Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

Abstract

Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable tumour recurrence, and metastasis are major threats to the patients’ lives in the clinic. Fortunately, biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis, suggesting new promising antitumour therapies. In addition, maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients, and investment in treatment can result in a multitude of burdens to society. Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration. More interestingly, an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option. Herein, we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair. Furthermore, we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold

“…Oral-maxillofacial bone tissue not only maintains the maxillofacial structure and appearance but also supports the functions of the oral maxillofacial system [ 1 ]. Critical oral-maxillofacial bone defects, such as damage by trauma and tumors, affect the physiological functions and mental health of patients [ 2 ].…”

“…Growing developments in synthetic biomaterials show promise for replacing autografts in oral-maxillofacial bone tissue reconstruction applications [ 1 , 4 , 5 ]. With the evolution of personalized medicine, synthetic biomaterials have been increasingly used in the reconstruction of oral-maxillofacial bone defects through the advanced applications of cone-beam computed tomography combined with three-dimensional (3D) printing technology [ 6 , 7 ].…”

Craniofacial Bone Tissue Engineering: Current Approaches and Potential Therapy

“…In the last decades, the number of surgeries involving allogeneic grafting tissue increased more than 15 times [ 147 , 166 , 168 , 175 ]. The main advantages of bone allografts are to provide structural support [ 32 , 166 , 176 ], decrease surgical time [ 32 , 149 , 176 ], and promote cranial healing [ 149 , 175 , 176 ]. The three most common bone allograft types are cortical, cancellous, and hybrid bone tissue (cortical and cancellous bone tissue) [ 23 , 157 , 171 ].…”

“…An alloplastic bone substitute is a biocompatible material that is produced synthetically by physical or chemical processing. In recent years, alloplastic bone substitutes have gained more attention, mainly in craniofacial bone reconstruction [ 170 , 176 ]. While surgical procedure to repair cranial defects is known as cranioplasty [ 35 , 40 , 177 ], the term of alloplastic bone substitute is associated with synthetic biomaterials [ 160 , 166 ].…”

Jawbones Scaffold Constructed by TGF-β1 and BMP-2 Loaded Chitosan Microsphere Combining with Alg/HA/ICol for Osteogenic-Induced Differentiation

“…Bone tissue defects caused by maxillofacial tumor, trauma, and disease along with various other factors are a common problem in orthopedics [6], which are usually solved by autologous bone graft, allograft, and xenograft [7]. However, the source of autogenous bone is limited, and there is immune rejection of allogeneic and heterogeneous bones.…”