S447X polymorphism and adiponectin levels. The aim of this study was to investigate whether the LPL S447X polymorphism was associated with adiponectin in the general population. Methods: LPL S447X was analyzed in 277 community-dwelling subjects (123 men and 154 women, mean age; 65 13 years) in the Mima study. Whole samples were genotyped using a fluorescent allele-specific DNA primer assay system. The allele frequencies and any associations with serum lipid and adiponectin levels were investigated. Results: The allele frequencies were S 0.875 and X 0.125 for the LPL S447X polymorphism. The carriers of the X allele had significantly higher levels of adiponectin and HDL-C than non-carriers. The presence of the X allele was significantly associated with higher adiponectin levels, independent of age, sex, body mass index, smoking and HDL-C in multiple regression analyses. Conclusion: The LPL S447X polymorphism might therefore be significantly associated with higher adiponectin levels, independent of HDL-C. J Atheroscler

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“…Data from the Mima study [46] indicate that a polymorphism of the beta(3)-adrenergic receptor gene (the genetic marker for obesity-related traits) is correlated with the area percentage of sdLDL ( p < 0.05), independently of age, gender, body mass index (BMI), smoking and IR index, suggesting a genetic predisposition to increased sdLDL in the presence of this polymorphism.…”

Section: Overweight Obesity and Sdldlmentioning

confidence: 99%

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

et al. 2013

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Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in these subjects. Statins are the lipid-lowering drug of choice. Also, anti-obesity and lipid lowering drugs other than statins could be useful in these patients. However, the effects of anti-obesity drugs on CVD risk factors remain unclear. We review the clinical significance of sdLDL in being overweight and obesity, as well as the efficacy of anti-obesity drugs on LDL subfractions in these individuals; a short comment on HDL subclasses is also included. Our literature search was based on PubMed and Scopus listings. Further research is required to fully explore both the significance of sdLDL and the efficacy of anti-obesity drugs on LDL subfractions in being overweight, obesity and MetS. Improving the lipoprotein profile in these patients may represent an efficient approach for reducing cardiovascular risk.

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The Trp64Arg polymorphism of the β3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study

Cited by 8 publications

References 28 publications

The Correlation Between Small Dense LDL and Reactive Oxygen Metabolites in a Physical Activity Intervention in Hyperlipidemic Subjects

The Correlation Between Small Dense LDL and Reactive Oxygen Metabolites in a Physical Activity Intervention in Hyperlipidemic Subjects

S447X Polymorphism in the Lipoprotein Lipase Gene and the Adiponectin Level in the General Population: Results from the Mima Study

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

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