Long-term Follow up Study of Vertical HTLV-I Infection in Children Breast-fed by Seropositive Mothers

Ando, Yumiko; Matsumoto, Yoshinari; Nakano, Shiro; Saito, Kensuke; Kakimoto, Kazuhiro; Tanigawa, Takuo; Ekuni, Yutaka; Kawa, Motohiro; Toyama, Takenori

doi:10.1053/jinf.2002.1107

Cited by 28 publications

(25 citation statements)

References 8 publications

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“…[18][19][20] Therefore, based on this evidence, we recommend that prophylactic measurements regarding HTLV-1 infection transmission from mother to child should also be adopted in Brazil. In this matter, we are facing a dilemma.…”

Section: Discussionmentioning

confidence: 99%

Prevalence Ratio of HTLV-1 in Nursing Mothers From the State of Paraíba, Northeastern Brazil

Pimenta

Kashima²,

Filho

et al. 2008

J Hum Lact

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The human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus known as a direct causal agent of a malignant disease. The vertical route of HTLV transmission is the most frequent pathway of the virus contamination. This study was performed to determine the prevalence ratio of HTLV-1 infection among nursing women. From January 2004 to January 2005, blood samples from 1033 nursing mothers from Paraíba, Brazil were evaluated for HTLV antibodies by ELISA and HTLV-1 viral particles confirmed by polymerase chain reaction (PCR). HTLV antibodies were detected in 7 women. The overall seroprevalence ratio was 0.68% and HTLV-1 viral sequences were confirmed by PCR in 2 women. These preliminary data suggest that HTLV screening should be introduced as a mandatory test before breastfeeding and breast milk donation in Paraíba, Brazil. Additionally, counseling programs would help reduce the prevalence ratio of HTLV-1 infected individuals in this Brazilian region.

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Section: Discussionmentioning

confidence: 99%

Prevalence Ratio of HTLV-1 in Nursing Mothers From the State of Paraíba, Northeastern Brazil

Pimenta

Kashima²,

Filho

et al. 2008

J Hum Lact

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“…Studies have reported HTLV infection in mother's milk-fed infants several years after birth 34 , depending on the duration of feeding 35,36 . It is usually considered as a risk factor for HTLV infection with an exposure period higher than 6 months, which denominates the long-term breast-feeder.…”

Section: Rev Soc Bras Med Trop 45(4):453-456 Jul-aug 2012mentioning

confidence: 99%

Descriptive study of HTLV infection in a population of pregnant women from the state of Pará, Northern Brazil

Sequeira

Tamegão-Lopes

Santos

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction:In Brazil, studies have shown that HTLV seroprevalence among pregnant women varies from 0 to 1.8%. However, this seroprevalence was unknown in the State of Pará, Brazil. The present study describes, for the first time, the HTLV seroprevalence among pregnant women from the State of Pará, Northern Brazil. Methods: 13,382 pregnant women were submitted to HTLV screening during prenatal care, and those with non-seronegative results to anti-HTLV were submitted to Western blot (WB) test to confirm and separate HTLV-1 and HTLV-2 carriers. Results: HTLV seroprevalence in the population of pregnant women was 0.3%, and HTLV-1 was identified in 95.3% of patients. The demographic profile of HTLV carriers was as follows: women with age between 20 and 40 years old (78.4%); residing in the metropolitan region of Belém, Pará (67.6%); and with educational level of high school (56.8%). Other variables related to infection were as follows: beginning of sexual intercourse between the age of 12 and 18 years old (64.9%) and have being breastfed for more than 6 months (51.4%). Most of the women studied had at least two previous pregnancies (35.1%) and no abortion (70.3%). Coinfections (syphilis and HIV) were found in 10.8% (4/37) of these pregnant women. Conclusions: Seroprevalence of HTLV infection in pregnant women assisted in basic health units from the State of Pará, Northern Brazil, was 0.3% similar to those described in other Brazilian studies. The variables related to infection were important indicators in identifying pregnant women with a higher tendency to HTLV seropositivity, being a strategy for disease control and prevention, avoiding vertical transmission.

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“…8 Breastfeeding is proscribed when separation of mother and infant is indicated because of risk for aerosolized transmission of bacteria. 12 Patient has a documented, recent TST conversion but has not been completely evaluated. 9 Consult with TB specialist about MDR TB.…”

Section: Arenavirusesmentioning

confidence: 99%

Transmission of Infectious Diseases Through Breast Milk and Breastfeeding

Lawrence¹

2011

Breastfeeding

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Long-term Follow up Study of Vertical HTLV-I Infection in Children Breast-fed by Seropositive Mothers

Cited by 28 publications

References 8 publications

Prevalence Ratio of HTLV-1 in Nursing Mothers From the State of Paraíba, Northeastern Brazil

Prevalence Ratio of HTLV-1 in Nursing Mothers From the State of Paraíba, Northeastern Brazil

Descriptive study of HTLV infection in a population of pregnant women from the state of Pará, Northern Brazil

Transmission of Infectious Diseases Through Breast Milk and Breastfeeding

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