Loss of Body Weight and Fat and Improved Lipid Profiles in Obese Rats Fed Apple Pomace or Apple Juice Concentrate

Cho, Kyung-Dong; Han, Chan-Kyu; Lee, Bog‐Hieu

doi:10.1089/jmf.2013.2784

Cited by 41 publications

(38 citation statements)

References 40 publications

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“…On the other hand, increased adipose tissue volume can also increase body weight gain. A study by Cho et al (22) reported that the HFD experimental group had the highest level of LDL, total cholesterol and triglyceride, but the lowest levels of HDL. Consumption of HFD causes increased fatty acid synthesis in the liver that results in lipid accumulation that disrupts metabolic homeostasis in the liver.…”

Section: Discussionmentioning

confidence: 98%

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Arifah

Atho'illah

Lukiati

et al. 2020

MJMS

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Introduction: High fat diet (HFD) can cause lipid accumulation and contribute to various metabolic disorders. Single clove garlic oil (SCGO) has advantages over regular garlic due to its higher amounts of organosulfide compounds in particular. This study aimed to determine the ability of SCGO extract to ameliorate hepatic steatosis and improve oxidative status by modulating expression of tumour necrosis factor α and superoxide dismutase in mice fed a HFD.Methods: Twenty-four adult male Balb/C mice were divided into six groups: i) normal diet; ii) positive control diet; iii) negative control diet; and iv) HFD with SCGO at 12.5 mg/kg body weight (mg/kg BW); v) HFD with SCGO at 25 mg/kg BW, vi) HFD with SCGO at 50 mg/kg BW. Liver weight and morphology, spleen weight, serum levels of superoxide dismutase (SOD) and tumour necrosis factor α (TNF-α), TNF-α expression in the aorta and lipid profiles were assessed at the end of the experimental period.Results: SCGO treatment was associated with significant decreases in liver and spleen weight as well as amelioration of hepatic steatosis. SCGO treatment also decreased TNF-α levels and expression. Serum levels of SOD in the SCGO groups were significantly increased compared with the negative control group. Lipid profiles were improved in the SCGO treatment groups compared with the negative control group.Conclusion: SCGO as an herbal medicine could be an effective treatment for degenerative disorders caused by HFD.

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Section: Discussionmentioning

confidence: 98%

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Arifah

Atho'illah

Lukiati

et al. 2020

MJMS

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“…Studies have confirmed this trend in animal models, Cho [12] testing pome apple (PA) and apple juice concentrate (AJC) on different groups with a high fat diet. They found that the groups which were supplied with PA and AJC in the presence of high-fat diet had a lower weight, lower total CHOL, lower CHOL LDL, while CHOL HDL was significantly higher in the PA group compared with AJC.…”

Section: Fo) Fuji Skin (Fp) Traditional Fuji (Tf) Organic Granny Smentioning

confidence: 80%

“…Different apple extracts have been reported to decrease the weight of visceral adipose tissue as compared to controls. Furthermore it has been found that diets supplemented with apple skin have a positive effect on the lipid profile [12] [13]. However, there is insufficient scientific evidence to determine if the source apple extracts such as traditionally or organically managed orchards, as well as green or red fruits and apple skin from by-product of agroindustry or discarded in the orchard have a better result in the lipid profile [14]- [16].…”

Section: Introductionmentioning

confidence: 99%

Apple Extracts Present Catabolic and Hipocolesterolemic Effect in Mice

Poblete¹,

Neira²,

Huilcaman³

et al. 2015

FNS

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Dyslipidemia is highly prevalent in the Chilean population: about 40% have total cholesterol levels over 200 mg/dl and 25% are obese (BMI > 30) which produces an increased risk of cardiovascular disease and deaths. Over consumption of foods rich in lipids and carbohydrates unchains these events, due to the high amount of lipid accumulation in adipocytes. These cells are capable of producing a large number of mediators of inflammation and adipokines which in large quantities can compromise the overall metabolism. Apple has been shown to stop these events. We used CF-1 mice that were fed on a high-fat diet which leads to a metabolic status similar to dyslipidemia. Different types of apple waste were direct from orchard and fruit industry. Extracts obtained were characterized and administered in drinking water. At the end of the 40-day experimental period, biochemical parameters in animals were measured and the weight of white adipose tissue (WAT) was quantified. The results were compared with the normal diet and fat diet controls. All apple extracts decrease total and LDL cholesterol to levels similar to normal control and decrease WAT. Apple extracts may be an effective protector against development of risk factors in cardiovascular disease in the Chilean population.

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“…clorogénico eq./g) y fresas (3,63 mg ác. clorogénico eq./g), que son frutos que se caracterizan por tener un alto contenido fenólico (17) .…”

Section: Discussionunclassified

Efecto de la cáscara o pulpa de Solanum tuberosum sobre el peso de órganos y estrés oxidativo hepático en ratas obesas

Ortiz-Rojas

Bernuy-Osorio

Zea-Mendoza

et al. 2019

Rev Peru Med Exp Salud Publica

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Con el objetivo de determinar el efecto del consumo de harina de cáscara o harina de pulpa de dos variedades de Solanum tuberosum (papa Yungay y papa Canchán) sobre la acumulación de tejido adiposo, peso de órganos y estrés oxidativo en hígado de ratas realizamos un estudio experimental en 24 ratas Holtzman obesas, divididos en cuatro grupos y, sometidas a dietas que contenían 10% de harina de las dos variedades de papa. Los grupos fueron T1: cáscara Yungay, T2: pulpa Yungay; T3: cáscara Canchán; y T4: pulpa Canchán. Al finalizar, se sacrificaron todos los animales para registrar los pesos de órganos y tejido adiposo, y extraer muestras para determinar la actividad enzimática de superóxido dismutasa y catalasa en el hígado. El grupo de ratas obesas que consumió pulpa de variedad Yungay tuvo menor estrés oxidativo en el hígado; además, independientemente de la parte de tubérculo consumido, esta variedad redujo el peso de los riñones.

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Loss of Body Weight and Fat and Improved Lipid Profiles in Obese Rats Fed Apple Pomace or Apple Juice Concentrate

Cited by 41 publications

References 40 publications

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice

Apple Extracts Present Catabolic and Hipocolesterolemic Effect in Mice

Efecto de la cáscara o pulpa de Solanum tuberosum sobre el peso de órganos y estrés oxidativo hepático en ratas obesas

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