Longitudinal Associations Between Blood Lead Concentrations Lower Than 10 μg/dL and Neurobehavioral Development in Environmentally Exposed Children in Mexico City

Téllez‐Rojo, Martha María; Bellinger, David C.; Arroyo-Quiroz, Carmen; Lamadrid‐Figueroa, Héctor; Mercado‐García, Adriana; Schnaas-Arrieta, Lourdes; Wright, Robert O.; Hernández-Ávila, Mauricio; Hu, Howard

doi:10.1542/peds.2005-3123

Cited by 217 publications

(125 citation statements)

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“…When considering memory, we also have to consider a cognitive function tightly related to language, negatively affected by the lead intoxication, as well as other cognitive functions, even when it is below 10 g/dl (3,8,9). The findings of the present study agree with the ones mentioned above, once it was found a considerable amount of damage in this function.…”

Section: Discussionsupporting

confidence: 90%

“…Some authors suggest that even lower lead levels than the accepted by the World Health Organization present risk for disorders in the skills mentioned above, indicating that a security margin does not exist for lead exposure (3,(7)(8)(9). On the other hand, certain studies do not find correlation between the blood lead level and the neuropsychological dysfunctions presented by contaminated children, evidencing that genetic and environmental factors may aggravate the hindering effects of the lead in the neural development, making some children more vulnerable to the neurotoxic effects of the metal, or yet, despite having a significant influence in children's development, other environmental factors may be even stronger (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

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Caracterização das alterações de linguagem em crianças com histórico de intoxicação por chumbo

Gahyva

Crenitte

Caldana

et al. 2008

Pró-Fono R. Atual. Cient.

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Background: lead poisoning can have a negative impact on the neuropsychological functions, including language, due to the damage it causes to the development of the Central Nervous System. Aim: to verify the occurrence of language disorders in children who suffered from led poisoning and to verify the correlation between the lead concentration level in the blood and the language disorders presented by the children. Method: language evaluation of 20 preschoolers, with lead concentration level in the blood above 10µg/dl. Results: 13 children presented language impairment involving only phonology or more than one language subsystem. The statistical analysis indicated that no correlation exists between the severity of the language impairment and the concentration levels of lead. Conclusion: the number of children with language impairment indicates lead poisoning as a risk factor for the present alterations, even though other risk factors for language disorders were found and the absence of correlation between the investigated variables.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Caracterização das alterações de linguagem em crianças com histórico de intoxicação por chumbo

Gahyva

Crenitte

Caldana

et al. 2008

Pró-Fono R. Atual. Cient.

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“…2 Historical and recent research show that there is no safe exposure to lead in children without doing permanent and irreparable neurological, neurobehavioral, and physiological damage. [2][3][4][5][6][7][8][9][10][11][12][13] This damage may include a wide range of problems in children with the most common effect being permanent behavioral and learning deficits such as reduced IQ, ADHD, memory loss, etc. 2 Evidence of this irreparable damage led the Centers for Disease Control and Prevention (CDC) to lower the reference level (previously called the level of concern) for lead poisoning from ≥10 to ≥5 μg/dL in 2012.…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Neighborhood Socioeconomic Differences and Racial Residential Segregation to Childhood Blood Lead Levels in Metropolitan Detroit

2016

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This study uses a new approach to assess the impact of different neighborhood characteristics on blood lead levels (BLLs) of black versus white children in metropolitan Detroit. Data were obtained from the Michigan Department of Community Health and the US Bureau of the Census American Community Survey. The Modified Darden-Kamel Composite Socioeconomic Index, bivariate regression, and the index of dissimilarity were used to compute neighborhood BLL unevenness by neighborhood characteristics. Neighborhoods with lower socioeconomic characteristics and high racial residential segregation predicted higher average childhood BLLs. This reveals a social spatial structure that will aid researchers/policymakers in better understanding disparities in childhood BLLs.

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“…Se indica que todos los niños que viven en zonas reconocidas como de riesgo alto de intoxicación tengan pruebas de sangre y que sus niveles se mantengan bajo 10 µg/dL, porque varios estudios han demostrado alteraciones neurológicas y de conducta, aún a niveles más bajos que 10 µg/dL (9)(10)(11)(12) . En lugares de trabajo, el límite permisible promedio de plomo es 50 µg/m3 por la jornada de 8 horas (OSHA, Occupational Safety Health Administration, Department of Labor, Washington, DC).…”

Section: Absorción Del Plomounclassified

Intoxicación por plomo en humanos

Poma

2013

An Fac med

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ResumenEl plomo es un metal que se ha usado extensamente desde la antigüedad, por lo que se le puede demostrar en la mayoría de personas. Este metal afecta sistemas, órganos y tejidos y su efecto puede ser proporcional a la cantidad presente en el organismo. Pero los umbrales de sus efectos tóxicos varían en diferentes individuos. Los niños generalmente absorben una mayor proporción del plomo y con un efecto más severo que los adultos, porque están en un proceso activo de desarrollo y por ciertas características fisiológicas, patológicas y de conducta. Los servicios de salud pública pueden identificar áreas en que la población tiene un riesgo mayor de intoxicación con plomo y establecer condiciones para el despistaje, identificación temprana y tratamiento de las personas afectadas. La determinación de plomo en sangre venosa es la prueba más sensible de exposición al plomo. Se recomienda que los niveles en sangre se mantengan debajo de 10 µg/dL. Este artículo revisa las fuentes de contaminación, efectos, diagnóstico y tratamiento del plomo. Palabras clave: Intoxicación por plomo; prevención, toxicidad, diagnóstico. AbstractLead, a metal that has been extensively used since antiquity, can be found in the majority of persons. This metal affects systems, organs, and tissues. The thresholds for its toxic effects vary from individual to individual. Probably because they are in the process of development and due to cer tain physiological, pathological y behavioral characteristics children usually absorb a greater proportion of lead with more severe outcomes than adults. Public health services can identify areas where people has a higher risk for lead intoxication and establish requirements for screening, early diagnosis and adequate treatment. The determination of lead in venous blood is the most sensitive test for the evaluation of lead exposure. Experts recommend maintaining a level below 10 µg/dL. This article reviews origin, effects, diagnosis and treatment of lead intoxication.Key words: Lead poisoning; prevention, toxicity, diagnosis.El plomo es un metal blando, gris azulado, estable y resistente a la corrosión. Sin embargo, cuando forma parte de tuberías, conexiones o soldaduras, en presencia de agua ligeramente ácida puede contaminar el agua potable (1) . El plomo no conduce bien la electricidad, posee una temperatura de fusión baja, por lo que se le utiliza (fusible) en algunas partes de las instalaciones eléctricas; cuando la carga eléctrica excede un nivel predeterminado, se funde e interrumpe la transmisión eléctrica. Este metal también ofrece protección contra la radiación, por lo que se emplea en mandiles de trabajadores de salud y en las paredes de los salones de diagnóstico y tratamiento radiológico. Desde la antigüedad, el plomo ha sido usado extensamente y se le puede encontrar en casi todas las personas, aún a niveles elevados (2) . Este metal existe en forma inorgánica y orgánica. La forma inorgánica puede encontrarse en las pinturas, tierra, polvo y en otros productos de manufactura. Los gases de l...

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Longitudinal Associations Between Blood Lead Concentrations Lower Than 10 μg/dL and Neurobehavioral Development in Environmentally Exposed Children in Mexico City

Abstract: These analyses indicate that children's neurodevelopment is inversely related to their blood lead levels even in the range of < 10 microg/dL. Our findings were consistent with a supralinear relationship between blood lead levels and neurobehavioral outcomes.

Cited by 217 publications

References 17 publications

Caracterização das alterações de linguagem em crianças com histórico de intoxicação por chumbo

Caracterização das alterações de linguagem em crianças com histórico de intoxicação por chumbo

The Relationship of Neighborhood Socioeconomic Differences and Racial Residential Segregation to Childhood Blood Lead Levels in Metropolitan Detroit

Intoxicación por plomo en humanos

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