“…Traditional clinical treatments for maxillofacial tumours include surgery, radiotherapy, and chemotherapy. Unfortunately, current clinical therapies are destructive to hosts, resulting in unsatisfactory therapeutic outcomes as follows: (1) Physiological dysfunction [10][11][12] , including issues with chewing, speech, swallowing, sucking, and breathing, owing to the lack of maxillofacial bone and radiation and chemotherapeutic drug damage; (2) Psychological damage resulting from the impairment of normal physiological functions and maxillofacial deformity 13,14 , which could lead to depression and misanthropy in patients; and (3) Frequent tumour recurrence due to cancer cells that survive surgery, inaccessibility of tumours during operations, unpredictable variation and constantly increasing drug resistance. Some novel methods, such as immunotherapy 15,16 , have shown strong potential, particularly biomaterial-mediated therapies (including targeted chemotherapy, magnetic-mediated hyperthermia (MMT), photodynamic therapy (PDT), and photothermal therapy (PTT)), which have demonstrated high anticancer efficiency, specific tumour targeting properties, excellent biocompatibility and low invasiveness.…”