Small Low-Density Lipoprotein Cholesterol Concentration is a Determinant of Endothelial Dysfunction by Peripheral Artery Tonometry in Men

Okumura, Kenji; Takahashi, Ryōsuke; Taguchi, Noriko; Suzuki, Masayuki; Cheng, Xian Wu; Numaguchi, Yasushi; Ikeda, Nobuo; Murohara, Toyoaki

doi:10.5551/jat.13243

Cited by 8 publications

(7 citation statements)

References 27 publications

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“…Our results showing a negative correlation between heart rate and RHI values is in accordance with some earlier studies [8,22]. Others have found this correlation to be reversed [7].…”

Section: Pat Results and Risk Factorssupporting

confidence: 83%

“…Although several earlier studies have investigated the relation of PAT results to CV risk factors [6][7][8][9], they have provided conflicting results and study populations have varied. Data relating PAT results to comprehensive risk profiles is scarce, particularly with respect to baseline pulse amplitude and augmentation index.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies applying arterial tonometry have revealed a relation between peripheral endothelial dysfunction and coronary endothelial dysfunction as well as severity of CAD [4,5]. Endothelial dysfunction according to PAT has also been connected to several CV risk factors, however with somewhat conflicting results [6][7][8][9]. Limited data is available on the relation between arterial tonometry and global CV risk score.…”

mentioning

confidence: 99%

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Endothelial function assessed by peripheral arterial tonometry is not related to cardiovascular risk score in healthy subjects

Sigurðardóttir

Stefánsdóttir

Aspelund

et al. 2017

ICFJ

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Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide [1]. Although the main risk factors for developing CVD have been known for decades, risk prediction models need to be refined in order to improve their capacity in discriminating true high-risk from low-risk individuals. This is illustrated by the fact that most cases of first myocardial infarction stem from the large group of the population classified as intermediate-or low risk in any modern risk prediction calculator [2]. This knowledge catalyzes a search for novel risk factors to improve CV risk assessment. Measurement of endothelial

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“…Our results showing a negative correlation between heart rate and RHI values is in accordance with some earlier studies [8,22]. Others have found this correlation to be reversed [7].…”

Section: Pat Results and Risk Factorssupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Endothelial function assessed by peripheral arterial tonometry is not related to cardiovascular risk score in healthy subjects

Sigurðardóttir

Stefánsdóttir

Aspelund

et al. 2017

ICFJ

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“…These particles are thought to be less atherogenic than small (LDL-3+) particles, because, compared to smaller LDL particles, they are not able to enter the arterial wall as easily, their binding capacity to proteoglycans is not enhanced, they are less susceptible to oxidation and their affinity to bind to the LDL receptor is not decreased 27 . These features might explain the fact that small LDL particles are related to endothelial dysfunction in several groups of subjects, which is not the case for larger LDL particles 28–30 . However, LDL subclass distribution was not measured in our subjects.…”

Section: Discussionmentioning

confidence: 98%

One-year daily consumption of buttermilk drink containing lutein-enriched egg-yolks does not affect endothelial function in fasting and postprandial state

Made

Berendschot

Kijlstra

2017

Sci Rep

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Previous results have shown that one-year daily consumption of a lutein-enriched egg yolk containing dairy drink did not significantly affect fasting serum lipid and lipoprotein concentrations in adults with early signs of macular degeneration. The current study further substantiates these findings with parameters reflecting endothelial function. Additionally, we extend our observations from the fasting to the postprandial situation. Subjects participated in a 1-y randomized placebo-controlled dietary intervention trial. 52 subjects were included in the active (Egg) group and 49 in the control (Con) group. Changes in postprandial biochemistry (triacylglycerol (TAG), glucose and non-esterified fatty acids (NEFA)) following a mixed meal and flow-mediated dilation (FMD) analyses were evaluated at the start and after one year intervention. Postprandial glycemic and lipemic responses before the intervention as well as the differences in postprandial responses after one-year intervention were comparable between the Egg and the Con group. Fasting FMD was comparable between the groups before the intervention started and at the end of intervention. Additionally, the change in FMD following a mixed meal was comparable between the groups. To conclude, one-year consumption of a lutein-enriched egg yolk incorporated in a dairy drink has no effect on postprandial lipid and glucose metabolism or endothelial function.

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“…59 G Small LDL-C concentration is a determinant of endothelial dysfunction by Peripheral Artery Tonometry in men. 60 . .…”

Section: The Augmentation Indexmentioning

confidence: 97%

Measuring and Evaluating Function, Impairment, and Change with Intervention

Fried¹

2014

Erectile Dysfunction as a Cardiovascular Impairment

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Small Low-Density Lipoprotein Cholesterol Concentration is a Determinant of Endothelial Dysfunction by Peripheral Artery Tonometry in Men

Cited by 8 publications

References 27 publications

Endothelial function assessed by peripheral arterial tonometry is not related to cardiovascular risk score in healthy subjects

Endothelial function assessed by peripheral arterial tonometry is not related to cardiovascular risk score in healthy subjects

One-year daily consumption of buttermilk drink containing lutein-enriched egg-yolks does not affect endothelial function in fasting and postprandial state

Measuring and Evaluating Function, Impairment, and Change with Intervention

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