Prevalence Ratio of HTLV-1 in Nursing Mothers From the State of Paraíba, Northeastern Brazil

Pimenta, Flávia Cristina Fernandes; Kashima, Simone; Filho, João Ghizzo; Costa, Maria J.; Diniz, Margareth F. M.; Fernandes, Melina P; Araújo, Lenisio B de; Pombo‐de‐Oliveira, Maria S.

doi:10.1177/0890334408316084

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…The HTLV-I provirus was detected by PCR in both peripheral blood and breast milk from all the seropositive cases tested, except one that tested positive for HTLV-I antibody but did not have provirus detected by PCR analyses. This case could be explained as newly infected woman with low viral load as previously reported (Kaplan et al 1996, Pimenta et al 2008).…”

Section: Discussionsupporting

confidence: 69%

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Human T Lymphotropic Virus Type I Infection in Pregnant Women in Rio De Janeiro, Brazil

Câmara¹,

Simonetti²,

Simonetti³

et al. 2010

VR&R

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Human T lymphotropic virus type I (HTLV-I) is a retrovirus and the transmission occurs from mother to child, by sexual contact or by blood transfusion. This study was performed to evaluate the prevalence ratio of HTLV infection in a group of 389 pregnant women attending at Fernandes Figueira Institute, Fiocruz, in Rio de Janeiro, Brazil. The specimens were screened for HTLV antibodies by ELISA and reactive samples were submitted to a Western Blot (WB) for confirmation. Detection of HTLV-I provirus in DNA from peripheral blood mononuclear cells (PBMC) and breast milk mononuclear cells (BMMC) from the seropositive women, was performed by PCR using primers for LTR, tax, pol regions. Of the 389 pregnant women tested, four (1%) were HTLV-I seropositive and three were indeterminate in the WB. PCR was done in three of the seropositive cases and HTLV-I provirus was detected in PBMC and BMMC from two of them. Three blood samples (0.8%) that presented WB indeterminate patterns, were negative by PCR. Our data indicate that the frequency of HTLV-I infection among pregnant women is relatively high in Rio de Janeiro and that preventive measures against the vertical transmission of the virus must be adopted in Brazil.

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Section: Discussionsupporting

confidence: 69%

“…Salvador, where the HTLV-I prevalence rate was 0.84% (Bittencourt et al 2001) and Paraíba, where the rate was 0.68% (Pimenta et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Human T Lymphotropic Virus Type I Infection in Pregnant Women in Rio De Janeiro, Brazil

Câmara¹,

Simonetti²,

Simonetti³

et al. 2010

VR&R

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“…In the case of milk banks, we recommend testing for HTLV-1 before the donation even if the milk is subjected to viral inactivation procedures, such as pasteurization [17].…”

Section: Discussionmentioning

confidence: 99%

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

Ms¹,

Cf²,

G³

et al. 2014

Trop Med Surg

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Objective: Although HTLV-1 is associated with severe diseases, there is ongoing vertical transmission since prenatal HTLV screening is not implemented in countries where the virus is present. We performed a cross-sectional analysis to verify the impact of counseling pregnant HTLV-1 seropositive women, who participate in the GIPH cohort study in Brazil, on this vertical transmission.Methods: GIPH study started in 1997 as an open prevalent cohort of HTLV-positive individuals. Children born from HTLV-1 seropositive women were divided into: (1) born before and (2) after the participation of mothers in the GIPH cohort ("GIPH babies"). The pregnant women participating in the study were counseled in order to prevent viral transmission, with recommendations of avoiding breastfeeding, giving infant formula, and preferably having the delivery by cesarean section. Results:We identified 54 children born of HTLV seropositive mothers. 3/21 (14.3%) of the children born from mothers who received no counseling were found positive for HTLV-1, in contrast to 1/18 (5.6%) of the "GIPH babies", whose mothers received counseling. 15 children were not tested, either due to the family's refusal or impossibility to locate them. Discussion:We found that it was worthwhile to counsel the mothers, since, as previously reported in the literature, we could observe a decline in the vertical transmission, which demonstrates the importance of prenatal screening of the virus. These actions should be widespread in countries where HTLV is present, in order to avoid the silent transmission of HTLV and future diseases in children born from positive mothers.

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“…As a consequence of the transmission routes, all blood donated at the Red Cross Blood Centers in Japan has been subjected to HTLV-1 antibody screening since November 1986 and carrier mothers have been instructed to refrain from breastfeeding to prevent HTLV-1 transmission (9-11) . In the United States, screening began at the end of 1988 and in the entire world since 1990 (12-15) .…”

mentioning

confidence: 99%

Human T lymphotropic virus types 1 and 2: a point of view

Luzo

2013

Revista Brasileira De Hematologia E Hemoterapia

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Prevalence Ratio of HTLV-1 in Nursing Mothers From the State of Paraíba, Northeastern Brazil

Cited by 9 publications

References 20 publications

Human T Lymphotropic Virus Type I Infection in Pregnant Women in Rio De Janeiro, Brazil

Human T Lymphotropic Virus Type I Infection in Pregnant Women in Rio De Janeiro, Brazil

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

Human T lymphotropic virus types 1 and 2: a point of view

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