Hypertensive disorders complicating pregnancy is the one of the most common medical problem of pregnancy. Worldwide, hypertensive disorders in pregnancy causes complication in about 10-16% of pregnancies. High blood pressure in pregnant women is related with incidence of large placental infarct and decreased placental growth resulting in intra uterine fetal growth restriction and intrauterine death. Hypertension in pregnancy is diagnosed when blood pressure is 140/90 mm of hg or greater with proteinuria and edema after 20 week of gestation. Plasma lipid and lipoprotein (a) undergo both qualitative and quantitative changes during pregnancy. During the course of normal pregnancy, plasma triglycerides and cholesterol concentration rises by 200-400% and 25-50% respectively. An abnormal lipid profile is known to be strongly associated with atherosclerotic changes and has direct effect on endothelial dysfunction. In preeclampsia women, thromboxane rise more than in normotensive pregnant women. Increased lipid synthesis causes increase in PGI2:TXA2 ratio and plays a role in pathogenesis of pregnancy induced hypertension (PIH), hence the hyperlipidemia may be an important marker of toxemia of pregnancy. Aim and Objectives: To asses and compare the serum levels of lipid and lipoprotein (a) in pregnant women with PIH and normotensive pregnant women. Materials and Methods: A study conducted on total of 100 pregnant patients (50 cases and 50 controls) selected according to inclusion and exclusion criteria. 3ml of venous blood was drawn to estimate the Serum Cholesterol, Serum Triglycerides, Serum HDL, Serum LDL, Serum VLDL, Serum Lipoprotein (a) levels in each subject. The data was analyzed results were expressed as Mean and standard deviation of various parameters in different group. P value < 0.05 is considered as significant. ROC curve analysis was done to assess maximum sensitivity, specificity and diagnostic efficiency Results: In our study the mean ±SD values of total cholesterol, triglycerides, LDL, VLDL, Serum Lipoprotein (a) are statistically significant higher in PIH cases whereas HDL levels are low in cases when compared to controls. Conclusion: A high lipid profile levels is observed to be associate with preeclampsia thus, serum lipid concentration and serum Lipoprotein (a) levels may provide a useful marker for screening patients at risk for developing PIH.
Objective: The purpose of the six months observational study is to evaluate the gynaecological problems of the adolescent girls, attending the gynaecological outpatient department of a secondary care referral healthcare facility in rural south India. Methods: After ethical clearance, adolescent girls in the age group of 10-19 y having gynaecological problems, who had experienced at least 3 consecutive menstrual cycles, and who showed willingness towards study were included; and adolescent girls in 10-19 y age group having a pregnancy and its complications were excluded. Results: Out of 161 adolescent girls, 46.01% belong to late adolescence with more distribution of gynaecological problems. The gynaecological problems majorly observed were menstrual disorder 59.63%, abdominal pain (11.18%), white discharge per vagina (9.94%), and 8.07% of heavy menstrual bleeding. The menstrual disorder complained with amenorrhea 40.63%, polymenorrhea 18.75%, and menorrhagia 16.67%. In our study, 26.09% and 32.3% of adolescent girls were anaemic and underweight, respectively. Conclusion: In conclusion, our study showcased evidently that young adolescent girls are at higher risk of both gynaecological problems and menses disorders in the rural setting; for whom more amount of awareness to be parented and education of menstrual hygiene and hemodynamic effects has to be culminated through health education, for a future healthier nation.
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