A comparative study of serum lipids and lipoprotein- A levels of women with pregnancy induced hypertension (PIH) and normotensive pregnant women

Abstract

Hypertensive disorders complicating pregnancy is the one of the most common medical problem of pregnancy. Worldwide, hypertensive disorders in pregnancy causes complication in about 10-16% of pregnancies. High blood pressure in pregnant women is related with incidence of large placental infarct and decreased placental growth resulting in intra uterine fetal growth restriction and intrauterine death. Hypertension in pregnancy is diagnosed when blood pressure is 140/90 mm of hg or greater with proteinuria and edema after 20 week of gestation. Plasma lipid and lipoprotein (a) undergo both qualitative and quantitative changes during pregnancy. During the course of normal pregnancy, plasma triglycerides and cholesterol concentration rises by 200-400% and 25-50% respectively. An abnormal lipid profile is known to be strongly associated with atherosclerotic changes and has direct effect on endothelial dysfunction. In preeclampsia women, thromboxane rise more than in normotensive pregnant women. Increased lipid synthesis causes increase in PGI2:TXA2 ratio and plays a role in pathogenesis of pregnancy induced hypertension (PIH), hence the hyperlipidemia may be an important marker of toxemia of pregnancy. Aim and Objectives: To asses and compare the serum levels of lipid and lipoprotein (a) in pregnant women with PIH and normotensive pregnant women. Materials and Methods: A study conducted on total of 100 pregnant patients (50 cases and 50 controls) selected according to inclusion and exclusion criteria. 3ml of venous blood was drawn to estimate the Serum Cholesterol, Serum Triglycerides, Serum HDL, Serum LDL, Serum VLDL, Serum Lipoprotein (a) levels in each subject. The data was analyzed results were expressed as Mean and standard deviation of various parameters in different group. P value < 0.05 is considered as significant. ROC curve analysis was done to assess maximum sensitivity, specificity and diagnostic efficiency Results: In our study the mean ±SD values of total cholesterol, triglycerides, LDL, VLDL, Serum Lipoprotein (a) are statistically significant higher in PIH cases whereas HDL levels are low in cases when compared to controls. Conclusion: A high lipid profile levels is observed to be associate with preeclampsia thus, serum lipid concentration and serum Lipoprotein (a) levels may provide a useful marker for screening patients at risk for developing PIH.

Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension

“…Blocking β -receptor can prolong the conduction time of myocardial bioelectric signals in this area, thus reduce the heart rate and myocardial oxygen consumption. It slows down the heart rate and lowers blood pressure at the same time [ 28 ]. The heart rate of patients will not decrease indefinitely after slowing down to a certain extent, and then tend to stabilize by themselves.…”

Interactive Affection of Pre-Pregnancy Overweight or Obesity, Excessive Gestational Weight Gain and Glucose Tolerance Test Characteristics on Adverse Pregnancy Outcomes Among Women With Gestational Diabetes Mellitus

“…The main pregnancy outcomes in this study included: macrosomia, defined as a birth weight of more than 4000g ( 24 ); Large for gestational age (LGA) or small for gestational age(SGA), defined as a birth weight more than 90 th or less than 10 th percentile based on gender and gestational age ( 25 ); Preterm delivery, defined as gestational age at delivery<37 weeks but >28 weeks; Full term low birth weight, defined as a gestational age ≥ 37weeks with birth weight less than 2500g; hypertensive disorders of pregnancy(HDP), defined as blood pressure ≥140/90 mmHg that occurred after 20 weeks gestation but without proteinuria ( 26 ). Other pregnancy outcomes were cesarean section and composite outcome.…”

Gestational weight trajectory and risk of adverse pregnancy outcomes among women with gestational diabetes mellitus: A retrospective cohort study

“…LBW was defined as birthweight less than 2500 g. Preterm birth was considered as infants born before 37 weeks. HDP was defined as blood pressure ≥140/90 mmHg that occurred after 20 weeks gestation but without proteinuria (Fatima et al, 2021 ).…”

“…HDP was defined as blood pressure ≥140/90 mmHg that occurred after 20 weeks gestation but without proteinuria (Fatima et al, 2021).…”