Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women

Álvarez, Juan José Criado; Montelongo, Adela; Iglesias, Angel; Lasunción, Miguel A.; Herrera, Emílio

doi:10.1016/s0022-2275(20)37617-3

Cited by 243 publications

(55 citation statements)

References 30 publications

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“…1,15 Although elevated plasma triglycerides are found in all the lipoprotein fractions during late gestation, the triglyceride/cholesterol ratio remains stable in VLDL despite significant changes in both low-density lipoproteins (LDL; 358% change between postpartum and third trimester values) and high-density lipoproteins (HDL; 241% change between postpartum and third trimester values) as gestation advances. 2 During the second and third trimesters, apoprotein (Apo) A-1, ApoB100, lipoprotein(a), and plasma cholesteryl ester transfer protein (CETP) activity increases, while postheparin lipase activities (LPL and hepatic lipase activity) decrease. 2,12 During late gestation, activity of the hormone-sensitive lipase in adipose tissue is enhanced and this in turn augments VLDL production in liver.…”

Section: Lipid Levels In Uncomplicated Pregnanciesmentioning

confidence: 99%

“…The second mechanism to explain the increase in triglycerides in all the circulating lipoproteins during gestation could be impaired removal of lipoprotein triglycerides by 1 or 2 of the lipolytic enzymes, lipoprotein lipase (LPL), or hepatic lipase. 2 During the last third trimester of gestation, activity of hormone-sensitive lipase in adipose tissue is enhanced and this in turn augments VLDL production in liver. In addition, decreased activity of 2 lipolytic enzymes also contributes to this augmentation.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy-induced Hyperlipoproteinemia: Review of the Literature

Başaran¹

2009

Reprod. Sci.

122

103

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It is well known that with the effect of hormonal changes during pregnancy, plasma lipid levels increase. Expected elevations for triglyceride and cholesterol levels during a normal gestational period usually do not exceed 332 mg/dL and 337 mg/dL, respectively (corresponding 95th percentile values). However, elevations over the 95th percentile values can be observed during pregnancy, and patients with levels over these expected adaptation levels can be divided into 2 groups: (1) supraphysiologic hyperlipoproteinemia during pregnancy and (2) extreme hyperlipoproteinemia limited to gestational period (triglyceride level >1000 mg/dL). Regarding the first group, some of these patients may develop hyperlipoproteinemia in their future life. What percentage of these women will translate into hyperlipoproteinemia later in life and how efficiently these women can be screened during pregnancy is an enigma. The underlying disorders in the second group of patients at least include dysbetalipoproteinemia, partial lipoprotein lipase deficiency, and apoprotein E3/3 genotype. Pregnancy had been reported to induce severe hyperlipoproteinemia that is limited to gestational period in these disorders. Dysbetalipoproteinemia, partial lipoprotein lipase deficiency, and apoprotein E3/3 genotype probably bring risks and implications to the future life of the carrying individuals although the true extent of the risks is yet to be defined. When disorders unique to gestational period such as gestational diabetes are considered, pregnancy may be accepted as an opportunity to identify women under risk of cardiovascular morbidity and mortality.

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Section: Lipid Levels In Uncomplicated Pregnanciesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pregnancy-induced Hyperlipoproteinemia: Review of the Literature

Başaran¹

2009

Reprod. Sci.

122

103

View full text Add to dashboard Cite

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“…20 The plasma free fatty acid concentration is abnormally high in pregnancy owing to increased mobilization from adipose tissue. 22 The plasma free fatty acid concentration begins to rise at 20 weeks and eventually reaches a level 4-5 times that in post partum period. Within 2 to 3 days of delivery the plasma FFA concentration falls to normal levels.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of serum lipids and lipoprotein- A levels of women with pregnancy induced hypertension (PIH) and normotensive pregnant women

Fatima¹,

Latha²,

Vani³

et al. 2021

IJCBR

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Hypertensive disorders complicating pregnancy is the one of the most common medical problem of pregnancy. Worldwide, hypertensive disorders in pregnancy causes complication in about 10-16% of pregnancies. High blood pressure in pregnant women is related with incidence of large placental infarct and decreased placental growth resulting in intra uterine fetal growth restriction and intrauterine death. Hypertension in pregnancy is diagnosed when blood pressure is 140/90 mm of hg or greater with proteinuria and edema after 20 week of gestation. Plasma lipid and lipoprotein (a) undergo both qualitative and quantitative changes during pregnancy. During the course of normal pregnancy, plasma triglycerides and cholesterol concentration rises by 200-400% and 25-50% respectively. An abnormal lipid profile is known to be strongly associated with atherosclerotic changes and has direct effect on endothelial dysfunction. In preeclampsia women, thromboxane rise more than in normotensive pregnant women. Increased lipid synthesis causes increase in PGI2:TXA2 ratio and plays a role in pathogenesis of pregnancy induced hypertension (PIH), hence the hyperlipidemia may be an important marker of toxemia of pregnancy. Aim and Objectives: To asses and compare the serum levels of lipid and lipoprotein (a) in pregnant women with PIH and normotensive pregnant women. Materials and Methods: A study conducted on total of 100 pregnant patients (50 cases and 50 controls) selected according to inclusion and exclusion criteria. 3ml of venous blood was drawn to estimate the Serum Cholesterol, Serum Triglycerides, Serum HDL, Serum LDL, Serum VLDL, Serum Lipoprotein (a) levels in each subject. The data was analyzed results were expressed as Mean and standard deviation of various parameters in different group. P value < 0.05 is considered as significant. ROC curve analysis was done to assess maximum sensitivity, specificity and diagnostic efficiency Results: In our study the mean ±SD values of total cholesterol, triglycerides, LDL, VLDL, Serum Lipoprotein (a) are statistically significant higher in PIH cases whereas HDL levels are low in cases when compared to controls. Conclusion: A high lipid profile levels is observed to be associate with preeclampsia thus, serum lipid concentration and serum Lipoprotein (a) levels may provide a useful marker for screening patients at risk for developing PIH.

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“…Furthermore, results showed a significantly positive correlation between serum ANGPTL3 levels with triglyceride, VLDL-c and total cholesterol levels in healthy non-pregnant; however, we did not observe any significant relationship between serum ANGPTL3 and those lipids in healthy and preeclamptic pregnant women, across all trimesters of pregnancy. Maternal accumulation of fat depots occurs in the first two trimesters of pregnancy to supply energy requirements during late pregnancy and lactation, and are attributed to different factors that can act synergistically, including increasing lipogenesis and LPL activity of adipose tissue (12)(13)(14)(15)(16). Furthermore, hormonal related changes during pregnancy, such as the increases of estrogen, progesterone and cortisol levels, favors endogenous de novo lipogenesis and fat deposition in adipose tissue (35).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it has been shown that during the first trimester of pregnancy LPL activity increases in adipose tissue whereas, in the third trimester of pregnancy this activity decreases significantly (12,13). This situation coincides with the transformation from anabolic to catabolic condition and the increase in insulin resistance as pregnancy advances (13)(14)(15)(16). In contrast, LPL expression and activity increase significantly in placental syncytiotrophoblast during the third trimester of pregnancy and correlate with increase of placental capacity to transport lipid for fetal growth (17,18).…”

Section: Introductionmentioning

confidence: 99%

Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women

et al. 2021

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ObjectiveAngiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum.MethodsSerum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices.ResultsLevels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05)ConclusionsWe describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta.

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Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women

Cited by 243 publications

References 30 publications

Pregnancy-induced Hyperlipoproteinemia: Review of the Literature

Pregnancy-induced Hyperlipoproteinemia: Review of the Literature

A comparative study of serum lipids and lipoprotein- A levels of women with pregnancy induced hypertension (PIH) and normotensive pregnant women

Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women

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